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The goal § Accessible (and inclusive) availability of the three runic inscriptions and their metadata according to the FAIR principles 1. The state of the art § Damaged writing support § Progressive difficulty in reading the inscriptions § No ontological description of the texts and of the metadata available to date 3. The Method § Texts: TEI- EpiDoc XML (v. 9.5) and CRMtex (2.0 model) § Metadata: CRMtex (2.0 model) 4. Example: the inscription on the right shoulder vRunic texts: TEI-EpiDoc XML (v. 9.5) vMetadata: CRMtex (2.0 model) 5. Next Steps ØRTI-Dome ØLemmatization ØLinking ontological description to the 3D model Runes in Venice. Ontological description of the runic inscriptions on the Piraeus Lion (Venetian Arsenal) Paola Peratello Università Ca’ Foscari Venezia paola.peratello@unive.it DH Benelux 2024, Leuven: Breaking Silos, Connecting Data: Advancing Integration and Collaboration in Digital Humanities <div type="textpart" subtype="fragment" n="1"> <ab> <lb n="1"/>ᛅ<unclear>ᛍᛘ</unclear>ᚢᚾ<unclear>ᛐ</unclear>ᚱ᛭ᚱᛁ<unclear>ᛍᛐ</unclear>ᛁ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap><unclear>ᚾ</unclear>ᚱᚦᛁᛍᛅᚱ᛭ᚦᛅᛁᚱ᛭ᛁᛍ<unclear>ᚴ</unclear> <lb n="2"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚦ<unclear>ᚢ</unclear>ᚱᛚᛁᚠ<unclear>ᚱ</unclear><gap reason="lost" quantity="4" unit="char"></gap>ᛅᚢᚴ᛭<gap reason="lost" quantity="1" unit="char"></gap>ᚢ/ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="1" unit="char"></gap>ᚬ<gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="5" unit="char"></gap><unclear>ᛐ</unclear><gap reason="lost" quantity="1" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage> <lb n="3"/><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᚠᚱᚢ<unclear>ᚴ</unclear><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚱ<damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><unclear>ᛋ</unclear><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage><gap reason="lost" quantity="2" unit="char"></gap><damage><gap reason="lost" extent="unknown" unit="char"></gap></damage>ᚢᛅᚾᚠ<unclear>ᛅᚱᚾ</unclear>᛭ </ab> </div> TEI/EpiDoc XML Photos by Paola Peratello, 2023, on concession of the Comune di Venezia and of the Arsenale di Venezia. 1. Nᛍᛘunᛐᚱ᛭ᚱᛁᛍᛐᛁ…-nᚱᚦᛁᛍNᚱ᛭ᚦNᛁᚱ᛭ᛁᛍᚴ 2. …ᚦuᚱᛚᛁᚠᚱ----Nuᚴ᛭-u/ᚱ…-ᚬ-…-----ᛐ-… 3. …uᚠᚱuᚴ…ᚱ…ᛋ--…--…uNnᚠNᚱn᛭ Check the bibliography here Transrunification from Snædal 2016 Ontological description according to CIDOC-CRM and CRMtext Check the project here	poster
Figure 8. Crystal structure of both a type II inhibitor, ima7nib, and a type IV inhbitor, GNF-‐2, bound to the kinase domain of c-‐ Abl (3K5V.pdb). GNF-‐2 is a fully allosteric inhibitor of WT Abl and rescues type I/II inhibitor eﬃcacy against T315I both in vitro and in vivo. Gly250 Tyr253 Glu255 Met351 Phe359 Thr315 In addi7on to playing an essen7al role in cellular energe7cs, kinases and their associated signaling pathways regulate a plethora of intracellular processes. When aberrantly expressed or controlled, kinases can cause cellular dysregula7on and contribute to the onset of several diseases, including cancer. Based on the fundamental understanding of kinase dysregula7on in cancer biology, the discovery of small organic molecules to alter kinase func7on has culminated in the development of targeted cancer therapy. However, limited selec7vity and the emergence of drug resistance remain fundamental challenges for current modern medicinal chemistry eﬀorts aimed at the development of kinase inhibitors that are both safe and eﬀec7ve as long-‐term treatments. Muta7ons resistant to classical ATP-‐compe77ve (Type I/II) kinase inhibitors emerged at a rapid pace and oTen limit the success of newly available targeted cancer therapies. At present, there are more than 70 individual muta7ons at more than 50 muta7on sites conferring diﬀerent levels of ima7nib resistance found within CML pa7ents. Recently, a number of Type IV kinase inhibitors that func7on via a fully allosteric mechanism of ac7on have demonstrated promise toward addressing muta7on dependent drug resistance. BINDING STUDIES OF TYPE I, II, AND IV KINASE INHIBITORS AGAINST ABL KINASE USING BACK-‐SCATTERING INTERFEROMETRY MOA FOR ALLOSTERIC INHIBITORS THAT OVERCOME DRUG RESISTANCE Fei Shen, Nathaniel Gilbert, Robert R. Lavieri, Richard J. Isaacs, Scot R. Weinberger Molecular Sensing, Inc. Back-‐scaNering Interferometry The Back-‐scaYering device is a micro-‐scale interferometer (see ﬁgure 4). The BSI device consists of a HeNe laser, a microchip, and a CCD camera. The microchip receives light from the laser and illuminates the sample containing channel. As light passes into the channel, interference fringe paYerns arise and a camera images the fringes (Figure 4). When molecules bind, the resultant complex causes a change in molecular mean polarizability that is measured as a fringe paYern shiT. Monitoring the change in fringe phase as a func7on of ligand concentra7on allows equilibrium dissocia7on constant (Kd) measurements to be performed. SeRng up the BSI assay BSI Kd determina7ons are performed in end-‐point fashion, with target and ligand pre-‐incubated to establish equilibrium. Target and ligand concentra7ons are chosen to ini7ate pseudo-‐ﬁrst order binding condi7ons, for which the target is typically held at a sparing concentra7on and the ligand is present in excess to avoid ligand deple7on during the binding process. Back-‐scaNering Interferometry Kinase inhibitor binding analysis and BSI data validaTon References Materials and Methods www.molsense.com Sample Reference Figure 11. Prepara7on of kinase Inhibitors. Ima7nib, dasa7nib, nilo7nib and GNF-‐5 were prepared as 50 mM working stocks in 100% DMSO. Dose response series were created by dilu7ng each working stock with MOPS buﬀer to establish the appropriate target concentra7on range for each binding system using a 12-‐point doubling dilu7on (range: 50 pM – 125 μM). DasaTnib (nM) NiloTnib (nM) ImaTnib (nM) c-‐Abl Kinase IC50 KD IC50 KD IC50 KD Wild-‐type 1.83 1.08 17.69 13.3 527 472 M351T 1.61 0.42 7.8 2.7 926 1086 Q252H 5.6 5.49 46.7 47.6 733 961 H396P 1.95 0.7 42.6 32.6 1280 1228 T315I 137 86.5 696 761 9221 4050 Figure 9. 9A. The Kd of ATP for both WT and T315I Abl is about 4-‐5 micromolar. 9B. The Kd values for GNF-‐5 vs. WT and T315I Abl are about 510 nM and 130 nM respec7vely. 9C. Interes7ngly, in the presence of a satura7ng amount of GNF-‐5 (50 μM) the binding curve for ATP is right-‐shiTe	poster
SUBUrB Software zur Unterstützung von Bibliotheken bei urheberrechtlichen Bewertungen • Problem: Bestandslücken bei Bibliotheken • Fehlende Bücher müssen beschafft werden • Prüfung des Urheberrechts • Gemeinfreie Bücher können ausgeliehen und kopiert werden • Geschützte Bücher müssen (wenn verfügbar) gekauft werden • Prüfungen sehr aufwendig • Bisher manuell erledigt Literatursoftware SUBUrB • Prüfungen lassen sich automatisieren • Urheberrecht folgt klaren Regeln • Autoren seit über 70 Jahren tot: Werk gemeinfrei • Sonst: Werk geschützt • Software recherchiert Todesdaten • Beurteilung je nach Informationsstand Idee • Nutzer können Bücherlisten anlegen • Software sucht nach Daten in Katalogen • Deutsche Nationalbibliothek • Landesbibliotheken • … • Ergänzung fehlender Daten • Urheberrechtliche Beurteilung wird erstellt • Triviale Fälle können auch bei fehlenden Daten abgehandelt werden • Buch älter als 180 Jahre • Buch jünger als 70 Jahre • Ergebnisse werden übersichtlich dargestellt Funktionsumfang • Implementierung eines Prototypen • Vorstellung der Idee+Prototyp auf dem IRIS 2015 • 2. Platz beim Best Paper Award Aktueller Stand • Kooperation mit der Europäischen EDV-Akademie des Rechts (EEAR) • Suche nach Partnern (Bibliotheken) • Anpassung an Bedürfnisse der (späteren) Kunden • Erweiterungen für Digitalisierungsprojekte • Verwaiste und vergriffene Werke Entwicklung juris-Stiftungsprofessur für Rechtsinformatik Prof. Dr.-Ing. Christoph Sorge Cand. iur. Stefan Hessel Frederik Möllers, M.Sc. Übersicht über verwaltete Bücher (Screenshot des Prototypen). Verwaltung einzelner Werke (Screenshot des Prototypen). Dieses Werk ist lizenziert unter einer Creative Commons Namensnennung 4.0 International Lizenz.	poster
Draft Simulation studies for the ATLAS track-counting luminosity measurement Giulia Ripellino on behalf of the ATLAS Collaboration Abstract A precise measurement of the luminosity is a key component of the ATLAS physics programme. ATLAS uses several detectors and algorithms to determine the luminosity. The absolute calibration of these algorithms is carried out in LHC runs with special beam conditions at low luminosity. The track-counting luminosity measurement is used to determine the calibration transfer from the low-luminosity regime to the high-luminosity conditions typical of standard physics data taking, and to monitor the long term stability of the default luminosity method. The track-counting method works by counting the number of reconstructed tracks from charged particles inside the Inner Detector. The average number of charged particles in randomly-triggered events is proportional to the average number of inelastic collisions per event and can therefore be used to compute the luminosity. This poster presents simulation studies for the ATLAS track-counting luminosity measurement. A toy simulation model is used to study the underlying distribution of the number of tracks and to illustrate the linearity between the average number of tracks and the luminosity. Full ATLAS MC simulation is used to assess effects related to the reconstruction of the tracks and their effect on the linearity. Method The LHC bunch luminosity is given by Lb = µfr σinel (1) where µ is the average number of inelastic pp collisions per event, fr the LHC revolution fre- quency, and σinel the pp inelastic cross-section. • The track-counting measurement uses the av- erage number of charged tracks of randomly triggered events to measure the luminosity. • The visible interaction rate is given by µvis = ⟨Ntracks⟩= Nevents P i=1 N i tracks Nevents ∝µ. (2) • Two different track selections are explored Selection \|η\| N Pixel Holes \|d0/σd0\| pT 2016 < 2.5 0 < 7 > 0.9 GeV 2017 < 1.0 ≤1 Track selections for the track-counting measurement, based on the TightPrimary selection defined in Ref. [1]. Track-multiplicity pdf in MC Normalized track distributions in a Pythia8 A3 minimum bias MC sample with exactly one pp interaction per event. The distributions can be interpreted as the track-multiplicity probability density functions (pdfs) for each track selection. Linearity in toy simulation The linearity between µvis and µ illus- trated in a toy simulation model. For each event, the number of interactions is determined from a Poisson distribution with mean µ. The number of tracks per interaction is then sam- pled from the track-multiplicity pdf. The result- ing track distribution is used to determine the mean number of tracks per event for the spe- cific value of µ. The proportionality constant between µvis and µ corresponds to the mean of the track-multiplicity pdf. Linearity in full simulation Relation between µvis and µ in full simula- tion. A Z →µµ MC sample with overlaid mini- mum bias events as pileup is used for the study. Tracks from the hard scatter interaction are ex- cluded in the number of reconstructed tracks. The µ-dependence is parameterised by a first- order polynomial, fitted in the range µ<40. The non-linearity results from the effects of track reconstruction efficiency and fake tracks. The higher non-linearity in the 2017 selection is likely due to the looser track-selection requirements. Track-multiplicity pdf in data The 2017 track selection MC pdf is compared to data in order to assess the modelling of the track multiplicity. The data track-multiplicity pdf is derived from the distribution of the number of tracks per event in data with ⟨µ⟩≪1 (left), selected for the purpose of eliminating events with more than one pp interaction. Events with zero tracks can arise either from bunch crossings where no pp interaction occurred (“empty crossings”), or from bunch crossings with one pp interaction in which no track satisfied the track-selection criter	poster
NF Research Tools Database: An experimental resource database for the neurofibromatosis community 1 Sage Bionetworks , Seattle, WA, USA 2 Gilbert Family Foundation, Detroit, MI, USA Correspondence: nf-osi@sagebionetworks.org Brynn Zalmanek, MLIS1, Robert Allaway, PhD1, James Goss, PhD2, Ashley Clayton, MS1, James Eddy, PhD1, Kaitlin Throgmorton, MLIS1, Jineta Banerjee, PhD1, Kalyan Vinnakota, PhD2, Caroline Morin, BS2, YooRi Kim, MS2, Justin Guinney, PhD1 Approach Highlights ●We are developing a centralized resource database for NF1 research tools, including animal models, cell lines, antibodies, genetic reagents, and biobanks. ●The research community will be able to contribute feedback, usage notes, and other observations about these tools to the database. ●We are recruiting testers to participate in an upcoming evaluative design study to ensure that this resource is useful for the research community. Background & Introduction ●When the Gilbert Family Foundation (GFF) started to fund investigators with little or no prior experience in NF1 research, it became evident that research progress was impacted by the challenge of identifying, evaluating, obtaining, and/or creating the tools required for their research. ●While a variety of databases exist for investigators to find useful research tools these databases are usually: ○Specific to the type of resource, ○Too broad in scope, and/or ○Do not include newly developed or unpublished models ●To accelerate NF research, we are building the NF Research Tools Database, a database and companion web application to store and explore information about model resources specifically relevant to the NF community. ●The database will include key attributes for each resource and contributed observational data from publications and the research community. ●The database development consists of three phases (Figure 1): ○Design (current phase): Generation of a prototype database website. ○Pilot: Visitors can search and explore the contents of the database through the website. ○Long-term Development: Members of the NF community will be able to submit resource attributes or observations through a user friendly submission process. Acknowledgements The project team would like to thank Ljubomir Bradic, Stockard Simon, Bruce Hoff, Jay Hodgson, Kevin Boske, and Ryan Luce for helpful discussions regarding the design and development of this application. Icons made by Eucalyp from www.flaticon.com. This work is supported by the Gilbert Family Foundation. Conclusions & Future Directions ●GFF and Sage Bionetworks have made significant progress in developing a prototype tools database and companion web application for NF1 research resources. This resource could be a one-stop-shop for learning about the various experimental tools that have been generated by the NF1 research community ●After the prototype phase, we plan to expand the scope of this database to include NF2 and schwannomatosis-related resources ●We encourage feedback from the research community, particularly: ○What NF1-relevant animal models, cell lines, antibodies, genetic reagents, and biobanks you would like to see listed in the database. ○What types of research resource attributes you consider when, for example, selecting a cell line for an experiment. ○Whether you would be likely to contribute observational information about a research resource to a database like this. ●We are recruiting testers to participate in an upcoming evaluative design study. Please contact nf-osi@sagebionetworks.org if you are interested in participating in this study (Q4 2021) or contributing information about an NF1 research resource! Evaluating External Data Sources & Prior Work Designing a Data Model Identifying Use-Cases Prototype Design & Evaluation ●GFF developed an alpha version of the database, incorporating tools utilized within GFF research programs and soliciting feedback from their awardees on how to best classify and characterize each tool. ●Sage then condu	poster
In Situ Origins of Hot Jupiter Isolation Brandon Radzom1, Songhu Wang1, Bonan Pu2 1Indiana University, 2Cornell University • Outstanding issue: Hot Jupiters are more observed to be more isolated than warm Jupiters • Context: • Widespread prevalence of super-Earths in compact multiple-planet systems • Super-Earth pairs packed near the boundary of Hill instability (Pu & Wu 2015) • Most exhibit “peas in a pod” structure (Weiss et al. 2018) • Many are sufficiently massive to trigger runaway accretion (Lee et al. 2014; Batygin et al. 2016) • Our work: Use N-body simulations of mass-boosted super-Earths to demonstrate that in situ formation naturally produces observationally isolated hot Jupiters and warm Jupiters with nearby low-mass companions Introduction N-body Simulation Set-up References: Batygin, K., Bodenheimer, P. H., & Laughlin, G. P. 2016, ApJ, 829, 114; Lee, E. J., Chiang, E., & Ormel, C. W. 2014, ApJ, 797, 95; Millholland, S. C., He, M. Y., & Zink, J. K. 2022, arXiv e-prints, arXiv:2207.10068.; Pu, B., & Wu, Y. 2015, ApJ, 807, 44; Weiss, L. M., Marcy, G.W., Petigura, E. A., et al. 2018, AJ, 155, 48, Main Results Our final systems exhibit three key properties (Figure 1): 1. Hot Jupiter Isolation. Period ratios of our hottest Jupiters (𝑃< 5 days) relative to their nearest companions are typically larger than those of warm Jupiters (by a factor of ~2). Thus, a large fraction of hot Jupiters' companions would not yet be detectable through transit timing variations or transit searches. 2. Dynamical Sweet Spot. Inner companions rarely survive for the hottest Jupiters but are seldom destroyed for hot Jupiters in the dynamical “sweet spot” (5 < 𝑃< 7 days). This sweet spot marks a dramatic drop in the average period ratio and a transition to inner companion configurations. 3. Mirrored Architectures. Our hot and warm Jupiter systems mirror each other— inner companion period ratios steadily increase with giant period while outer ratios tend to decrease. Step 1: Generate Stable Peas-in-a-Pod Systems We generate 200 peas-in-a pod systems, each with eight super-Earths orbiting a solar mass star. We then boost the mass of one planet per system to 1 Jupiter mass (MJ), driving instability, and integrate to 𝑡= 10 Myr. Step 2: Provide Mass Boost Dynamics: The giant’s position chiefly determines the final configuration since companion-companion collisions dominate (Figure 2). Hot Jupiter Isolation Dynamical Sweet Spot Mirrored Architectures Figure 2. Fraction of companions that avoid collisions & ejections (black squares; left axes) and average timescale for such events (blue shading; right axes) as a function of planet position, stacked for each giant’s position. Giant positions are shown schematically at the top of each panel (large black circles). Figure 1. Final giant period ratios with their nearest neighbor as a function of giant period, with orientations indicated (red rightward and blue leftward triangles). The mirror effect between our red and blue triangles may be astrophysical so long as peas-in-a-pod systems become truncated (see Millholland et al. 2022). A long planet chain exists outside the hot Jupiter, resulting in collisional cascade once two adjacent planets reach 𝑒≈𝑒𝑐/2. The hot Jupiter also merges with its nearest inner companion, leaving it isolated. The hot Jupiter has two inner companions which quickly merge and are then Hill stable for all time, since the Jupiter will “filter” 𝑒excitation. The number of companions on either side of the giant dictates the system’s fate, causing a mirrored effect for hot and warm Jupiter configurations. Sweet spot Innermost period @ 3-day pile- up Orbital eccentricities are bound by orbit-crossing value 𝑒𝑐 25 simulations run for each planet boosting position (25 × 8 = 200) Spacing based on the Equal Mutual Separation scheme— pairs initially Hill stable but pushed near 𝐾= 3.5 threshold after mass-boosting 𝑃~6 d 𝑃~4 d 𝑃~30 d	poster
sdfsafdsa Using digital tools and methods for a systematic literature review Representing social media interactions and meanings as knowledge graphs Creating a curation-enabled social media research archive The Connective project A three-year EU-funded research project (2020-2023) aiming to: Reveal how memory practices on social network sites inside and outside Lithuania, mediated by contested heritage, enable the construction of multiple collective identities. Advance digital curation approaches to social media data and its future preservation and access for research. 2. Based on the ontology, we established a property graph schema using the Cypher query language to design and implement a Neo4j database of social media conversations on Lithuanian heritage, memory and identity. We adopted Open Archives Information System (OAIS) definitions of Submission, Archival, and Dissemination Information Packages, to ensure integrity and authenticity of research data collected from social media platforms, while also ensuring their intelligibility in the research process. Digital resources, methods and tools in the research lifecycle The Connective Digital Memory in the Borderlands project We used the Publish or Perish reference collection software to conduct 20 faceted queries on Google Scholar, based on combinations of Boolean query expressions for difficult heritage and social media platforms. The queries yielded 1,201 documents. Costis Dallas, Ingrida Kelpšienė, Rimvydas Laužikas Connective Research Group, Faculty of Communication, Vilnius University This poster reports on research conducted as part of “Connective digital memory in borderlands: a mixed-methods study of cultural identity, heritage communication and digital curation on social networks”. The Connective project was funded by the European Social Fund under grant agreement 09.3.3-LMT-K-712-17-0027 with the Research Council of Lithuania (LMT-LT). 11 researchers 9 themes 72 topics 4 languages 25,455 Facebook threads 264,954 messages 93,551 users 75 interviews Investigating the semiotic circulation of agency through knowledge graphs Extending nexus theory to show how attitudes on Soviet heritage move across social media, users and references to the dissonant past Investigating propagation across Neo4j person and message nodes Analyzing digital memories and perceptions of the past through qualitative content analysis Examining how Lithuanian everyday life and culture during the 1990s is represented on social media through identifications and memes Using MaxQDA and Neo4j for content and critical discourse analysis Comparing discourse constructs in actual and ChatGPT-produced social media content Investigating the use of ChatGPT to analyze and produce speculative SNS conversations on Lithuanian contested heritage Kelpšienė, Ingrida, Donata Armakauskaitė, Viktor Denisenko, Kęstas Kirtiklis, Rimvydas Laužikas, Renata Stonytė, Lina Murinienė, and Costis Dallas. 2023. ‘Difficult Heritage on Social Network Sites: An Integrative Review’. New Media & Society 25 (11): 3137–64. https://doi.org/10.1177/14614448221122186. Kirtiklis, Kęstas, Rimvydas Laužikas, Ingrida Kelpšienė, and Costis Dallas. 2023. ‘An Ontology of Semiotic Activity and Epistemic Figuration of Heritage, Memory and Identity Practices on Social Network Sites’. SAGE Open 13 (3): 1–25. https://doi.org/10.1177/21582440231187367. Laužikas, Rimvydas, and Costis Dallas. 2024. ‘The Message Is the Agent: Nexus and Semiosphere in Social Media Communication’. In Semiotics and Visual Communication IV: Myths of Today, edited by Evripides Zantides and Sonia Andreou. Cambridge: Cambridge Scholars Publishing. Publications https://doi.org/10.5281/zenodo.10886535 Entities Relationships Deposit Thread Message Agent Topic PART_OF SHARED_FROM RESPONDED_TO FOLLOWED_BY REACTED_TO POSTED DISPLAYS CONNECTED_AS IN_CONTEXT REFERS_TO 1. We built a theory-laden CIDOC CRM-compatible ontology to represent how social media users belonging	poster
An Analysis of Disabled Accessibility Transportation in the City of Chicago Manuel Luna Jr, Industrial Design, University of Illinois Chicago Dr. Joseph Hoereth, UIC — Institute for Policy & Civic Engagement (IPCE) According to the Regional Transportation Authority (RTA), all CTA and Pace buses are 100 percent accessible (RTA, 2023). The Americans with Disabilities Act holds these transportation systems to provide accessible features such as wheelchair securement areas, ramps, priority seating, and visual displays. In reality, 76% of stations are actually functional. The city of Chicago is constantly expanding their stations, not focusing this effort on the already established stations. Funding is going towards new station projects when some of the funding should be used for fixing the old stations that need it. Chicago Accessibility Compliance Program (CACP): The CACP focuses on ensuring that public spaces, transportation systems, and municipal buildings comply with accessibility standards outlined in the Americans with Disabilities Act (ADA). This initiative involves conducting audits, implementing necessary renovations, and providing resources to enhance accessibility for individuals with disabilities throughout the city. Chicago Business Leadership Network (CBLN): The CBLN collaborates with local businesses to promote inclusive hiring practices and provide support to employees with disabilities. Through education, training, and advocacy, the CBLN aims to increase workforce diversity and create employment opportunities for individuals with disabilities. Home Accessibility Program: This program provides financial assistance and incentives to property owners for retrofitting existing housing units to meet accessibility standards. By offering grants and resources, the city encourages the creation of accessible living environments for individuals with disabilities, thereby enhancing housing options and accommodation. These policies and initiatives reflect the City of Chicago's commitment to promoting inclusivity, accessibility, and empowerment for individuals with disabilities. By addressing various aspects such as infrastructure, employment, housing, and community support, Chicago strives to create a more inclusive and equitable environment for all its residents. BACKGROUND POLICY INITATIVES RECOMMENDATIONS RESEARCH OBJECTIVE METHODOLOGY FINDINGS • Increased funding for advocacy efforts from disability rights groups would significantly enhance their capacity to promote accessibility and inclusivity for individuals with disabilities. This funding could support initiatives such as grassroots organizing, public awareness campaigns, legal advocacy, and lobbying efforts aimed at influencing policymakers and stakeholders. • Implementing and upholding inclusive design standards and infrastructure would greatly bolster advocacy efforts for accessibility from disability rights groups. By ensuring that public spaces, buildings, transportation systems, and digital platforms are universally accessible, these standards not only remove physical barriers but also validate the rights and dignity of individuals with disabilities. This research seeks to examine the way the City of Chicago addresses issues of accessibility when it comes to people with disabilities and means of transportation. By analyzing existing policies, infrastructure improvements, and community engagement initiatives, this study aims to shed light on the effectiveness of current strategies in enhancing mobility and inclusivity for individuals with disabilities within the city's transportation network. Additionally, it seeks to identify potential areas for improvement and recommendations for fostering a more accessible and equitable transportation system for all residents of Chicago, regardless of ability. Introduction: The rights and well-being of individuals with disabilities have increasingly gained attention in policy circles and societal discourse. In urban environments	poster
www.postersession.com g Remote sensing has been used in many environmental studies because of its capacity to provide information rapidly on large and hard-to-reach areas. Recently, many programmes such as ASTER, Landsat and Copernicus Sentinels have provided satellite imagery of both high temporal and spatial resolutions free of charge. These data, combined with fieldworks and geophysical measurement , can lead to the finding of solutions for modern challenges such as climate change, natural hazards and increasing population growth. We used these technologies in a region which is both sensitive to and vulnerable to these phenomena, the karst environment of the Tabular Middle Atlas (TMA) of Morocco, in order to study the vulnerability of its natural water reserves . The TMA of Morocco contains an important water reservoir, located in Liassic carbonate rocks (dolomite and limestone), and used for everyday activities in cities such as Agourai, Fez, El Hajeb, Ifrane and Meknes. Because of its importance and the value it holds in the economy of the region it has been described as château d’eau. The most recent studies conducted in this region show that water quality is deteriorating due to anthropologic activities and natural processes. The present study proposes the use of earth observation, geophysical methods and free available data to map various forms of karst (avens, dolines, poljes...) and fault systems; these are the most fragile hotspots where the water reservoir can be easily penetrated in this karst system, with pollutants infiltrating and reaching groundwater and eventually identify most vulnerable areas. We intend to answer the question related to the part played by each fracture system, in order to find out which one is responsible for the infiltration of surface water and consequently is contributing to the development of sinkholes, and also to find out which system is draining water from the Causse to the basin. The aim of this study is to enhance the understanding of the hydrogeological system of the TMA, to improve the fracture database, to explore the profitability of new methodology combining space technology, applied geophysics and ground-based field work, and to establish a complete picture of vulnerable areas where sinkholes and human activities are degrading the quality of groundwater. There are three priority questions to be answered: -What is the direction of the fault systems involved in water infiltration, and probably led to the development of different karst landforms? -What is the predominant location of the sinkholes responsible for the turbidity and chemicals observed in water springs? -Where are water-soluble substances such as fertilizers, pesticides and herbicides accelerating carbonate dissolution due to human activities? Methods and materials Conclusions A.Muzirafuti1, M. Boualoul 1, G.Randazzo 2 , A. Allaoui1, S. Lanza 2, H. El Ouardi3, H. Habibi3, H. Ouhaddach3 1 Team of applied geophysics, Nat Ress. and Heritage, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco 2 Section of Earth Sciences, Dept. of Math and Computer Science, Physical Sciences and Earth Sciences, Univ. of Messina. Via F. Stagno d'Alcontres, 31 98166 - Sant'Agata di Messina, Messina, Italy – 3 Team of tec mapping, Dept. of Geology, Fac. of Sciences, University of Moualy Ismail, BP. 11201 Zitoune, Meknes, Morocco - Synthetic map of various karst landform location Fieldworks conducted in numerous locations around major faults, water springs and on different karst landforms helped us validate remote sensing results. We noticed that a big number of sinkholes are located in fractured carbonate rocks in low laying areas, some of them were identified in agricultural areas filled with basalts or clay sediments. Structural study conducted on carbonate fractures revealed that 37 % represent NE-SW fault system while 22% and 30 % represent Sub-meridian and NW-SE Fault faults systems resp	poster
SST CCI Phase-II Requirements for Sea Surface Temperature data sets for Climate Research and Services Nick Rayner, Met Office Hadley Centre, UK SST information is needed by almost all applications in climate research and by many climate service activities. The needs of these diverse fields are varied and can seem confusing without undertaking a systematic user requirements gathering exercise. The ESA Climate Change Initiative SST project has recently reviewed requirements for climate SST data sets from a wide range of applications in climate science and services; this updates its assessment undertaken over five years ago. Responses were received from scientists in 20 countries in North and South America, Europe, Asia, Africa and Australasia. A selected, preliminary analysis of responses is presented here; the final analysis will be presented in the updated User Requirements Document (see http://www.esa-sst-cci.org/ over the coming months). On what kind of grid would you like the data? Other here included: cubed sphere; ORCA (NEMO) grid; and equal area. Please classify this application into one or more of the following applications/interests. Other here included: climate feedbacks; Combined historical, near real-time, and seasonal applications; air quality modelling; comparison with in-situ; interpretation and analysis of hydrographic data; fisheries; for assessing processes; atmospheric chemistry; analysis of relationship between SST and crop productivity and drought; responses of marine top predators to climate change; global numerical weather prediction and high-resolution numerical weather prediction; climate impact model evaluation; ocean heat content comparison; and calibration of proxy data. On what data level does the application require observations? For your application, is it more useful to have all SSTs for the same local time or the same universal time? What spatial coverage is required? What is the temporal coverage needed for your application? How quickly you need data: Is the concept of an interim climate record important to your application? Here respondents gave responses between less than one day and 30 days. SST depth. Providers of satellite SST products variously aim to report temperatures for either the radiometric skin depth they observe or for sub-suface depths. For your application, which type(s) of SST is (are) most relevant? Other included SST1m. The SST CCI project will make Level 2 and Level 3C products available in a flexible format containing information enabling users to derive the SST and its uncertainty adjusted to different depths and times appropriate to their needs. We also propose to make available a standard product file which provides information in a simpler-to-use form. This standard file would contain SSTskin at the observation time, plus one other adjusted SST If you would use this, which combination of adjustments is most relevant to your application? Other here gave no specific alternatives Is your application sensitive to locally-correlated errors (correlated within synoptic scales and uncorrelated beyond)? If SST uncertainty information were to be provided as a parametrised covariance matrix, would you use this? If SST uncertainty information were to be represented by an ensemble (a set of plausible realizations of each SST field which span the uncertainties in the data), what size of ensemble would you need for your application (how many members)? not applicable 3 to 10 10 to 50 50 to 100 100 need guidance How would you like quality/confidence information to be communicated? Other here included requests for uncertainty information or an ensemble only and not to include flags as well. What information would you like to be within the data files? Other here included: gap filled or no gap filled / how?; info on anomalously cold data; data points that may contain extreme upwelling; and information about difference w.r.t. adjacent pixels. What other ancillary data from external sources	poster
www.rethinkaction.eu This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101037104 A platform to support local land-use decision making. Objective The main objective of RethinkAction is to engage citizens and decision-makers to participate in the energy transition and actively support climate adaptation and mitigation. Six representative case studies form the backbone of the RethinkAction project, covering the main regional differences related to climate change. Together with our End-User-Community we create an Integrated Assessment Platform. The user-friendly platform will empower citizens, stakeholders, and decision-makers to analyse climate change and incorporate climate action into the decisions that will affect our lives in the coming decades. Analysis at EU / global level Analysis at local level Land use-based Adaptation and Mitigation Solutions (LAMS) catalogue High-resolution climate data and land use maps. Climate change impacts and risks in each case study Land use-based Adaptation and Mitigation Solutions catalogued at local, EU and global scales Multiscale evaluation framework: 1) Future scenarios consistent across scales 2) Local system dynamic mo- dels for the integrated assessment of solutions 3) An upscaling function for solutions to EU and global scales (WILIAM IAM). • • • 1 Diagnosis 2 LAMS feasibility 3 Simulati on Interested? Engage! Help to make high-level information on land-use and climate change more accessible to people’s lives. Join our End-User-Community: Help to shape the direction in which RethinkAction is to be further developed. Expand and internationalise your professional network. Receive exclusive invitations to work meetings, training sessions and conferences organised by the project consortium. • • • What would happen if the LAMS assessed at local level…. …would be applied at EU / global level in all feasible locations? Upscaling solutions Simulati on with system dynamics integrated assessment model [WILIAM] An impression of the platform	poster
1 INTRODUCTION Depuis des décennies, la Station Biologique de Roscoff suit la diversité de s communauté s planctonique s a u larg e de Roscoff, avec des prélèvements bimensuels sur les si tes "Estaca de" et "SOMLIT-Asta n" , au Nord -Es t de l 'Îl e de B atz. Plusi eurs mét hodes sont utilisées pour dénombrer les cellules , d ont la micro scopie o ptiqu e po ur les e sp èc es > 20 µm , et la cyt omé trie en fl ux p our les esp èces <20 µm. La cy tom étrie en flu x permet de distinguer les groupes fonctionnels suivants : (i) les cyanobactéries du genre Synechococcus, (ii) les picoeucaryotes photosynthétiques, (iii) les nanoeucaryotes photosynthétiques (iv) les algues Cryptophytes (v) les bactéries et (vi) les virus marins Les données de diversité phytoplanctonique de Roscoff obtenues par microscopie optique on t déjà été bien étudiées par le laboratoire et ont m is en éviden ce u ne dynamiq ue saisonniè re t rès marquée avec des successions d’espèces au c ours de l’année (Caracciolo et al. 2022). Ce projet, focalisé sur les données obtenues par cytométrie en flux avait pour objectif : (1) d e fair e u n inventair e de s donnée s disponible s et d es protocol es utilis és po ur l es collecte r, ( 2) de détermi ner les dynamiq ues saisonniè res des principaux groupes fonctionnels distingués po ur le site SOMLIT- Ast an e t ( 3) de déter min er si les blooms saiso nni ers de Synecho coccus avaient changé de date au cours des deux dernières 20 ans de données Échantillonnage et analyse de la mer à la cellule Actuel Protocole 2 Anciens FACSCanto, FACSCan Flash frozen Sans Pluronic + Glutaraldéhyde (fixateur) + Pluronic (surfactant) Echantillonnage (Neomysis) Congélation (-20°C) Congélation (-80°C) Conservation Niskin bottle Picoeucaryotes Analyse des abondance s des group es taxonomiques Cytogramme Fluorescence Side Scatter (SSC) Synechococcus Bactéries Nanoeucaryotes + 5µl billes Polysciences fluoresbrite® Analyse (laboratoire) Microgouttelette chargée contenan t 1 seule cellule FACSort Détecteur et photomultiplicateur SSC : taille Fluorescence : naturelle ou fluorochrome Cytométrie en flux : Dynamique saisonnière au site SOMLIT-Astan 7 Trait de filet (eau de Roscoff) diatomées Synechococcus ? nanoeucaryotes photosynthétiques ? picoeucaryote photosynthétique ? © SBR 6 Cyanophage et Synechoccocus infectée © Sophie Le Panse, Plateforme MERIMAGE (SBR) 48°46'40.1"N 3°56'15.0"W 48°43'55.9"N 3°58'58.0"W 3 4 OUI Fig. 5. Variations saisonnières des abondances des 5 groupes fonctionnels sur la période d u 12/01/200 7 a u 18/12/201 9 (1 2 an s e t 1 1 mois ). Donné es issu es de la ba se PELAGO S, s ite SOMLIT-Astan surface. (d) Picoeucaryotes (e) Nanoeucaryotes (b) Bactéries (c) Cryptophytes (a) Synechococcus Pico : 0.2-2 µm Nano : 2 – 20 µm Micro : 20-200 µm Phytoplancton → diversité de taille : 500 nm 5 8 Fig. 9. Variations saisonnières des abondances de virus HNA (2013- 2020), site SOMLIT-Astan surface. Intéractions virales Abondance virale (cellules/mL) Synechococcus est la cible de certains virus marins. Au site Astan, en surface, l'abondance des virus HNA (High Nucleic Acid content) qui ciblent Synechococcus, mais aussi des picoeucaryote s photosynthétiqu es (communicati on personnel le de AC Baudo ux) va rie de f açon saisonni ère, ave c un pi c en juin-juil let, pér iod e de développ ement des pico- et nanoeucaryotes. 500 nm 200 nm LIMITES & PERSPECTIVES → Biais potentiels dus au changement de protocole des données PELAGOS → Série temporelle courte : description possible, mais conclusions limitées → Échantillonnage tous les 15 jours insuffisant pour suivre les blooms d’organismes unicellulaires à cycle de vie court (de quelques heures à quelque s jours) De nombreuses pistes sont possibles pour explorer davantage cette communauté. Par exemple, des données de fluorescence et de PA R (Rayonnemen t Photosynthétiquemen t Actif ) son t disponible s su r l a ba se SOMLIT. Ces données pourraient révéler des changements physiologiques c hez	poster
Resolving Surface Features on M Dwarfs that Host Transient Corotating Material Ben Tofflemire1,†, Adam Kraus1, Andrew Mann2, Greg Mace1 1The University of Texas at Austin, 2UNC Chapel Hill †51 Pegasi b Fellow RIK 12 Toy Model Complex Periodic Variables Complex periodic variables (CPVs) exhibit narrow dimming events with variable morphologies and depths that are periodic with the stellar rotation. Dimming events emerge and disappear stochastically. CPVs are predominantly young (<~200 Myr), low- mass (M<0.4 M⨀), and rapidly rotating (P<1 d). The most likely explanation for this behavior is magnetically confined material orbiting in co-rotation with the star [1,2,3]. Monitoring with IGRINS We have monitored four CPVs in Upper Sco using the IGRINS spectrograph ([4,5], simultaneous H and K at R~45,000). Here, we showcase the results for RIK 12 ([6], M2.5 SpT, 5-10 Myr, Prot = 0.49 d, G mag = 13.8, K mag = 9.7) We reconstruct the stellar absorption profiles by computing spectral-line broadening functions using the saphires package [7]. We find: • Large rotational velocities (vsini>150 km/s), consistent with edge on viewing angles • Evidence for large and evolving spot features • No significant radial-velocity variability Modeling Surface Features The cadence and baseline of our observations do not allow for a full surface reconstruction. Still, we can use a toy model to investigate characteristics of surface features that are consistent with our observations. We find the amplitude of the line-profile deviations are challenging to reproduce with typical spot- photosphere surface brightness ratios in the NIR (~0.5). The depth and bread of the deviations are improved when incorporating polar spots. Our most extreme cases likely require obscuring dust. In summary, our spectra suggest the presence of: • Large, high-contrast (dark) spots near equator • Large polar spots • Potentially, obscuring dust Our sparsely sampled spectra highlight CPVs as prime candidates for future Doppler tomographic studies to fully reconstruct the stellar surface, and to measure the orientation and size of the transiting material. Resolution Element Rotational Phase Rotation Periods since K2 Signature of Dark Spots (or Obscuring Material) No evidence for RV variability Flux compared to a homogeneous surface Typical Residual Depth vsini Acknowledgements & References BMT acknowledges the Heising-Simons Foundation, and TESS Cycle 3 & 4 Guest Investigator Grants (80NSSC21K0780, 80NSSC22K0302) [1] – Bouma et al. 2024, AJ, 167, 38 [2] – Stauffer et al. 2017, AJ, 151,60 [3] – Zhan et al. 2019, ApJ 876, 127 [4] – Mace et al. 2016, SPIE, Vol. 9908 [5] – Mace et al. 2018, SPIE, Vol. 10702 [6] – Rizzuto et al. 2015 MNRAS,448, 2737 [7] – Tofflemire et al. 2019, AJ, 148, 245	poster
1 2 3 4 5 6 7 8 BTSA 1 et 2 Licence de biologie générale 2 et 3 Master 1 et 2 en Microbiologie Doctorat Nutrition animale, parasitisme et environnement BTSA 1 et 2 Classe préparatoire ATS* École d’ingénieur Agroalimentaire- Agronomie Doctorat Nutrition animale et qualité des produits laitiers Doctorat Microbiologie et santé animale Doctorat Nutrition animale et qualité des produits laitiers École d’ingénieur en Agriculture avec classes préparatoires intégrées Master 1 et 2 en Sciences Animales Licence de biologie générale 1, 2 et 3 Master 1 et 2 en Microbiologie Doctorat Sélection génétique et santé animale École d’ingénieur en Agriculture avec classes préparatoires intégrées Lucie Laurianne Valentin Blandine Des parcours variés vers le doctorat (bac+8), à toi de créer le tien ! Bac ATS : Adaptation de Technicien Supérieur *BTSA : Brevet de Technicien Supérieu r Agricole Clément Centre Auvergne Rhône Alpes - Theix Route de Theix 63122 Saint-Genès-Champanelle, France Tel.: +33 (0)4 73 62 40 00	poster
Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation in Saccharomyces cerevisiae Faeze Saatchi1, Ann L. Kirchmaier1 1 Department of Biochemistry and Purdue Center for Cancer Research , Purdue University, West Lafayette, IN 47907 Current address: Department of Internal Medicine, Kidney Cancer Research Program, UT Southwestern Medical Center, Dallas, TX 75235 Abstract Conclusions Introduction me me Ku70/80 me me FH Ku70/80 H2A H2A H2A.Z H2A.ZH3K36H3K36 FH H2A H2A.Z H2A H2A.Z Malate Fumarate KDM2B Malate Fumarate Figure 1. Upon DNA damage, fumarase (FH) is recruited to sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. Fumarate generated by DSB-associated FH acts as an inhibitor of α- ketoglutarate-dependent histone demethylase KDM2B causing an increase of H3 K36 methylation at DSBs. This, in turn, promotes binding of Ku70/80 to DSB ends and enhances DSB repair by NHEJ. Sensitivity of htz1Δ mutants to DNA replication stress caused by HU is suppressed by high cellular levels of the metabolite fumarate (achieved by addition of exogenous fumarate or deletion of Fumarase, Fum1p) Figure 3. Cells with genotypes as indicated were grown overnight in rich (YPD) medium, then 3 ul of 10-fold serial dilutions were spotted onto YPD medium containing the indicated concentrations of fumarate and/or HU, and incubated at 30°C for 2 days prior to imaging. Loss of JmjC domain-containing histone demethylase Jhd2p suppresses the sensitivity to DNA replication stress of htz1Δ mutants. Results Our study uncovers links between the metabolic enzyme fumarase plus the metabolite fumarate and chromatin modifications during DNA damage response in Saccharomyces cerevisiae. In mammalian cells, fumarase becomes enriched at sites of double stranded break (DSB) through interaction with the histone variant H2A.Z. At DSBs, fumarase promotes DNA repair by nonhomologous end joining (NHEJ) by local production of fumarate which in turn acts as an inhibitor of KDM2B, a H3 K36-specific histone demethylase. We have demonstrated that treatment with hydroxyurea (HU), which creates stalled replication forks by depletion of nucleotides, leads to upregulation as well as nuclear enrichment of Fum1p. We have also shown that increased cellular levels of fumarate (upon deletion of FUM1 or addition of exogenous fumarate) suppresses the sensitivity to HU in htz1Δ mutants in a manner that is independent of modulating nucleotide levels. In fact, fumarate confers resistance to HU in htz1Δ mutants by inhibition of the H3 K4-specific histone demethylase Jhd2p, and increasing H3 K4 methylation levels. Sensors and mediators of the DNA replication checkpoint were required for fumarate- dependent resistance to HU in htz1Δ whereas factors involved in processing of regressed replication forks were dispensable. Together, our findings imply that high cellular levels of fumarate support processing of replicative intermediates by regulation of histone methylation, thereby promoting genome integrity. Fumarase is induced and becomes enriched in the nuclear fraction upon exposure to hydroxyurea (HU) Fumarate modulates levels of JDH2-dependent H3 K4 methylation. Figure 4. Strains with indicated genotypes were analyzed in serial dilution growth assays as described in Figure 3 YKu70p is not required for suppression of sensitivity of htz1Δ mutants to DNA replication stress by fumarate. Figure 2. Yeast expressing Fum1-GFPp were incubated in the absence or presence of 200 mM HU at 30°C for 3 hr. Whole cell extracts (A), or nuclear fractions (B) were analyzed by immunoblotting using anti-GFP, and anti-PCNA antibodies. A representative immunoblot and fold enrichment of Fum1p from two independent experiments is shown. Levels of Fum1-GFPp were normalized to levels of PCNA (loading control), then expressed relative to signal that was observed in the absence of HU, which was set to 1. Figure 5. (A) Enhancing histone methyl	poster
NuSTARConstrainstheOriginofGammaRays inRSOph Marina Orio1,2, G. Juan M. Luna3 1. U Wisconsin and INAF-Padova, 2. orio@astro.wisc.edu, 3. CONICET, Buenos Aires and Hurlingham Universities Introduction RS Oph is arguably the best known recurrent symbiotic nova. Classical and recurrent novae occur in white dwarf binaries. The outbursts are attributed to a thermonuclear runaway on the surface of the WD, that has accreted ma- terial from the binary companion. A radiation- driven wind follows, depleting the accreted enve- lope [1, 2]. The designation “recurrent” implies that the outburst is observed more than once over human life timescales, and in RS Oph case outbursts were recorded in 1898, 1933, 1958, 1967, 1985, and 2006. RS Oph is also a sym- biotic system, hosting a red giant M0-2 III mass donor companion [3, 4] in a binary with a 453.6 day orbital period [5]. The NuSTAR observation We obtained a Director Discretionary Time NuSTAR 40 ks exposure in the 3-79 keV range on 2021 August 17, day 10 of the outburst ( it was impossible to schedule the exposure earlier, when the source may have been harder). The X-ray ﬂux was expected from colliding winds, presumably the high velocity ejecta impacting the slow red giant wind. One of the most in- teresting facts of this phase is the gamma-ray ﬂux, measured with Fermi in the GeV range and with HESS up to tens of GeV [6]. During the NuSTAR observation, several short exposures were done with NICER. Most important, for the ﬁrst time, a nova was observed at the same time also in gamma rays with Fermi and with Cherenkov telescopes [6]. References [1] S. Starrﬁeld, F. X. Timmes, C. Iliadis, W. R. Hix, W. D. Arnett, C. Meakin, and W. M. Sparks. Hy- drodynamic Studies of the Evolution of Recurrent, Symbiotic and Dwarf Novae: the White Dwarf Com- ponents are Growing in Mass. Baltic Astronomy, 21:76–87, January 2012. [2] William M. Wolf, Lars Bildsten, Jared Brooks, and Bill Paxton. Hydrogen Burning on Accreting White Dwarfs: Stability, Recurrent Novae, and the Post- nova Supersoft Phase. ApJ, 777(2):136, November 2013. [3] Danuta Dobrzycka, Scott J. Kenyon, Daniel Proga, Joanna Mikolajewska, and Richard A. Wade. The Hot Component of RS Ophiuchi. AJ, 111:2090, May 1996. [4] G. C. Anupama and J. Mikołajewska. Recurrent no- vae at quiescence: systems with giant secondaries. A&A, 344:177–187, April 1999. [5] E. Brandi, C. Quiroga, J. Mikołajewska, O. E. Ferrer, and L. G. García. Spectroscopic orbits and variations of RS Ophiuchi. A&A, 497(3):815–825, April 2009. [6] H. E. S. S. Collaboration. Time-resolved hadronic particle acceleration in the recurrent nova RS Ophi- uchi. Science, 376(6588):77–80, April 2022. [7] Indrek Vurm and Brian D. Metzger. High-energy Emission from Nonrelativistic Radiative Shocks: Ap- plication to Gamma-Ray Novae. ApJ, 852(1):62, Jan- uary 2018. [8] Gary Wegner, Joseph P. Cassinelli, and George Wallerstein. Shockwave Models for the Outburst of the Repeating Nova, RS Ophiuchi. In Bulletin of the American Astronomical Society, volume 1, page 209, March 1969. [9] S. Orlando, J. J. Drake, and J. M. Laming. Three- dimensional modeling of the asymmetric blast wave from the 2006 outburst of RS Ophiuchi: Early X-ray emission. ApJ, 493(3):1049–1059, January 2009. Conclusions The low maximum temperature measured with NICER rules out that the site of the X-ray emission is the same as the site of the gamma-ray emission. In fact, the energetics of novae are such that the shock temperature may be in the hard X-ray range, but gamma rays due either to inverse Compton eﬀect (leptonic mechanism) or to particle acceleration in the shock (causing pion decay; hadronic mechanism) are only associated with a very hard X-ray spectrum, with conspicuous ﬂux up to 80 keV. The site of the gamma-ray emission was thus optically thick even to very hard X-rays. In the 40-79 keV range, we have upper limits of 3 ×10−4 cts s−1 in NuSTAR. Assuming an initial X-ray ﬂux above 10−9 erg cm−2, consistent with Fermi	poster
RESEARCH POSTER PRESENTATION DESIGN © 2012 www.PosterPresentations.com In developing countries, Clinical Research is considered a luxurious interest with lower priority. Ongoing studies show considerable gap in responses between developed countries where most research is conducted and developing countries where most of needy population is located. Background and Significance Purpose This process proved effective and necessitated developing tools for providing more comprehensive treatment roadmaps and tracking patients’ treatment milestones. Another advantage of applying the system is the improvement of medical team conduct knowing that their performance is being reviewed in what’s known as Hawthorne Effect. With the establishment of first research informatics unit in the region Monitoring process became live web-based activity where performance and survival can be monitored instantaneously. Method Within five years we’ve developed a model example for developing countries to improve clinical practice through integrating research methods and informatics. Dealing with all treatment regimens as research protocol with the integration of audit and feedback approach in the treatment process definitely improves treatment outcome most specifically at poorly established settings. Conclusion We demonstrate a case where practice was improved in a multi-disciplinary cancer center through setting the institution vision and objectives to be patient centered, research focused and outcome oriented. Research Clinical 2008 • Starting Protocol development and Monitoring Unit • Data collection using MS Excel 2008-2009 • Access databases (local) • Databases shared over network. 2009 • In-House development of Web-based application for electronic data capture. Each protocol is digitized. 2010 • Development of Web-based plug-in for mobile / handheld devices and real-time analysis. • Task manager • Cancer Registry 2011 • Violation Reporting / Patient safety 2012 • Joining RedCap open source Consortium • IRB submission and review online system • Research Online Training Management System. • Research and Clinical Pharmacy eLearning module 2007 • RIS: Radiology Information System. • PACS: Picture archiving and communicatio n system • LIS: Lab Information System 2007-2009 • Paper based patient charts. 2009 • Implementing Electronic medical Record System. Research Department, Children's Cancer Hospital 57357 - Egypt. Research Department, Children's Cancer Hospital 57357 - Egypt. A.S. Alfaar, M. Kamal, O. Hassanain, M. Sabry, S. Ezzat, S. Abouelnaga Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Advancing Clinical Oncology Practice in Developing Countries: Integrating Research Informatics for Continuous Process Improvement. Since the development of the Protocol Monitoring unit and the Research Department, a monitoring process has been established which identified violations and deviations from the developed clinical protocols with a continuous feedback to the attending treatment and research teams i.e. treating each treatment regimen as a research protocol. 2008 Paper File 2011 Electronic research systems Pictures are graphically manipulated for protecting patients’ privacy No Conflict Of Interest To Be Declared By Authors Telemedicine Live Stat’s The customized treatment protocols were developed through identifying key evidence-based practices, integrating it with research questions and local clinical expertise. Cooperation with international centers like St. Jude Children’s Research hospital and Dana Farber Cancer Institute as well as Children’s Hospital-Boston has supported our transition into an international center through benchmarking and training. Acknowledgement This Poster is Supported by Travel Grant From ESMO Contact Us: mohamedkamalpharm@gmail.com asamir@57357research.com msabrybakry@gmail.com N.B. The team is all MDs and Pharmacists No IT members. Portal Dashboar	poster
Eingangsformel Der Parlamentarische Rat hat am 23. Mai 1949 in Bonn am Rhein in öffentlicher Sitzung festgestellt, daß das am 8. Mai des Jahres 1949 vom Parlamentarischen Rat beschlossene Grundgesetz für die Bundesrepublik Deutschland in der Woche vom 16. bis 22. Mai 1949 durch die Volksvertretungen von mehr als Zweidritteln der beteiligten deutschen Länder angenommen worden ist. Auf Grund dieser Feststellung hat der Parlamentarische Rat, vertreten durch seine Präsidenten, das Grundgesetz ausgefertigt und verkündet. Das Grundgesetz wird hiermit gemäß Artikel 145 Abs. 3 im Bundesgesetzblatt veröffentlicht: Präambel Im Bewußtsein seiner Verantwortung vor Gott und den Menschen, von dem Willen beseelt, seine nationale und staatliche Einheit zu wahren und als gleichberechtigtes Glied in einem vereinten Europa dem Frieden der Welt zu dienen, hat sich das Deutsche Volk in den Ländern Baden, Bayern, Bremen, Hamburg, Hessen, Niedersachsen, Nordrhein-Westfalen, Rheinland-Pfalz, Schleswig-Holstein, Württem- berg-Baden und Württemberg-Hohenzollern, um dem staatlichen Leben für eine Übergangs- zeit eine neue Ordnung zu geben, kraft seiner verfassungsgebenden Gewalt dieses Grund- gesetz der Bundesrepublik Deutschland beschlossen. gegeben. Es hat auch für jene Deutschen gehandelt, denen mitzuwirken versagt war. Das gesamte Deutsche Volk bleibt aufgefordert, Die Deutschen in den Ländern Baden- Württemberg, Bayern, Berlin, Brandenburg, Bremen, Hamburg, Hessen, Mecklenburg- Vorpommern, Niedersachsen, Nordrhein- Westfalen, Rheinland-Pfalz, Saarland, Sachsen, Sachsen-Anhalt, Schleswig-Holstein und Thüringen haben in freier Selbstbestimmung die Einheit und Freiheit Deutschlands zu vollenden vollendet. Damit gilt dieses Grundgesetz für das gesamte Deutsche Volk. I. Die Grundrechte Artikel 1 (1) Die Würde des Menschen ist unantastbar. Sie zu achten und zu schützen ist Verpflichtung aller staatlichen Gewalt. (2) Das Deutsche Volk bekennt sich darum zu unverletzlichen und unveräußerlichen Men- schenrechten als Grundlage jeder menschlichen Gemeinschaft, des Friedens und der Gerech- tigkeit in der Welt. (3) Die nachfolgenden Grundrechte binden Gesetzgebung, Verwaltung vollziehende Gewalt und Rechtsprechung als unmittelbar geltendes Recht. Artikel 2 (1) Jeder hat das Recht auf die freie Entfaltung seiner Persönlichkeit, soweit er nicht die Rechte anderer verletzt und nicht gegen die verfassungs- mäßige Ordnung oder das Sittengesetz verstößt. (2) Jeder hat das Recht auf Leben und körperliche Unversehrtheit. Die Freiheit der Person ist unverletzlich. In diese Rechte darf nur auf Grund eines Gesetzes eingegriffen werden. Artikel 3 (1) Alle Menschen sind vor dem Gesetz gleich. (2) Männer und Frauen sind gleichberechtigt. Der Staat fördert die tatsächliche Durchsetzung der Gleichberechtigung von Frauen und Män- nern und wirkt auf die Beseitigung bestehender Nachteile hin. (3) Niemand darf wegen seines Geschlechtes, seiner Abstammung, seiner Rasse, seiner Sprache, seiner Heimat und Herkunft, seines Glaubens, seiner religiösen oder politischen An- schauungen benachteiligt oder bevorzugt wer- den. Niemand darf wegen seiner Behinderung benachteiligt werden. Artikel 4 (1) Die Freiheit des Glaubens, des Gewissens und die Freiheit des religiösen und weltan- schaulichen Bekenntnisses sind unverletzlich. (2) Die ungestörte Religionsausübung wird ge- währleistet. (3) Niemand darf gegen sein Gewissen zum Kriegsdienst mit der Waffe gezwungen werden. Das Nähere regelt ein Bundesgesetz. Artikel 5 (1) Jeder hat das Recht, seine Meinung in Wort, Schrift und Bild frei zu äußern und zu verbreiten und sich aus allgemein zugänglichen Quellen ungehindert zu unterrichten. Die Pressefreiheit und die Freiheit der Berichterstattung durch Rundfunk und Film werden gewährleistet. Eine Zensur findet nicht statt. (2) Diese Rechte finden ihre Schranken in den Vorschriften der allgemeinen Gesetze, den gesetzlichen Bestimmungen zum Schutze der Jugend und in dem Recht der persönlichen Ehre. (	poster
DIE STORY IN DEN DATEN Robert Köpke IfL Leipzig Unser Use Case Im Projekt arbeitet das IfL an der Entwicklung von Visualisierungsformaten und der kritischen Analyse von Biodiversitätsdatensätzen. Das IfL entwickelt (raumbezogene) Visualisierungen sowie Methoden des visuellen Storytellings, um komplexe Datensätze verständlich darzustellen und unterschiedleiche Zielgruppen zu adressieren. Girlitz im Blick Seit vielen Jahren führt der DDA das Monitoring häufiger Brutvögel durch, unterstützt von zahlreichen geschulten Freiwilligen. Diese Story beleuchtet, wie die gesammelten Daten verarbeitet werden und welche Schlüsse daraus gezogen werden können, insbesondere im Hinblick auf den rückläufigen Brutbestand des Girlitz. Sie erzählt von den langfristigen Erkenntnissen aus Jahrzehnten der Datenerhebung und zeigt, wie Technik die Arbeit erleichtert. Von Ruf und Realität Die Süßwasserfische Brachse und Äsche, obwohl häufig vorkommend, erleben einen Bestandsrückgang. Die länderübergreifende Auswertung von Bestandsdaten, wie sie das Projekt NFDI4Biodiversity vornimmt, ermöglicht es, solche Entwicklungen frühzeitig zu erkennen und Schutzmaßnahmen einzuleiten. Diese Story zeigt am Beispiel dieser Fischarten das Potenzial der einheitlichen Datenverarbeitung für den Biodiversitätsschutz. DATENGRUNDLAGE - Harmonisierter Fischmonitoring- Datensatz ZIELGRUPPE - Wissenschaftler :innen - Fachpublikum FORSCHUNGSFRAGE Kartographische Methoden zur Visua- lisierung von Unsi- cherheiten in Vorkom- mensdaten und deren Einfluss auf Interpretation und Entscheidungsfindung. DATENGRUNDLAGE - Testflächen Monitoring häufiger Brutvögel ZIELGRUPPE - Ausgebildete Helfer:innen - Breite Öffentlichkeit FORSCHUNGSFRAGE Wie können räumliche Analysemethoden ein- gesetzt werden, um Muster und Trends zu identifizieren? Data Storys Die Verwendung von digitalem Storytelling, das Karten, Infografiken und Bilder einsetzt, ist eine effektive Methode, um Inhalte für verschiedene Zielgruppen ansprechend zu gestalten. Möglichkeiten Verbesserte Entscheidungsfindung: Erleichtern das Verständnis komplexer Daten, unterstützen so umweltpolitische und wissenschaftliche Entscheidungen. Interaktive Lernerfahrung: Multimedia-Elemente wie Videos, interaktiven Karten und Animationen können Nutzer die Daten erfahren lassen. Forschung und wissenschaftliche Analyse: Kann neue Muster und Zusammenhänge in Biodiversitätsdaten kommunizieren. Herausforderungen Zeitliche Dynamik: Darstellung von zeitlichen Veränderungen und Aktualität Interdisziplinäre Integration: Zusammenführung von Expertenwissen Darstellung von Unsicherheiten: Um Fehlinterpretationen zu vermeiden und ein realistisches Bild zu vermitteln. Dateninterpretation und -verfügbarkeit: Sicherstellung der Genauigkeit, Aktualität und Vollständigkeit der Daten.	poster
Seminar für Ägyptologie und Koptologie (Re-)Konstruktion der Lübecker Aegyptiaca – Didaktische Perspektiven auf gegenständliche Quellen in der Ägyptologie Nina Wagenknecht, M.A. E-Mail: nina.wagenknecht@stud.uni-goettingen.de Erstbetreuung: apl. Prof. Dr. Heike Sternberg-el Hotabi, Seminar für Ägyptologie und Koptologie Zweitbetreuung: Prof. Dr. Michael Sauer, Seminar für Mittlere und Neuere Geschichte •Thema und Zielgruppe festlegen •Vermittlungsziele des Themas formulieren •Objekte auf Basis des Themas auswählen Thema und Zielgruppe der Ausstellung •Kontextualisierung von Verwendungsweisen und Datierung der Objekte •Rekonstruktion der Erwerbsumstände der Objekte Fachwissenschaftliche Sachanalyse •Erarbeitung der Umsetzungsformate unter Einbezug von Medienwahl, - wechsel und Barrierefreiheit •Ausarbeitung der digitalen Präsentation der Objekte in Microsoft Access Didaktische Analyse Methodisches Vorgehen Thema und Ziele der Arbeit Im Rahmen des Dissertationsvorhabens wird ein Online- Vermittlungskonzept für die nicht physisch ausgestellten Aegyptiaca der Völkerkundesammlung der Lübecker Museen erarbeitet. Zentrale Ziele dabei sind: • Die Übertragung methodischer Schritte zur Vermittlung gegenständlicher Quellen aus der Geschichtsdidaktik zur Erarbeitung zusammenhängender Lernmaterialien. • Erstellung eines Vermittlungskonzeptes thematisch ausgewählter Aegyptiaca unter Einbezug einer kritischen Reflexion der Sammlungsgeschichte. Materialbasis Inhalt der Sammlung: 338 Aegyptiaca (415 Objekte einschließlich Verluste). Erwartete Ergebnisse 1. Inhaltliches Ergebnis: Ein Online-Konzept, das einen ausgewählten Teil des Bestandes der Lübecker Aegyptiaca der Öffentlichkeit thematisch aufbereitet zugänglich macht und dabei die Verbindung der Objekte zur Sammlungsgeschichte der Völkerkundesammlung kritisch einordnet. 2. Methodisches Ergebnis: Systematische Erschließung neuer Formate der Wissensvermittlung auf Basis der Struktur von Bestandskatalogen, die auf weitere Sammlungen übertragen werden kann. Zeitphase Anzahl Beispiele für Objekte Paläolithische Zeit 49 Flint- und Hornsteinobjekte Prädynastische Zeit 40 Tonkrüge, Haarnadel, Schminkpalette Frühdynastische Zeit 9 Flintwerkzeuge Altes Reich 8 Modell-Opferteller Mittleres Reich 3 Koḥl-Gefäß Neues Reich 11 Grabziegel, Umschlagtuch, Wandbruchstück Spätzeit 96 Gewichtsteine, Kaurischnecken, Figur-Sockel Ptolemäische Zeit 20 Amulette, Öllampen, Ostrakon, Vogelmumie Römische Zeit 61 Würfel, Spinnwirtel, Schreibtafel, Brotstempel Frühislamische Zeit 6 Koptische Textilien Unklare Datierung 12 Skarabäen, Torso einer Königs-Statuette 19./20./21. Jahrhundert 23 Fälschungen, Repliken Literatur Falck, Martin von. 2011. „Museologischer Anspruch und museumsägyptologische Wirklichkeit“. In: Verbovsek, Alexandra, Burkhard Backes und Catherine Jones, Hrsgg. Methodik und Didaktik in der Ägyptologie. Herausforderungen eines kulturwissenschaftlichen Paradigmenwechsels in den Altertumswissenschaften. Ägyptologie und Kulturwissenschaft IV. München: Fink, 405–422. Germer, Renate. 2018. Die altägyptischen Objekte der Völkerkundesammlung der Hansestadt Lübeck: Ein Kurzkatalog zusammengestellt von Renate Germer, <https://vks.die-luebecker-museen.de/file/die_altaegyptischen_objekte__kompl_zusammengefasst.pdf> (Zugriff: Juli 2020). Röttele, Hannah. 2020. „Objektbegegnungen“ im historischen Museum: eine empirische Studie zum Wahrnehmungs- und Rezeptionsverhalten von Schüler_innen. München: kopaed.	poster
APPROACH The textile sector is undergoing a set of transformations to shift to a circular model. Within the framework of the TRICK project, an innovative approach to traceability and sustainability in textile supply chains has been developed. BACKGROUND OUTCOMES INDUSTRIAL PILOTS – CIRCULAR APPROACH The data model validation has been done through two pilots, one for the classical fashion segment and the other for the technical work-wear segment aiming to get the necessary data from a fragmented supply chain. The pilots began with the production of the goods made from virgin raw materials; the obtained garments, which usage was simulated, then were mechanically recycled. The obtained secondary raw materials include a percentage of the recycled goods; they were used to obtain garments of the same model whose characteristics were analyzed. The pilots started by an initial data gathering from the industrial users' internal system, a data validation and the mapping to the data model for its refinement. Then traceability reports were created by modeling data and reporting the product’s history. The collected data was also used to perform a PEF study across the whole supply chain. CONCLUSIONS AND NEXT STEPS The holistic approach to data collection covering traceability and sustainability data allows to easily meet the requirements from new normative: it is the case of ESPR and Digital Product Passport (DPP) enforcing a sustainable approach to production and, in parallel, more efficacy of the market surveillance authorities. The next steps will be to validate TRICK efficacy in collecting faithful data to fuel the creation of digital product passport contents from the fragmented textile supply chains. On this purpose a CEN Workshop process will be launched to share and improve such contents and contribute with a public pre- standardization activity to the establishment of a framework for collecting faithful data to support the DPP statements of the fashion firms. A Traceability Report for the data collections on the events is the TRICK response to the requirements emerged from the pilot supply chains to overcome the barriers, criticalities and needs highlighted by industrial partners involved in the project. In respect of the EPCGlobal EPCIS and UNECE event models, its Enriched Event-based Model: - offers a plurality of product and lot identification methods and a more detailed process step description with a shared taxonomy of manufacturing operations - supports the collection of the events from a wide range of heterogeneous systems, covering the many tiers of the supply chain - enforces a triangle of synergies among usual daily operations, blockchain technology and business services of a traceability platform and its disclosure policies. Enhancing Traceability and Faithfulness of Sustainability Data in the Textile and Clothing Supply Chain through Blockchain and a Standard Based Enriched Event Model Gessica Ciaccio (1), Carla Fité Galan (2), Piero De Sabbata (1), Arianna Brutti (1) (1) Italian National Agency for New Technology, Energy and Sustainable Economic Development, ENEA, TERIN-SEN-CROSS Laboratory, via dei Mille 21, 40121, Bologna, Italy (2) Polytechnic University of Catalonia (UPC), Systems and Processes lab of the Textile Research Institute of Terrassa (INTEXTER), Carrer Colom 15, 08222, Terrassa, Spain This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 958352 Fig. 5 Representation of a circular approach of the textile pilots in the TRICK project CONTACTS Gessica Ciaccio, gessica.ciaccio@gmail.com Carla Fité Galan, Carla.fite@upc.edu Piero De Sabbata, piero.desabbata@gmail.com In parallel the Transparency and Sustainability Report is the core of the Transparency and Sustainability data collection. It collects all the available non- operational data about Product and Organization and shares the data groups related to sustainability with specific	poster
Protect Bees, Save the Future I. Madaleno1, S. Branco1, students from 10th Grade Mechatronics1 1Externato Cooperativo da Benedita, Benedita, Portugal Abstract In this project students built a hive by adapting remote control systems for its internal environment (temperature and humidity) and external environment (door, fire, location). The solution was aimed at beekeepers, and anyone interested in getting started in the beekeeping industry. The main goals of the project were to facilitate the work of beekeepers and to improve the management, control and monitoring of hives. The solution created is feasible and satisfies the project's objectives. Keywords Automation; bees; electronics; robotics; sustainability.	poster
Direct Dark Matter Search with the CRESST-III Experiment Michael Willers on behalf of the CRESST collaboration Physik-Department and Excellence Cluster Universe, Technische Universität München, 85748 Garching The CRESST-III Experiment The CRESST (Cryogenic Rare Event Search with Superconducting Thermometers) [1, 2] experiment aims for the direct detection of Dark Matter (DM) particles via elastic scattering off nuclei in CaWO4. CRESST-III, the current stage of the experiment, searches for low-mass (M ≲10 GeV/c2) DM particles and ultimately aims to probe the parameter space down to the neutrino ﬂoor. The experiment is located in the Gran Sasso National Laboratory (LNGS), Italy, shielded against cosmic rays by ∼3600 m.w.e. of rock overburden. CRESST uses a multi-element target: scintillating CaWO4 single crystals operated as cryogenic detectors. Requirements for probing low-mass DM particles: • sub-keV energy threshold due to low momentum transfer to target crystal. • Low background rate in region of interest and good background suppression capabilities. CaWO4 target crystal: • Block-shaped CaWO4 crystal (20 × 20 × 10) mm3, Mass 25g. • Sensitivity gain due to reduced heat capacity and adapted TES design. Silicon-On-Sapphire light detector: simultaneous measurement of phonon- and light-signal enables particle identiﬁcation and background suppression. plain CaWO4 stick holding light detector Copper housing with reﬂective and scintillating inner surface (3M® Vikuiti foil [3]). Tungsten (W) TES Instrumented CaWO4 sticks (iStick) holding the CaWO4 target crystal: • events within the CaWO4 sticks are a potential back- ground for low-mass DM search. • instrumentation enables ef- ﬁcient veto of these events. • 3 iStick per module (1 read- out channel). Recent results from CRESST III phase 1 CRESST-III phase 1 started in summer of 2016 with an initial campaign to set-up and calibrate the detectors. The physics run of phase 1 started in September of 2016. • 10 detector modules installed. • 8 modules with TUM-grown crystals, 2 with commercial crystals. • 5 modules reached / exceeded design goal of 100eV nu- clear recoil energy threshold. • Detector A has lowest threshold in CRESST-III phase 1. First analysis of detector A • Data taking period: Oct. 2016 - May 2017 • Gross exposure (before cuts): 2.39 kg days • Blind analysis with non-blind training set (20% randomly selected, excluded from DM data set). Training set data used to deﬁne cuts. • Conservative analysis threshold of 100 eV. • Data quality (rate, stability, unphysical events) and coincidence (µ- veto and iStick) cuts applied. 79.5% survival probability at 100eV. • Limit on DM-nucleon cross-section calculated using Yellin’s optimal interval method [4] →sensitivity extended to lower DM masses (lim- ited by non-ﬂat background at low energies). The analysis of the full dataset as well as a low-threshold analysis are currently ongoing. Furthermore, the application of optimum ﬁltering to a stream of continuously acquired data is investigated with the goal of improving the trigger threshold of the detectors [5]. Data taken with detector A in the light yield - energy plane e−/γ-band recoils off oxygen recoils off tungsten dark matter acceptance region Low-energy spectrum of all events recorded with detector A CaWO4 crystal growth at TUM A high radio-purity of the CaWO4 crystals is es- sential for CRESST. In order to have full control of all crystal growth parameters, TUM has estab- lished a complete in-house CaWO4 crystal growth process [6]: • Powder production via solid state reaction or precipitation including chemical puriﬁcation (net reaction: CaCO3 + WO3 →CaWO4 + CO2). • Crystal growth in dedicated Czochralski fur- nace. • Annealing of grown ingots in pure O2 atmo- sphere. • Cutting and polishing of target crystals. In addition, recrystallisation of grown crystals is investigated as a measure to further improve the radio-purity of the CaWO4 crystals [7, 8]. Czochralski Furnace & raw	poster
Are You Catching Cosmic Rays or Just Checking Messages? Towards an Extremely Distributed Mobile Phone Cosmic Ray Observatory Carlyn Lee and Harvey Newman Division of Physics, Mathematics and Astronomy, California Institute of Technology, CA, USA Contact: Carlyn Lee Email: cblee@caltech.edu https://github.com/carlynlee/credo-api-tools/tree/playground/ References 1. Martın Abadi, et al., TensorFlow: Large-scale machine learning on heterogeneous systems, 2015. Software available from tensorflow.org. 2. Piotr Homola, et al., Cosmic-ray extremely dis- tributed observatory. Symmetry, 2020. 3. Jennifer Ngadiuba, et al., Compressing deep neural networks on fpgas to binary and ternary precision with hls4ml. Machine Learning: Science and Technology, 2(1):015001, Dec 2020. 4. Daniel Whiteson, et al., Searching for ultra-high energy cosmic rays with smartphones, Astroparticle Physics, Volume 79, 2016, Pages 1-9, ISSN 0927-6505. This project aims to design an architecture for applying Federated Learning (FL) to the analysis of cosmic ray event data collected through the Cosmic Ray Extremely Distributed Observatory (CREDO) project. CREDO gathers data from a global network of smartphones, enabling a large-scale citizen science initiative to study cosmic rays. The traditional approach of centralizing this data raises concerns about privacy and data ownership. We explore as a potential solution, allowing decentralized training of machine learning models directly on participants’ devices. We explore how FL can accommodate CREDO's requirements, such as handling heterogeneous data and robust model aggregation. We present our initial steps in designing an FL architecture tailored to the needs of the CREDO project, outline our architectural proposal, and discussing the potential benefits and the technical challenges. This sets the stage for future implementation and evaluation, aiming to enhance accountability and collaboration in scientific data analysis. Abstract Cluster Identification: Identified and visualized ten distinct clusters, each representing different events triggering the CREDO app. Device Comparison: Analysis reveals variance in detection patterns across devices, possibly indicating differences in device sensitivity or environmental conditions. Data Retrieval: Elasticsearch for query and image retrieval. Data stored as base64 encoded strings, corresponding to different devices and time frames. Image Processing: Decoded images from base64 format and resized to uniform dimensions for consistent analysis. Performed clustering based on extracted features using a pre-trained model, adapted to identify distinct patterns within the data. Cluster Visualization: Python scripts to compute and display the mean image for each cluster across multiple devices, enhancing interpretability of clustering results. Tools: Python (NumPy, Matplotlib, Pillow), ResNet50 deep learning model. q Visual analysis leveraged clustering and image processing techniques to dissect cosmic ray detection data. This approach highlighted variations across different devices and conditions, revealing possible patterns through visual data exploration. Such insights can be critical for refining detection strategies and enhancing the overall understanding of cosmic ray distributions. Future Work q Enhance Model Accuracy: Improve machine learning models and clustering precision. q Dataset Expansion: Enlarge dataset scope and integrate real-time data analysis for dynamic insights. q Federated Learning Implementation: q Local Model Training: Enable devices to train locally, sharing only model updates to minimize bandwidth use and enhance privacy. q Scalability: Use federated learning to keep data on local devices, addressing privacy concerns and managing large data volumes. q Collaborative Advancements: Combine insights across diverse devices, enhancing detection pattern accuracy and variety. q Managing asynchronous updates to models Discussion and Conclusions Objective: To analy	poster
RESULTS REFERENCES Geiser, E., Walker, K. M., & Bendor, D. (2014). Global timing: a conceptual framework to investigate the neural basis of rhythm perception in humans and non-human species. Front Psychol, 5. Gorgolewski, K., Burns, C. D., Madison, C., Clark, D., Halchenko, Y. O., Waskom, M. L., & Ghosh, S. S. (2011). Nipype: a flexible, lightweight and extensible neuroimaging data processing framework in python. Front Neuroinform, 5(3). Hanke, M., Halchenko, Y. O., Sederberg, P. B., Olivetti, E., Fründ, I., Rieger, J. W., ... & Pollmann, S. (2015). PyMVPA: a unifying approach to the analysis of neuroscientific data. Python in Neuroscience, 157. Kriegeskorte, N., Goebel, R., & Bandettini, P. (2006). Information-based functional brain mapping. Proc Natl Acad Sci USA, 103(10), 3863-3868. Stelzer, J., Chen, Y., & Turner, R. (2013). Statistical inference and multiple testing correction in classification-based multi-voxel pattern analysis (MVPA): random permutations and cluster size control. Neuroimage, 65, 69-82. INTRODUCTION • Humans are able to recognize a familiar rhythm, for example the rhythm of a song, independently of the tempo at which it is played. This is exemplary of the fact that auditory experiences comprise percepts of auditory Gestalt based on the rhythmic structure of sounds. • The pattern resulting from the relative temporal relationship between acoustic events is the basis for the perceptual emergence of temporal Gestalt. This Gestalt percept is invariant to the absolute temporal relationship between constituent acoustic events (Hulse et al. 1992). • It is unknown, where in the brain percepts of temporal Gestalt are generated. • A linear support vector machine (SVM) classifier was trained to differentiate activation patterns in functional Magnetic Resonance Imaging (fMRI) data to two different percepts, across different sensory constituents. • A searchlight analysis localized activation patterns specific to the temporal Gestalt. CONCLUSIONS →Based on brain activation patterns, a linear SVM classifier identified which relative temporal pattern had been presented. The classifier was trained across absolute temporal patterns (tempi) of sequences. -> The classifier had identified the neural activation pattern associated with the Gestalt percept. →Based on a searchlight analysis, activation patterns in the temporo-parietal junction (TPJ) (left and right hemisphere) and the inferior frontal gyrus (right hemisphere) discriminated between the two different temporally grouped percepts of temporal Gestalt. →Our findings reveal for the first time that both sensory and higher cortical areas encode temporal Gestalt. →The study provides an example of how we can tackle the neural basis of perceptual invariance using neuroimaging. METHODS EXPERIMENTAL SETUP • 19 volunteers underwent functional neuroimaging (fMRI). Where the rhythm plays: Machine learning decodes rhythm-sensitive cortices Michael P. Notter1,2, Michael Hanke3, Micah M. Murray1,2,4,5, Eveline Geiser1,6 1The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, Vaudois University Hospital Center and University of Lausanne, Lausanne, Switzerland 2Electroencephalography Brain Mapping Core, Center for Biomedical Imaging of Lausanne and Geneva, Switzerland 3Psychoinformatics lab, Institute of Psychology II, Otto-von-Guericke-University and the Center for Behavioral Brain Sciences, Magdeburg, Germany 4Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland 5Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA 6McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA SCANNER SETUP • 3T Siemens scanner; 64-channel head coil (coverage shown on the right) • TR of 2s; 365 volumes x 5 sessions; 33 slices (ascending order) PREPROCESSING • Pre-processing was done with Nipype (Gorgolewski et al., 2011): despiking (A	poster
CONTACT: =ichaelOWagenpfeil IrlangenOHentreOforOUstroparticleO+hysics michaelTwagenpfeilBfauTde SEEgALSO: StudyOofO+hotonOtransportOandOSi+= inOexternalOelectricalOfieldOinOnIX; &rTO+inO°Vi)OidqOV2?6 CharacterizationgofgVUV@ sensitivegSiPMsgforgnEXO MichaelgWagenpfeilO0forOtheOnIX;Ocollaboration5 id:g#439 PhysicsgbeyondgStandardgModel? •OTheOneutrinolessOdoubleObetaOdecayO 05opensOwindowOtoOphysicsObeyondOS= •OUreOneutrinosO=ajoranaOparticlesN •OHurrentO?νββOsearchesOareOsensitiveO 05toOaOhalf•lifeOofOaboutOv?-[OyearsO[v)O-] •OnIX;OplansOtoOincreaseOsensitivityO[1] ThegnEXOgdetectorO[1)O2] •OTime•projection•chamberO0T+H5OfilledOwithO~O6 tonsOOO 05ofOliquidOXenonO0°Xe5O–OenrichedOtoO~? :OinOv1[Xe •OHylindricObarrelOwithOaOdiameterOandOheightOofOvT1 m •O&etectorOsetOupOinOundergroundOlabOtoOshieldOfromO 05cosmicOraysO0likelyOS/;°UG)O[??? mweT5 •OSignalOdetectionOviaOchargeOreadoutOtilesO0endOcap5O 05andOVUV•sensitiveOSi+=sO0innerOcylinderOsurface5 •OHathodeOsetOtoO•6? kVOtoOproduceOaxialOdriftOfieldOO •OIxtensiveOradiopurityOscreeningOtoOconstrainOG8 •OQomogeneousOdetectorO#Omulti•parameterOanalysis Lightgdetection •OnIX;OsensitivityOdependsOonOphotonOtransportO 05efficiencyOandOphotonOdetectionOefficiency •ORnsideOwallOcoveredOwithO2 m-OofOVUV•sensitiveOSi+=s •O&etectionOofOv]3 nmOscintillationOlightOinO°Xe •O8oalqOv :OenergyOresolutionOatOµ•valueO0-263 keV5 •OStrongOrequirementsOonOSi+=OparametersO SiPMgcharacterizationgtestgsetups •OIHU+)OIrlangenO0&arkOnoise)O+&I)OVUVOreflectance5 •ORQI+)OGeijingO0QVObehaviour)OVUVOreflectance5 •OTzRU=7)OVancouverO0&arkOnoise)O+&I5 •OUU)OUlabamaO0VUVOreflectance5 •OStanfordO0+&I)OSi+=Otiles5 •OU=assO0+&I)O°Xe5 VariousgSiPMs •OQamamatsuOVUV1)OVUV2 •O7GKO/UVO-?v[O°7O#OST& 7romOleftOtoOrightq TestOsetupOatOIHU+)OtestOsetup atOStanford)OQVOsetupOatORQI+ •OzecordOSi+=OdarkO 05pulsesOatO•v??°H •O7itOpulseOtemplateO 05toOwaveforms •OUseOamplitude)O 05timestamp)OriseO#O 05fallOtimeOforOanalysis Afterpulsing •O&elayedOavalanchesOcorre• 05latedOtoOtheOprimaryOpulse •ORmportantOnuisanceOchargeO 05contribution PDE •OIfficiencyOtoOdetectOsingleO 05photons •OUngle•)Owavelength•OandO 05biasOvoltage•dependent •OnIX;OrequirementsOmet nEXOgenergygresolution •O&ependsOonO+&IO#OphotonO 05transportOefficiencyO0+TI5 •O+lotOshowsOcaseOofO+TI%?T-OOOOO 050electronicOnoiseOneglected5 •OzesolutionOgoalOachievable SiPMgHVgrobustness •OSi+=sOwillObeOexposedOtoOexternalOelectricO 05fieldsOupOtoO-? kVjcmOinOnIX;OaccordingOtoO 05H;=S;°Osimulations •O&etectorsOfoundOtoObeOoperationalOinOhighO 05electricOfieldsOatOcryogenicOtemperatures •OGasicOparametersOunaffected–O/oOdischarge •O/oOdamageO•OevenOonOaOmicroscopicOlevel Measuringgprocedureg@gECAP Measuringgprocedureg@gStanford •OzecordO+=TOandOSi+=OpulsesOfromO-6-Hf •OHalibrationOofOsingleOphotonOresponses •OIxtractOchargeOratioOofOtheOdecayO 05spectrumOpeaks •OTranslateOinto 05absoluteO+&I 05usingOtheO+=T 05referenceOµI •OUccountOfor5cor• 05relatedOnoise [v]OUgostiniOetTOalT)Ov]?6T?-~~[ [-]OIX;•-??•HollT)OarXivqv]?]T?3]?] [1]qOnIX;•HollT)OarXivqv]v?T?6?]6 [-]qOnIX;•HollT)OarXivqv3?6Tvvv2- Wb Wb e e ? 6 v? v6 -? -6 1? ? ?T- ?T2 ?T[ ?T3 v vT- +hoton detection eﬃciency [:] Udditional avalanches within vµs °7 Sv °7 S- ST& S ?T] ?T3 ?T~ v vTv vT- vT1 vT2 ? v - 1 2 6 [ Inergy resolution [:] ;vervoltage [V] °7 Sv °7 S- ST& S ? v - 1 v?? v?v v?- v?1 v?2 prompt crosstalk prompt delayed crosstalk afterpulsesOand darkOnoise 0afterpulsesOand darkOnoise5Osuffering promptOcrosstalk afterpulsesOsuffering promptOcrosstalk afterpulses Hharge [pTeT] Time after trigger [ns] ? v - 1 v?? v?v v?- v?1 v?2 v?? v?v v?- /umber of events v?? v?v v?- v?1 v?2 v?6 v?[ v?] v?? v?v v?- v?1 v?2 v?6 v?[ v?] v?3 v?~ +ulse rate [Qz] Time to next pulse [ns] ]Tv V 2T[ V 1T[ V [kVjcm] I ? 6 v? v6 -? -6 1? 8ain η ?T3 ?T36 ?T~ ?T~6 v vT?6 vTv vTv6 vT- 7GK•z8G 7GK•lowOfield QamamatsuOVUV1 relativeOSi+=O8ain [kVjcm] I ? 6 v? v6 -? -6 1? H/ + η ?T3 ?T36 ?T~ ?T~6 v vT?6 vTv vTv6 vT- 7GK•z8G 7GK•lowOfield QamamatsuOVU	poster
Materials and Methods Sarah K . Morris1†; Oscar A. Pérez-Escobar1,2†; Bente B. Klitgård1; Alexandre Antonelli1,2; Alejandro Zuluaga3; Monica Carlsen4; Eve J. Lucas1; Simon Mayo1; Anna Haigh1; Steven Dodsworth5; Olivier Maurin1; Grace Brewer1; Robyn Cowan1; Ilia J. Leitch1; Felix Forest1; William J. Baker1 The origin and diversification of the hyper-diverse flora in the Chocó biogeographic region Objectives Anthurium obtusilobum Silica-gel dried leaf fragments 13 outgroup 27 Anthurium DNA extraction, shearing, library preparation, pooling, hybridization and sequencing as described in Johnson et al. (2018) with Angiosperm353 bait kit HybPiper v 1.3.1 (with Spathiphyllum kochii reference) skimmed plastid genome data (39 Anthurium) multiple sequence alignment use full genomic alignment to constrain combined alignment for Maximum Likelihood tree Secondary calibration age of Pothoideae13 Petrocardium cerrejonense (55.8 Myr)8 divergence time estimation with BEAST v2.0 geographic occurrence data from GBIF ancestral range estimation comparing biogeographical models with R-package BioGeoBEARS v0.2.1 1Royal Botanic Gardens, Kew. TW9 3AE, London, UK 2Gothenburg Global Biodiversity Centre, Sweden 3Universidad del Valle, Colombia 4Missouri Botanical Garden, USA 5University of Bedfordshire, Luton, UK †these authors contributed equally to this study *corresponding authors: o.perez-escobar@kew.org, s.morris@kew.org Alwyn H. Gentry (Annals of the Missouri Botanical Garden, 1996) Geographic extension of the Chocó biogeographical region in Central and South America12 and its compound geological origin14 Extract loci from genomic alignments that match Sanger sequences from Carlsen & Croat (2013) Angiosperm 353 kit successfully enriched 50-333 nuclear genes (& recovered 93 plastid genes) species-tree coalescence analyses revealed extensive incongruence near the MRCA of Anthurium the timing and origin of the MRCA of Anthurium remains unclear multiple migrations into Chocó: 3 at ~9 Mya from Central America 1 at ~5 Mya from Amazonia multiple recent migrations within 1 My from Central America and northern Andes Were Gentry’s ideas about the mode and tempo of plant evolution into the Chocó correct? Chocoan flora is likely older than Gentry assumed (perhaps late Miocene) migrations occurred after rapid mountain building had begun in the northern Andes allopatric speciation due to Andean uplift unlikely origin of Chocoan flora from Central America and northern Andes is supported migrations split between 9 Mya and < 1 Mya, suggesting a burst of migration after the closure of the CAS and again more recently Gentry believed the habit type, dispersal system and pollination syndrome of the Chocoan flora allowed for rapid speciation of endemics7: shorter generation time of shrubby and herbaceous groups bird and mammal (more localized) dispersal specific pollinator relationships To investigate these biotic factors, we are conducting similar genomic studies of other representative groups, including Blakea (Melastomataceae) and Neotropical orchids14 key geologic events in mid-late Miocene: 1. accretion of the Chocó Block4 2. Northern Andean orogeny9 3. closure of the Central American Seaway (CAS)10 The Chocó Introduction Gentry from available floristic, geological and palynological data in the 80s: Chocoan flora originated in the mid- Pleistocene from Amazonian lineages which migrated around the northern Andes, through southern Central America 6 “the historical accident of the Andean uplift, with the concomitant opportunity for explosive speciation among certain taxa … may largely explain the “excess” plant species diversity of the Neotropics” 5 Test Gentry’s hypothesis with genomic data of Anthurium using phylogeny reconstruction, molecular dating and ancestral area estimation We expect to see: a MRCA for the Anthurium lineage in Amazonia a MRCA of Chocoan clades in the northern Andes and Central America migration into the Chocó in the Pleis	poster
State-independent wind Wind-related features Observing a black hole transient Javier Sánchez-Sierras E-mail: javisansie@gmail.com Instituto de Astrofísica de Canarias Wind-type outflows from the black hole X-ray binary MAXI J1820+070: the near infrared view SOFT HARD X-ray winds (expected) Optical winds Near-infrared winds MAXI J1820+070 is a low-mass X-ray binary (LMXB) with a black hole of ~8M☉located very nearby, at only 3kpc. It was discovered during a bright outburst of the source in 2018, which showed a standard evolution in the Hardness-Intensity Diagram (see image below), passing through the main accretion states: hard and soft. THE SPECTRA We obtained 8 spectra using VLT/X-shooter, a spectrograph with a wide spectral range from optical to near-infrared (3000 Å – 24750 Å). These observations cover the different accretion states (soft, red; intermediate, green; hard, blue). Optical winds have been observed during the bright-hard state, which is consistent with previous studies in other LMXBs, such as V404Cyg, V4641Sgr or GRS 1716-249. The optical winds discovered during the hard state were observed in some optical lines, such as Ha or HeI-5876Å. The wind-related features observed include P-Cygni profiles and broad emission line wings, and they showed velocities of 1200-1800 km/s. NEAR-INFRARED SPECTRAL RANGE We analysed several near-infrared lines during the hard state and found wind-related features such as blue- shifted absorptions and broad emission line wings (see image above). These features showed similar kinetic properties to the optical ones. During the soft state, these wind features disappear in optical lines but remain visible in the near-infrared spectra. The presence of wind-related features in near-infrared lines during both hard and soft accretion states, with similar kinetic properties to the hard state optical ones, suggests that they are tracing the same wind. This state-independent wind changes its visibility depending on the conditions of the material (i.e. temperature, ionization level, ...). This idea can be seen in the sketch above, which shows the presence of the wind during the 2018 outburst of MAXI J1820+070. This represents one more step to complete the picture of winds in X-ray binary outbursts. Sánchez-Sierras J. 1,2, Muñoz-Darias T. 1,2 1 Instituto de Astrofísica de Canarias (Tenerife, Spain), 2 Universidad de La Laguna (Tenerife, Spain) Based on paper: Sánchez-Sierras & Muñoz-Darias, 2020, A&A 640 L3	poster
SAW 2024 – Seeing and AcƟng Workshop: FuncƟonal and Neural PerspecƟves Poster Session 1 — September 27, Friday 1 – Visually guided acƟons survive bilateral lesions of the occipitotemporal cortex: evidence from behavioural and tractography Authors: Ana C. Torres Cresto, Marine Keime, Alessandro Vinciarelli, Melvyn A Goodale, Jody C. Culham, Cassandra Sampaio-BapƟsta, Monika Harvey 2 – EvoluƟonary approaches for audio-visual associaƟons Authors: Ana Rodrigues, Amílcar Cardoso, Penousal Machado 3 – Seeing speech: Probing the cerebral mechanisms of Cued Speech percepƟon Authors: Annahita Sarré, Laurent Cohen 4 – Using ultra-high resoluƟon MRI to uncover the underlying microstructural mechanisms of structural plasƟcity in blind humans Authors: Anna-Lena Stroh, Daniel Haenelt, Luke J. Edwards, Fakhereh Movahedian AƩar, Kerrin J. Pine, Robert Trampel, Marcin Szwed, Nikolaus Weiskopf 5 – DiﬀerenƟal modulaƟon of serial dependence by acƟon percepƟon integraƟon in auƟsm spectrum traits in a dynamic VR task Authors: Antonella Pomè, Michael Wiesing, Rebecca Süther, Eckart Zimmermann 6 – Does Observing Bodily Movement Contribute to Developing Goal Comprehension? Authors: Ben-Ami Shlomit, Verma Dhun, Lall Naviya, Ganesh Suma Ralekar Chetan, Gilad- Gutnick Sharon, Sinha Pawan 7 – Touch localizaƟon aŌer nerve repair: Longitudinal measures reveal high individual variability Authors: Benjamin Govier, MarƟn Weber, Andrew Marshall, Obi Onyekwelu, Louise Booth, Edwin Jesudason, Vivien Lees, Ken Valyear 8 – FuncƟonal organisaƟon of sensorimotor regions in people with congenital facial paralysis (Moebius Syndrome) Authors: Ceren BaƩal, Emmanuelle Bellot, Benoit Herman, Iqra Shahzad, Moritz Wurm, Olivier Collignon, Gilles Vannuscorps 9 – Can the dimensionality crossing phenomenon partly explain the large sex diﬀerence in the mental rotaƟon test? Authors: Daniela E. Aguilar Ramirez, Stephanie Chu, Claudia L. Gonzalez 10 – Reach adjustment and target selecƟon begin within 80ms Authors: David Y. Mekhaiel, Melvyn A. Goodale, Brian D. Corneil 11 – Comparing object topography in visual cortex and arƟﬁcial neural networks Authors: Davide CorƟnovis, Bracci Stefania 12 – Reward as a facet of word meaning Authors: Doina-Irina Giurgea, Penny M. Pexman, Richard J. Binney 13 – Distributed high-level processing supports the emoƟonal assessment of complex social scenes (human brain and AI) Authors: Elahe Yargholi, Laurent Mertens, Joost Vennekens, Jan Van den Stock, Hans Op de Beeck 14 – Changes in connecƟvity between ‘higher order’ perceptual areas in apraxia aŌer stroke Authors: Elisabeth Rounis Zuo Zhang, Ajay Halai, Gloria Pizzamiglio, MaƩ Lambon Ralph 15 – Localising touch on the hand: Revealing systemaƟc variaƟons in performance and context-dependent direcƟonal biases. Authors: Elsie Harvey Pearce, Ronan Timircan, MarƟn Weber, Kenneth Valyear 16 – InvesƟgaƟng the funcƟons underlying short-term memory conjuncƟve binding through the study of aphantasia Authors: Emma Delhaye, Pauline Fritz, CharloƩe MarƟal, ChrisƟne BasƟn 17 – TesƟng humans and machines on the animate-inanimate disƟncƟon for ambiguous visual objects Authors: Farzad Rostami-Ghahfarokhi, Céline Spriet, Hans Op De Beeck, Jean-Remy Hochmann, Liuba Papeo 18 – AƩenƟon to AcƟons Authors: Federica Danaj, Lena Gessele, Jens Schwarzbach, Paul Downing, Angelika Lingnau 19 – ConnecƟng the dots: similar visual reading acquisiƟon for Braille or line juncƟons Authors: Filippo Cerpelloni, Olivier Collignon, Hans Op de Beeck 20 – ReweighƟng of Visual Depth Cues through Dynamic InteracƟon with ConﬂicƟng SƟmuli Authors: Francesca Peveri, Andrea Canessa, Silvio P. SabaƟni 21 – Does unisensory object categorisaƟon improve following mulƟsensory category training? Authors: Grace A. Gabriel, Fiona N. Newell 22 – InteracƟons of Visual and Motor PlasƟcity in Adults Authors: Izel D. Sari, Claudia Lunghi 23 – A specialized mental resource for intuiƟve physics Authors: Jason Fischer, Alex Mitko 24 – Ultrafast RS fMRI unveils	poster
Health-related quality of life of people attending screening for diabetic retinopathy within a trial setting CJ Sampson,1† M James,1 D Van Eker,2 D Szmyt,2 SP Harding3 †chris.sampson@nottingham.ac.uk 1University of Nottingham \| 2Royal Liverpool University Hospital \| 3University of Liverpool Introduction Background • DR associated with lower health-related quality of life (HRQoL) • Economic evaluations tend to base outcomes on visual acuity. Aims • Estimate generic HRQoL for a cross-section of attenders within the UK screening programme • Inform calculation of quality-adjusted life years (QALYs) for model-based economic evaluation. Methods: the sample ▶874 people from 7 screening centres in Liverpool, UK ▶Baseline trial data from the ISDR study ▶Matched screening outcome data R0 No retinopathy R1 Background retinopathy (in at least one eye) Methods: outcome measures ▶Two widely-used generic descriptors of HRQoL. ▶Both can be used to calculate QALYs. ▶Together provide 5 ways to measure HRQoL. EQ-5D-5L Dimensions 5 dimensions reported from 1 (no problems) to 5 (extreme problems) Index score Weighted score based on health state preferences elicited from the UK general public, used to calculate QALYs EQ-VAS A visual analogue scale from 0 (“The worst health you can imagine”) to 100 (“The best health you can imagine”) HUI3 Dimensions 8 dimensions (including ‘vision’) scored from 1 (no problems) to 5 or 6 (severe functional limitations) Index score Multi-attribute utility function, to calculate QALYs Results: full sample ▶840 (96%) fully completed EQ-5D-5L ▶738 (84%) fully completed HUI3 ▶Mean EQ-5D-5L index score was 0.777 ▶Mean HUI3 index score was 0.707 Table: EQ-5D-5L: distribution of responses 1 2 3 4 5 Mobility 52% 15% 17% 15% 0% Self-care 76% 10% 10% 4% 1% Usual activities 57% 15% 15% 10% 3% Pain/discomfort 43% 20% 20% 14% 4% Anxiety/depression 67% 14% 12% 5% 1% Table: HUI3: distribution of responses 1 2 3 4 5 6 Vision 31% 63% 3% 2% 2% 1% Hearing 78% 11% 7% 3% 1% 0% Speech 93% 4% 2% 0% 0% — Ambulation 63% 18% 11% 5% 2% 0% Dexterity 81% 14% 2% 2% 1% 0% Emotion 66% 21% 9% 3% 1% — Cognition 68% 8% 18% 4% 2% 0% Pain 40% 26% 15% 12% 7% — ▶Dimensions with ≥20% of responses are highlighted Results: R1 vs R0 ▶R1 screening outcome associated with lower HRQoL on average than R0 EQ-5D-5L 0.762 vs 0.776 HUI3 0.660 vs 0.713 (p=0.03) EQ-VAS: How do EASDec delegates compare? ▶The left side of the scale shows the distribution in our sample. ▶Place a sticker on the right according to how good or bad your health is TODAY. The best health you can imagine 100 0 The worst health you can imagine Discussion ▶HUI3 recognised as being more sensitive to visual impairment, but may require trade-off with data quality • Lower mean HUI3 index score may reflect inclusion of sensory domains ▶Economic modelling studies that treat R1 and R0 as homogeneous may give biased results ▶We cannot determine whether the difference in HRQoL between R1 and R0 is because of retinopathy level Conclusions ▶DR screening attendees have an impaired HRQoL compared with the general population ▶People with background retinopathy have lower health-related quality of life than people with no retinopathy • Statistically significant difference of 0.053 in mean HUI3 index score ▶HUI3 is associated with poorer completion rates • Greatest missingness on ‘vision’ domain ▶www.isdrproject.co.uk ▶Twitter @ISDRstudy Download this poster DOI: 10.6084/m9.figshare.3443705 This poster presents independent research funded by the NIHR under the Programme Grants for Applied Research programme (RP-PG-1210-12016). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Heath.	poster
Altered Physiological Conditions Lead To Antibiotic Persistence In Vibrio Cholerae. Shridhar Paranjape*, Shashidhar R. Bhabha Atomic Research Centre, Mumbai, India. shridharsonda@gmail.com Introduction The physiological heterogeneity of a bacterial population is a complex phenomenon. The asymmetric cell division and asynchronous metabolic activities result in the population with age gradients. The persister cells are the transiently dormant cells which survive prolonged exposure to bactericidal antibiotics. We hypothesized that the changes in nutrient levels, which are common in the environment, can cause significant changes in tolerance to antibiotics. Here, an attempt has been made to disturb the cell physiology using different strategies to alter the antibiotic persistence. Methods • Antibiotics used: Ciprofloxacin, Ampicillin, Carbinicillin, Kanamycin, Erythromycin, Gentamycin and Chloramphenicol. Data 1. Mulcahy LR, Burns JL, Lory S, Lewis K. 2010 Dec;192(23):6191–9. 2. Harms A, Maisonneuve E, Gerdes K. Science. 2016 Dec 16;354(6318). pii: aaf4268. 3. Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K. 2015 May 26;AAC.00864-15. 4. Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. 2004 Sep 10;305(5690):1622– 5. 5. Fauvart, Maarten & De Groote, Valerie & Michiels, Jan. (2011). 60. 699-709. 10.1099/jmm.0.030932-0. Results 1. The V. cholerae forms persister subpopulations , when challenged with ampicillin and ciprofloxacin. (Fig. 1) 2. The persistence varies with the media type, in the order of decreasing persistence: TSB > LB > M9 > APW. (Table 1) 3. The reduced respiration is key to successful persistence. (Table 2) 4. The V. cholerae was sensitive to inhibition of protein synthesis with no persistence formation. (Table 3) • The present study reveals the complex responses of cell population under antibiotic treatment. • This research could be the beginning of phylogenic clad specific studies of persister cell formation with respect to cell physiology. • The persistence may represent a unique physiological state amongst the various physiological states in a bacterial population. – Single cell based studies may reveal more about the molecular mechanisms underlying persister physiological states. References Fig. 1.Effect of different antibiotics on exponential culture of V. cholerae Table 1. Persistence as a function of media type and nutrient. Table 2. Persistence as a function of respiration Table 3. Persistence as a function of protein synthesis Discussion Fauvart et al.(2011) 0 1 2 3 4 5 6 7 8 9 10 0 2 4 6 8 10 Log CFU ml-1 Time (hours) V. cholerae Ciprofloxacin Kanamycin Ampicillin Persister frequency Media V. Cholerae E. coli Luria Bertani broth 0.1 0.1 Tryptone soya broth 10 0.1 Alkaline peptone water 0.001 NA M9 minimal media 0.01 0.01 Antibiotic V. cholerae E. coli Aerobic An- aerobic ATP - uncoupler Aerobic An- aerobic ATP- uncoupler Ampicillin 1 10 10 0.01 100 100 Ciprofloxacin 0.1 100 10 0.01 10 100 Kanamycin 0 0.01 0 0.1 10 10 Antibiotic V. cholerae E. coli Kanamycin 0 0.1 Chloramphenicol 0 1.0 Erythromycin 0 0.1 Gentamycin 0 0.1	poster
the problem methodology findings on the one hand 1st possible consequence To assess the evaluation process of professional doctorate proposals, three types of analysis were performed: Even though they were not clear before, CAPES had some expectations from proposals. From the evaluation reports of the 105 projects which were not approved, we see examples of such unfulﬁlled expectations: According to CAPES, without previously establishing the criteria and indicators for the accreditation of professional doctorates, they expected: In spite of the lack of pre-established criteria and indicators for the accreditation process, this research showed that CAPES’ evaluation was well conducted and that expectations for the approval of PrD courses are consistent throughout ﬁelds. Expectations Reality on the other hand • Without criteria or indicators for PrD, proposals were: • Too conservative and did not innovate from this “freedom”; • Inspired by academic doctorates (without the required professional nature) or professional master’s (not advanced enough). • Without ground-breaking proposals at hand, the accreditation process could only focus on the viability of the proposed courses, resulting in low approval rates. • The lack of pre-established criteria and indicators did not mean a lack of expectations. Several proposals were weakened because of that. André Brasil a.l.brasil@cwts.leidenuniv.nl Centre for Science and Technology Studies Leiden University, The Netherlands September, 2019 Accreditation of Graduate Courses in Brazil Analysing the Evaluation of the First Proposals of Professional Doctorates in the Country http://bit.ly/2Z6KqJp Approval rates are strikingly different between academic and professional proposals, with fewer accredited courses in the second modality. Proposals Approved Not approved 43.9% 60.0% 77.8% 78.2% Academic Doctorate (PhD) Academic Master’s Professional Doctorate (PrD) Professional Master’s 56,1% 40.0% 22.2% 21.8% Graduate education is responsible for over 80% of S&T research in Brazil Professional Master’s were authorised in 1998 and Doctorates in 2017/2018 135 professional doctorate (PrD) proposals were submitted in the ﬁrst evaluation cycle There are over 6500 graduate courses in the country today Course accreditation is compulsory, conducted by a federal agency (CAPES) No criteria or indicators were stablished before submissions Could an evaluation process without previously defined criteria and indicators work? NOT WITHOUT CONSEQUENCES! http://bit.ly/2M9awpk Get the full paper, this poster, and more at: Regulations and guideline documents related to the accreditation of graduate courses were investigated. Documental The evaluation results of 1404 accreditation proposals were analysed across distinct ﬁelds, levels and modalities. Statistical The reports on the assessment of the 135 professional doctorate proposals were individually analysed in order to identify the existence of coherent criteria and indicators. Qualitative 1 2 3 4 5 6 UNRESTRICTED Proponents would not be limited by pre-established concepts of what a professional doctorate should be. INNOVATION They would innovate, designing ground-breaking graduate programs, which could inspire evaluators. INSPIRATION Evaluation committees would build criteria and indicators based on proposals and previous experience. GUIDELINES The evaluation effort would lead to proper guideline documents to support future submissions. 1 2 3 4 INSTITUTIONAL SUPPORT Expected: projects should include evidence of integration with productive sector. Reality: most projects were successful in that, but some failed to show these partnerships. 73% positive PROPOSAL Expected: projects should have an applied science design at a doctoral level. Reality: most proposals were either too academic or were closer to a master’s level. FACULTY (Profile) Expected: faculty could include experienced professionals from the productive sector. Reality: faculty proﬁle was almost exclusively	poster
Cuscuta campestris Cuscută mare Familia Convolvulaceae, Clasa Magnoliopsida Plantă erbacee anuală, parazită, lipsită de cloroﬁlă, fără frunze, cu tulpini volubile, foarte ramiﬁcate, galbene-portocalii, ce formează prin împletire și răsucire plase laxe ce se întind ca o pânză pe suprafețe de mai mulți metri pătrați. Florile sunt nemirositoare, dispuse câte 10-30 într-un glomerul. Corolă campanulată, cu lobii triunghiulari, acuți. Fructul este capsulă globuloasă, ușor turtită, cu 2-4 semințe brune, ovoidale, cu suprafața neregulată. Foto credit: https://www.invasive.org/search/action.cfm?q=cuscuta+campestris Flori Fruct 1 Semințe	poster
SITool (v1.0) An evaluation tool for large-scale sea ice model simulation Xia Lin, François Massonnet, Thierry Fichefet, and Martin Vancoppenolle 1) Absolute errors at each grid cell (1980-2007) Mean: ->monthly mean over 12 months (Meandiff) Interannual variability/trend: monthly anomalies -> standard deviation (SDdiff)/linear regression (Trenddiff) 2) Average spatially weighted by grid cell areas 3) Scaled by typical errors (absolute difference between two observations) Meandiff = ∑!"# !"#$ ∑&"# &"' ()* !,& ,(#* !,& ×.& ∑&"# &"' .& × #! ∑!"# !"#$ #! (1) SDdiff = ∑&"# &"' $%(')&(')* & )($%('#&('#* & ) ×& ∑&"# &"' & (2) Trenddiff = ∑!"# !"$ "#$%&((%!)(%& ! ))"#$%&((#!)(#& ! ) ×,! ∑!"# !"$ ,! (3) 𝑛(months); 𝑖(grid cells); 𝐶/0, 𝐶10/ 𝐶/, 𝐶1(two monthly mean/monthly ice concentration); A (grid cell area); D (days in each month). Sea ice plays a fundamental role in the polar environment, by influencing air–ice and ice–sea exchange, atmospheric and oceanic processes, and climate change. Large inter-model spread exists in the performance of sea ice simulations. Systematic projections and evaluations on sea ice simulations are needed. Want to quantify the bias in sea ice simulations? Want to track performance across different model versions? Try SITool released on the GitHub (open-access): https://github.com/XiaLinUCL/Sea-Ice-Evaluation-Tool A performance metrics and diagnostics tool developed to evaluate the skill of Arctic and Antarctic model reconstructions of sea ice concentration, extent, edge location, drift, thickness, and snow depth. 1 The concept of the SITool 3 Application to CMIP6 OMIP 2 The methods in SITool Find more information on the sea ice edge location, drift, thickness and snow depth in Lin et al. (2021). Xia Lin, François Massonnet, Thierry Fichefet and Martin Vancoppenolle, SITool (v1.0) – a new evaluation tool for large-scale sea ice simulations: application to CMIP6 OMIP. Geosci. Model Dev., 14, 1–24, 2021. SITool provides metrics and diagnostic maps 3.1 Sea ice concentration 3.2 Sea ice extent Any comments/questions? Get in touch! xia.lin@uclouvain.be Metrics: Lower values -> better skill 1) Model errors >> observational uncertainty 2) Improved simulations from OMIP1 (CORE-II) to OMIP2 (JRA55-do) 3) Lower skill on the ice concentration variability Ice extent: total area of grid cells with the ice concentration above 15% -negative ice extent biases in the summer reduced in OMIP2 Model mean ice extent monthly anomalies; -large bias reduced under OMIP2 Diagnostic maps: Reduced negative bias of summer Arctic ice concentration in OMIP2	poster
1) Background • Many people struggle to manage indulgences in our current ‘obesogenic’ environment (Kruger et al. 2004) • Results of our previous qualitative study showed that one of the strategies to reduce intake of tempting foods is to plan meals in advance (Gatzemeier et al. under review) • Planned indulgences increase motivation to continue with goal pursuit (e.g. following a diet to lose weight) (Coelho do Vale et al. 2016) • High restrained eating is associated with lower food intake (Olea López et al. 2016) Jennifer Gatzemeier, Menna Price, Laura Wilkinson, Michelle Lee Department of Psychology, Swansea University, UK. Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Rigid and flexible restraint moderates a relationship between a future eating prime and food intake Coelho do Vale, R., et al. (2016). "The benefits of behaving badly on occasion: Successful regulation by planned hedonic deviations." Journal of Consumer Psychology 26(1): 17-28. Gatzemeier, J., et al. (2018). “Understanding everyday strategies used to manage indulgent food consumption: a mixed-methods design.” Manuscript submitted for publication. Kruger, J., et al. (2004). "Attempting to lose weight: Specific practices among U.S. adults." American Journal of Preventive Medicine 26(5): 402-406. Olea López, A. L. and L. Johnson (2016). "Associations between Restrained Eating and the Size and Frequency of Overall Intake, Meal, Snack and Drink Occasions in the UK Adult National Diet and Nutrition Survey." PLoS One 11(5): e0156320. Van Strien, T., et al. (1986). "The Dutch Eating Behavior Questionnaire (DEBQ) for Assessment of Restrained Emotional, and External Eating Behavior." International Journal of Eating Disorders 5(2): 295-315. Westenhoefer, J., et al. (1999). "Validation of the flexible and rigid control dimensions of dietary restraint." Int J Eat Disord 26(1): 53-64. 3) Methods 3) Methods • Procedure a) Priming: Intervention: writing down near future eating plans Control: writing down near future non-eating plans (e.g. going to the cinema) b) Presentation of taste test: c) Questionnaires: DEBQ (Van Strien, Frijters et al. 1986) Rigid and flexible restraint (Westenhoefer, Stunkard et al. 1999) Question about trait tendency to plan indulgences • Analysis: Moderation analysis with SPSS PROCESS macro • Registered at OSF (https://osf.io/pydvz) 5) Conclusions 5) Conclusions • Flexible and rigid restraint is indeed moderating the association between condition and intake: The intervention condition had a significantly higher consumption compared to the control condition, but only in low rigid and flexible restraint • For low restrained eaters thinking about future eating plans might have enhanced attention to the snacks and therefore increased wanting • High restraint eaters exert a high level of cognitive control to maintain restraint. This might have led to an insensitivity to the priming • Further research is needed to understand the underlying mechanism of the observed interactions and the difference between low and high restrained eaters 2) Research Questions 2) Research Questions • We hypothesis that the trait tendencies to plan indulgences moderate the association between a future eating prime and food intake. Participants with the trait tendencies to plan indulgences consume less after a future eating prime • We are interested if restraint is moderating the relationship between the priming and intake. Contact: Jennifer Gatzemeier jennifer.gatzemeier@swansea.ac.uk Department of Psychology, Swansea University, Singleton Park, Swansea, SA2 8PP, UK Tel: +44 (0) 1792 295279 Swansea Nutrition, Appetite and Cognition group a) Priming b) Taste test c) Questionnaires 1. Minstrels (Mars, UK) 2. Bitsa Wispa (Cadbury, Mondelez, Birmingham, UK) 3. Haribo Star Mix (HARIBO Dunhills, Pontefract, UK) 4. Pringles Original (Wimble Manufacturing Belgium, Mechelen, Belgium) 5. Salted Popcorn (Tesco Stores Ltd., Cheshunt, U	poster
Reactor Neutrino Anomalies and Possible Solutions Yu-Feng Li* Institute of High Energy Physics, Beijing, China *corresponding author: liyufeng@ihep.ac.cn Reactor neutrinos (electron antineutrinos) are produced from beta decays of the neutron-rich fission products, and are detected via the inverse beta decay (IBD) process. Reactor experiments have shown anomalous results for both IBD rate (left plot) and spectrum (right plot) measurements Reactor rate anomaly: measured IBD yields are smaller than model predictions by around 6%. Reactor spectrum anomaly: there is a bump at around 5 MeV when comparing the measured and predicted spectra. How to solve these reactor anomalies is an intensively discussed topic in nuclear and particle physics community. 1. Reactor neutrino anomalies 3. Ab initial method Using the reactor rates data and fuel evolution data: 2. Data-driven method Reactor rates tend to favor equal suppression of the 235U and 239Pu fluxes (oscillation), while (DYB & RENO) fuel evolution data favor the suppression of 235U. Regarding all hybrid hypotheses: a) a deficit for the 235U flux is always obtained; b) oscillation-including hypothesis is favored over the oscillation-excluding one: moderately at 1-2σ 5. Conversion method Giunti et al., JHEP 10 (2017) 143 4. Beta decay at KATRIN 6. Conclusion Reactor rate/spectrum anomalies are interesting topics in particle and nuclear physics, and awaiting satisfactory solutions. Data-driven method always favors a suppression of the 235U flux, while KATRIN can provide independent tests. Both the ab initial and conversion calculations need to be improved in many aspects (database, fission yield and single spectrum, etc.). Accurate reactor rate and spectrum predictions are important for future reactor experiments (i.e., JUNO). Giunti et al., Phys. Rev.D 99 (2019) 073005 Ab initial model for the reactor neutrino flux: summation of each beta decay branches using the nuclear database for the fission and decay information Possible problems: the nuclear database (e.g., pandemonium effect), fission yield, single beta decay spectrum, etc. We discuss the effects of the single beta decay spectrum by using a fully numerical calculation of lepton wave functions, compared to previous ones using the famous Fermi function. Fang, et al., arXiv: 2001.01689 ENDF VIII.0, for fission yield data, and ENSDF for the decay data. 2% and 4% deviations for the neutrino and electron spectra. Beta decay is a model-independent way to probe the absolute neutrino masses. KATRIN published its first data in 2019, with a limit on the effective neutrino mass as mν< 1.1 eV (95% C.L.). We test the reactor rate anomaly using the beta decay data at KATRIN by assuming the 3+1 active-sterile mixing. KATRIN improves the exclusion of the large-Δm2 41 solution of the Huber-Muller reactor rate anomaly. RSR: the reactor spectra ratio data test a large part of the small-Δm2 41 region. Tritium: KATRIN + Mainz + Troitsk RSR and Tritium limits are complementary, and rule out most of the parameter space. Giunti et al., JHEP 05 (2020) 061 Conversion model for the reactor neutrino flux: using dozens of virtual beta decay branches to fit the aggregate electron spectra of 235U, 239Pu, and 241Pu at ILL. We propose a new realization of the conversion calculation by including the contribution of forbidden decay branches. Using data of ILL U235 beta spectrum Li, et. al., Phys. Rev. D 100 (2019), 053005 7. Reference [1] G. Mention et al., Phys. Rev. D 83 (2011) 073006. [2] T.A. Mueller et al., Phys. Rev. C 832011) 054615. [3] P. Huber, Phys. Rev. C 84 (2011) 024617. [4] KATRIN, Phys. Rev. Lett. 123 (2019) 221802. [5] C. Giunti et al., Phys. Rev. D 99 (2019) 073005. [6] Y.F. Li, D. Zhang, Phys. Rev. D 100 (2019) 053005. [7] D.L. Fang et al., arXiv: 2001.01689. [8] C. Giunti et al., JHEP 05 (2020) 061.	poster
LATEX TikZposter ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in ANALYTICAL HALO MODEL OF GALACTIC CONFORMITY Isha Pahwa and Aseem Paranjape Inter-University Centre for Astronomy and Astrophysics, Pune University Campus-Ganeshkhind, Pune - 411007 ipahwa@iucaa.in Galactic Conformity is the observation that satellite galaxies in groups whose central galaxy is quenched (or red) are preferentially quenched, even when the groups are restricted to reside in dark matter halos of the same mass. We develop a model to include the effects of ‘Galactic conformity’ within halo occupation distribution (HOD) framework. This effect has been modelled via the correlation of galaxy colors in a group with the concentration of the common parent dark matter halo. Standard HOD Framework • fcen(> L\|m) - The fraction of m-halos (i.e., halos with masses in the range (m, m + dm)) that have a central galaxy brighter than the luminosity threshold L. • Nsat(> L\|m) - The number of satellites brighter than L in each m-halo with a central brighter than L (assumed to be Poisson distributed with mean). fcen(> L\|m) = 1 2 1 + erf log(m/Mmin) σlog m , Nsat(> L\|m) = m −M0 M1 α , [Zehavi et al 2011] with {Mmin, σlog m, α, M1, M0} being functions of the threshold L. We deﬁne the following quantities that are ﬁxed by the HOD: Nsat(> L\|m) ≡fcen(> L\|m)¯Nsat(> L\|m) ; fcen(L\|m) ≡−∂fcen(> L\|m)/∂L , Nsat(Lm) ≡−∂Nsat(> L\|m)/∂L ; ¯Nsat(L\|m) ≡Nsat(L\|m)/fcen(> L\|m) . Color-selcted HOD •Given p(red\|Mr) = 0.423 −0.175 (Mr + 19.5) and [Paranjape et al 2015] p(red\|sat, Mr) = 1.0 −0.33 1 + tanh Mr+20.25 2.1 , one can calculate p(red\|cen) from equation p(red\|L) = p(red\|cen, L) ¯p(cen\|L) + p(red\|sat, L) ¯p(sat\|L) , where ¯p(sat\|L) = R dm n(m) Nsat(L\|m) R dm n(m) [fcen(L\|m) + Nsat(L\|m)] • The HOD split by galaxy colour - frcen(L\|m) ≡p(red\|cen, L)fcen(L\|m) , Nrsat(L\|m) ≡p(red\|sat, L)Nsat(L\|m) , ¯Nrsat(L\|m) ≡Nrsat(L\|m)/fcen(> L\|m) = p(red\|sat, L)¯Nsat(L\|m) . frcen(L\|m)dL is the differential fraction of m-halos with red L-centrals and ¯Nrsat(L\|m)dL is the mean differential number of red L-satellites in m-halos with centrals (of any colour) brighter than L. Red fractions as a function of luminosity −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 red fraction satellites all centrals psat HOD with galactic conformity • We introduce conformity between the central and satellite colors in a group using the model of Paranjape et al 2015 which correlates the red fraction of a given galaxy type with the parent halo concentration, i.e., a concentration-dependence of the red fraction of satel- lites/centrals at ﬁxed luminosity and halo mass by making galaxies in high (low) concentration halos preferentially red (blue). • Given the fact that distribution of halo concentration c at ﬁxed halo mass is approximately Lognormal with mean ¯c(m) ≡e⟨ln c\|m ⟩and logarithmic scatter σln c, we deﬁne s ≡ln(c/¯c)/σln c . The distribution of s is approximately a standard Gaussian (zero mean and unit variance), independent of halo mass. The conditional red fraction now depends on the parent halo concentration and is given as p(red\|sat/cen, s) = (1 −ρ) p(red\|sat/cen) + ρ Θ(s −sr,sat/cen) , where sr,sat/cen gives the dividing line between high and low concentrations in each case as sr,sat/cen = √ 2 erfc−1 [2 p(red\|sat/cen)] . • “group quenching efﬁciency", ρ ∈[0, 1]. • The color selected HOD with conformity - frcen(L\|m, s) ≡p(red\|cen, s)fcen(L\|m) , Nrsat(L\|m, s) ≡p(red\|sat, s)Nsat(L\|m) and ¯Nrsat(L\|m, s) ≡Nrsat(L\|m, s)/fcen(> L\|m) = p(red\|sat, s)¯Nsat(L\|m) . 1-halo conformity • Difference in the red fractions of satellites with red and blue centrals of similar halo mass represented by red and blue colors. −22.0 −21.5 −21.0 −20.5 −20.0 −19.5 −19.0 Mr 0.0 0.2 0.4 0.6 0.8 1.0 satellite red fraction ½ =0:01 ½ =0:65 ½ =0:90 Correlation funct	poster
A Key Actor in EMI METU English Proficiency Exam: Design, Implementation & Validation Aim The School of Foreign Languages (SFL) initiated a Program Evaluation and Renewal study to investigate the effectiveness of the English Language education curricula at its two departments based on a large scale needs analysis of all relevant stakeholders which involved the evaluation and validation of METU English Proficiency Exam, integral to EMI at METU. Design This research was designed as a mixed methods study. Our approach towards the qualitative / quantitative dilemma was pragmatic. Pragmatism views these two methods as compatible (Howe, 1988, in Teddlie & Tashakkori, 2009), and therefore finds it productive to combine these methods to study phenomena especially in social sciences. Hence, the pragmatic paradigm was the framework of this study. Needs Analysis Data Analysis English Proficiency Examination EPE Revisited- OPERATIONS Design Identifying Target Language Use tasks, task characteristics, theoretical constructs Operationalization Developing test task specifications & test blueprint Administration Alpha & Beta testing Piloting Field-testing Final revision First official version of new EPE Results: Communicative Needs of EMI students Benchmarking, Piloting & External Validity To validate EPE, an experimental pretest-posttest design (N=211) was used to compare EPE scores with an international standardized test, TOEFL IBT, a gatekeeper in many EMI universities. There was a significant positive correlation between EPE and the pretest (r = 0,89, n = 102, p = 0.070); between the two versions of the TOEFL IBT (r = 0,89, n = 102, p = 0.00); and between EPE and the posttest (r = 0.85, n = 115, p = 0.044). EPE cut scores were based on this study. Listening: Field, 2012 Reading: Urqhart & Weir, !998; Khalifa & Weir, 2009 Writing: Shaw & Weir, 2008 Reliability & Internal Validity Predictive Validity & Stakeholder Perception Stakeholders Qualitative / Quantitative Instr. 2612 DBE Ss Surveys / Focus- group interviews 2205 MLD Ss Surveys / Focus- group interviews 133 SFL Instructors Surveys / Interviews 66 Faculty Members Interviews 40 Graduates in 19 Firms Interviews 14 Employers in 12 Firms Interviews Document Analysis of student essays, exams, lab reports from all faculties Communicative Activity Required Skill Listening -listening in-class -assigned listening Very deep attention understanding instructions Medium to deep attention following lectures /discussions Reading -background reading -intensive reading search reading reading longer texts careful reading understanding instructions analytical/critical reading interpreting visuals Writing -writing in -class -assigned writing note-taking writing responses to exam projects, reports, papers fluency & coherence Speaking -spontaneous speech -planned speech communicating with instructors asking & answering Q’s delivering presentations fluency in speech Grammar & Vocabulary basic structures - wide range academic lexis • For quantitative data, descriptive and inferential statistics were employed. Depending on the results of tests of normality, either ANOVA/ t-Test or Kruskall- Wallis and Mann-Whitney U tests were used. • As for qualitative data, the recordings of interviews were analyzed by MaxQDA 11. Miles and Hubermann Qualitative Data Analysis Framework was used (1994). Theoretical Framework of Test Design Sociocognitive Framework, Weir, 2005 The relationship between, TOEFL Pre-and Po EPEsttests Reliability: Cronbach’s alpha, which measures the internal consistency of a group of items was found to be (α= .81). This alpha coefficient is high (≥70 ) in terms of testing. Item Discrimination: The Rpbi mean for the MC items was found to be Rpbi .33, meaning that the exam discriminated well between higher and lower proficiency levels. Items with Rpbi in the .30 - .49 range are considered strong discriminators. Item difficulty: P values for the scored items show a desired distribution of the P (.4	poster
Figura 1. Intervalos para la Varianza aditiva estimada, para los grupos de años. Figura 2. Intervalos para la Heredabilidad estimada, para los grupos de años. 0.0021 0.0060 0.0054 0.0113 0.0000 0.0050 0.0100 0.0150 0 1 2 3 Grupos Va Ln 0.09 0.25 0.16 0.31 0.00 0.10 0.20 0.30 0.40 0 1 2 3 Grupos Heredabilidad Ln Figura 3. Intervalos para la Varianza aditiva estimada, para los grupos de años. Datos en Ln. Figura 4. Intervalos para la Heredabilidad estimada, para los grupos de años. Datos en Ln. Cva Cva Ln Grupo 1 0.055 0.023 Grupo 2 0.080 0.036 Cuadro 1. Coeficientes de variación aditivos para cada uno de los grupos de años, con datos originales y en LN. Evolución de la Variabilidad Genética para peso a edad comercial en una población seleccionada de camarón blanco del Pacífico [Penaeus (Litopenaeus) vannamei]. Cala N¹*, Montaldo HH¹, Castillo-Juárez H², Campos-Montes GR², Ruiz-López FJ³. Universidad Nacional Autónoma de México¹, Universidad Autónoma Metropolitana- Xochimilco², Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, INIFAP³. necamo4@comunidad.unam.mx Introducción En una población de tamaño efectivo limitado bajo selección, se pueden producir cambios en las varianzas genéticas y ambientales a través de las generaciones, que pueden reflejarse en cambios en la variabilidad genética. Estos cambios manifiestan una disminución en la variación genética a través de las generaciones para la población en selección. Objetivo Estimar cambios los componentes de variabilidad genética y ambiental para P130 en 8 generaciones de una población núcleo de camarón blanco del Pacífico bajo selección. Material y Métodos Se usaron datos de ocho generaciones (2003-2010) de una población Mexicana de camarón blanco del Pacifico seleccionada para peso a los 130 días, con su respectivo pedigrí. Se analizaron 123,561 registros, procedentes de la progenie de 1043 madres y 746 padres. La estructura es por familias, provenientes de apareamientos de un macho con dos hembras mediante inseminación artificial. Se utilizó un modelo lineal mixto en ASReml. Los efectos fijos fueron año-estanque-sexo y los efectos lineal y cuadrático de la edad a la cosecha como covariables. Los efectos aleatorios, el efecto genético aditivo, el efecto de ambiente común de familia de hermanos y el error. En el modelo se consideraron varianzas heterogéneas por generación (año). Resultados y Discusión Los parámetros usados para evaluar los cambios fueron la heredabilidad “ ( )”, la varianza aditiva “ ” y el coeficiente de variación aditivo “ (√ ̂)”. Se estimaron las tendencias con las ecuaciones de regresión lineal y polinomiales de segundo y tercer orden para , y . Los resultados para la regresión lineal muestran una tendencia negativa P < 0.05, sin embargo el coeficiente de variación señala una tendencia positiva P < 0.05, lo que es contradictorio. También se realizaron análisis similares usando el logaritmo natural de P130. Posteriormente se dividió la base en dos grupos de años, uno del 2003 al 2006 y otro del 2007 al 2010, intentando buscar una tendencia en los estimados, se analizó la , y graficando los intervalos para , (Figuras 1, 2), de igual forma se analizaron los datos transformados a logaritmo natural (Figuras 3, 4). Los coeficientes de variación calculados para cada grupo se presentan en el cuadro 1. Conclusión Los resultados obtenidos de los análisis para y usando los datos originales y transformados a logaritmo natural de P130 no indican cambios significativos a través del tiempo para ninguno de los dos parámetros, lo que coincide con los resultados de y sugiere que hay efectos importantes de escala que deben tomarse en cuenta para analizar este tipo de datos , por lo cual no podemos afirmar estadísticamente que para los datos utilizados en éste estudio haya habido una pérdida significativa de la variabilidad genética aditiva en respuesta al proceso de selección en el transcurso de los años posteriores al 2005. Todavía otra posibilidad es qu	poster
Data from OSM has been automatically categorised in several accessibility classes, in accordance with the national and regional legislation. Two different types of maps have been produced: current status, with footways, crossings, kerbs and obstacles represented, and project status, with modiﬁed elements included in the plan. 1000 kerbs mapped 400 crossings mapped 31% inaccessible kerbs 10000 images uploaded in Mapillary 60000 €/km costs estimated 155 buildings assessed 12 recurring situations 37 standard intervention typologies 10 meetings were organised in 10 different locations, corresponding to the 10 sub-departments of the city. The aim was to present the project and collaboratively decide the areas/paths to be mapped and where to assess accessibility during the following mappings events. 10 mapping events were organised with citizens and local organizations both as demonstration and training for the use of mapping tools (FieldPapers, Mapillary, OSMAnd), and for collection of local expertise on accessibility. Then expert mappers ﬁnalized the collection in information and the upload on OpenStreetMap. Various open tools have been used: FieldPapers during mapping events; OsmAnd during technical mapping; Mapillary for collection of street-level pictures; JOSM for editing OpenStreetMap data; QGIS for the production of ﬁnal cartographic maps of the ofﬁcial plan. PARTICIPATORY MEETINGS MAPPING The "PEBA - Piano per l'Eliminazione delle Barriere architettoniche" (Plan for the elimination of architectural barriers) is a legislative tool aiming at ensuring full accessibility of urban paths, spaces and buildings for all the people. The local administration of Padua ﬁnanced the creation of the PEBA of the city, with the brand "Padova + Accessibile" (Padua more accessible). More information at http://www.comune.padova.it/ peba. The two main criteria for the development of the plan have been a wide participatory vision and the use of open geospatial tools for analysis. OpenStreetMap has been selected as the core tool for mapping accessibility. elements. 10 meetings with citizens and associations 66 invited associations 40 km of footways/paths mapped 137 disabled designated parking spaces 370 geolocated +reports 229 obstacles observed 1.5 km of non-accessible sidewalks 17 km of sidewalks with limited accessibility OUTPUT MAPS CREDITS The local administration of Padua (Comune di Padova) funded the realization of the PEBA, including participatory meetings and mapping events and activities (contact person arch. Alberto Marescotti). Wikimedia Italia provided free patronage for mapping events; various Wikimedia Italia volunteers contributed to the mapping and editing activities. Image “Padova+accessibile” by arch. Alberto Marescotti. Font OpenDyslexic ®. Background image ©OpenStreetMap contributors. Project manager Elena De Toni. The PEBA (Plan for the elimination of architectural barriers) of the city of Padua has been the ﬁrst example in Italy of the direct use of OpenStreetMap as main tool to collect information and derive decisions for the characterization of accessibility of public areas and paths. In the area of Padua, data in OSM have been improved in relation to information on accessibility of public areas and path, especially for disabled people; in addition to this, through the involvement of citizens and local organizations, the use of open source technology and the revision and application of a tagging scheme for OpenStreetMap, accessibility information will be easily updated and extended in the future. CONCLUSIONS TAGGING SCHEME PEBA IN NUMBERS PEBA During the activities of the PEBA, a short guide on how to map parkings for people with disabilities was produced and then shared and promoted to a few associations working on disabilities. In 4 months the number of these parking spaces increased from 0 to ~140, allowing the production of a dynamic map that is being continuosly updated. PARKING SPACES This work is available at http:/	poster
Are Physicians Ready to Take up Leadership Roles in Planetary Health? Suraj Bhattarai1,2; Omary Chillo3; Biljana Gjoneska4; Dipendra Khatiwada5; Jaifred Christian F. Lopez6; Atiya Mosam7; Juan Carlos Núñez Enríquez8; Duha Shellah9; Nora Grasselli10 1Global Health Research & Medical Interventions for Development, Nepal; 2London School of Hygiene & Tropical Medicine, UK; 3Muhimbili University of Health and Allied Sciences, Tanzania; 4Macedonian Academy of Sciences and Arts, North Macedonia; 5College of Medical Sciences, Nepal; 6Duke University, USA; 7Mayibuye Health and University of the Witwatersrand, South Africa; 8UMAE Hospital de Pediatría CMN Siglo XXI, IMSS, Mexico; 9Palestine Academy for Science & Technology, Palestine; 10European School of Management and Technology, Germany. INTRODUCTION • Physicians’ role is primarily thought to provide patient care. • They also contribute to improve healthcare systems & health indicators.a • However, their role in planetary health has not been established nor defined yet. • Young Physician Leaders Programme (YPL) is a flagship training programme of the InterAcademy Partnership (IAP) – the parent academy of 149 national science academies worldwide.b • IAP has a mission to “foster the next generation of research and science policy leaders” by strengthening critical capacities for leadership.b REFERENCES aInstitute of Medicine (US) Division of Health Sciences Policy. Medical Education and Societal Needs: A Planning Report for the Health Professions. National Academies Press (US); 1983. Chapter 4, The Physicians’ Role in a Changing Health Care System. bThe InterAcademy Partnership. www.interacademies.org cMyers SS, Potter T, Wagner J and Xie M. Clinicians for Planetary Health. One Earth; 2022. dMoser AM, Stigler FL and Haditsch B. Physicians’ responsibility for planetary health. The Lancet Planetary Health; 2017. METHODS • A semi-structured questionnaire was developed based on literature review and distributed electronically to the 10-year YPL cohorts (2011- 2022), with assistance from the IAP Secretariat. • The 8-member YPL Alumni Steering Committee coordinated the study, in collaboration with the ESMT. • EMST ethics committee provided ethical clearance to the survey. • Descriptive statistics was used to analyse the data. RESULTS • Out of 235 physicians approached, 77 (33%) completed the survey. • 51% were female. Majority (73%) represented LMICs. • 52% of the respondents were engaged in clinical practice, 60% in research, 29% in strategic and policymaking roles, 14% in bureaucracy. CONCLUSIONS • Physicians are extending their work area beyond curative medicine, embracing upstream approaches to impact population health. • Therefore, it is important to acknowledge physicians as key stakeholders of planetary health and engage them in global initiatives. OBJECTIVE To explore the engagement of YPL alumni in health sector in the context of emerging global discourse on planetary health. Young Physician Leaders (YPL) at a glance • YPL programme is running since 2011. • It has 21 new members and 231 Alumni across 5 continents. • Each year, national academies send their nominations to IAP and its expert medical panel selects the new cohort (~20 members). • World Health Summit, M8 Alliance and European School of Management and Technology (ESMT) are main programme partners, among others. • While 30% of the respondents worked from central or federal level, the majority (58%) worked from local level (district or community facilities). DISCUSSION • Physicians’ community represent highly educated and respected professionals and apt science communicators, so they could be the most suitable messengers/ debaters/ negotiators for planetary health.c • Next generation physicians should be educated to recognize planetary health as the foundation for any efforts to improve human health.d May 27-29, 2024 Geneva, Switzerland Contact: Dr. Suraj BHATTARAI Director and Investigator GLOHMED, Nepal E: surajbhattarai.m	poster
X-ARAPUCA as photon detection system of SBND Ana Machado for SBND Collaboration NEUTRINO 2024 June 16-22, 2024 – Milan, Italy Three LArTPC detector to study short range neutrino oscillation • Neutrino-argon interactions at GeV energy scale. Millions of nµ and thousands of ne from two neutrino beams • Verify the “low-energy excess” anomaly Investigate the excess of ne observed by MiniBooNE experiments • Search for sterile neutrino Discover or exclusion of 1 eV-scale sterile neutrino mass region • Beyond Standard Model Physics 192 X-ARAPUCA 176 ARARA readout SensL - 3x3m2 SiPM. (C-series 30050-A1) 88 VUV OPTO 400nm PTP coating EJ286 88 Visible OPTO 450nm EJ280 16 APSAIA readout Hamamatsu - 6x6m2 SiPM. (S13360-6050 VE & HS) 8 VUV OPTO 400nm PTP coating Glass to Power 8 Visible OPTO 450nm Glass to Power FILTER (400nm cutoff) PTP (emission 350nm) SiPM WLS plate LAr scintillation light FILTER (450nm cutoff) SiPM WLS plate Visible light Photon Detection System Active elements: on the PD-BOX, behind the anode. • 120 8” Hamamatsu Cryogenic PMT’s (96 TPB coated + 24 uncoated) • 192 X-ARAPUCA (96 VIS + 96 VUV) Passive element: at the cathode. Wavelength-Shifting Reflective plates (TPB coated) 64 double-sided Short Baseline Near Detector TPC Cathode Plane at -100 kV divides the detector into 2 drift volumes. Drift distance is 2 m, drift time is 1.28ms Anode Plane on either side. Each consists of 3 planes of wires with 3 mm spacing and different angle per plane. Total of 11,260 wires Cold (89K) Electronics to pre-amplify and digitize signals Field Cage that wraps around the 2 LArTPCs to step down the voltage & ensure uniform electric field of 500 V/cm. Cosmic Ray Tagger (CRT) Scintillator strips with SiPM readout 142x32 channels X-TDB X-ASB All PCB boards were tested in cryogenic temperature 60 SiPMs was tested - 48 6050-VE (VBr = +53V @RT) - 12 6050-HS (VBr = +38V @RT) A total of 777 X-TDBs were tested at the LN2 temperatures and able to see light. 704 were required. Only 1 “bad” board was identified Digitized signal from the HS test – APSAIA – ARAPUCA POWER SUPPLY AND INPUT AMPLIFIER – ARARA – ARAPUCA ANALOG READOUT AMPLIFIER Readout Electronics The APSAIA will power the SiPMs and amplify their 32 output signals. It is hosted in the outer flange of SBND. Each board has 8 channels with input connectors. The power supplies are designed to meet the SiPMs' requirements, and the amplifiers process the SiPMs' output signals. Each channel has an MCX output connector. The power supply and serial port connector use a standard DB15 connector. The supply voltage for the SiPMs is remotely adjustable up to 60 V with a resolution of less than 100mV. The power supplies and amplifiers are controlled by a microcontroller connected to an RS232C port. RJ45 à DB37, cold side view The preamplifier board conditions and biases the signal between the X-ARAPUCA light collection hardware and the signal capture hardware The bias voltage must be programmed remotely using an RS232c. The power supply is available via a cable with a DSUB9 connector. The 352 signals for flange are inputs for ARARA board. Into the ARARA board the signals are ganged by 4. RAVANA board convert signals from the ARARA to the CAEN 1740 digitizers Single-channel prototype of the pre-amplifier by AGE scientific These preamp modules are: - Double width 6U VME cards in custom crate. - Powered by externally provided 8V DC - 64 input channels for 16 output channels - Compliant with FNAL Electrical Design Standards for Electronics The amplifier characteristics are as follows: - Minimum gain of 20, adjustable via microcontroller if other gain values are needed. - Sufficient bandwidth for processing 30 ns rise-time signals, DC-coupled. - Output impedance of 50 Ω. ASSEMBLY & INSTALLATION 1o step: The assembly of the mechanical and optical parts (dichroic filters and light guide) was done at Unicamp 2 o step : The PCB board installation in each X- ARAPUCA was carried out at Fermilab. Finally, 4 VUV X-A	poster
Comparison of fatty acid composition in grass-fed and grain-fed horse meat Aidyn Igenbayev, Shyngys Amirkhanov, Muhtarbek Kakimov, Alida Kanabekova S. Seifullin Kazakh Agrotechnical University, Astana, Kazakhstan Reference: Igenbayev, A., Amirkhanov, S., Ospankulova, G., Kardenov, S., Baytukenova, S., & Ali Shariati, M. (2022). Determination of the fatty acid composition and fatty acids trans-isomers in the horse, stall horse, mutton, beef and pork meat. Potravinarstvo Slovak Journal of Food Sciences, 16, 800–809. https://doi.org/10.5219/1799 The objective of this research was to analyze the fatty acid composition of horse meat. The study involved the selection of two distinct groups of horses: 1) horses that were raised and fed in a pasture; 2) horses that were kept in stalls. For the analysis, pasture horse meat (Kazakh horse breed), and stall horse meat (Kazakh horse breed) were purchased from meat markets and supermarkets in Astana, Kazakhstan. Samples were obtained from four diﬀerent carcass muscles (back muscles, thigh muscles, rib muscles, neck muscles) of each animal, an average of 500 grams of sample. The samples obtained were stored at a temperature of - 18 ºC. Horse meat for pasture and stall keeping was supplied from farms engaged in horse breeding in an appropriate way of feeding. This analysis compares the fatty acid composition of grass-fed and grain-fed horse meat, speciﬁcally in the loin cut. The data shows that grain-fed horse meat has a higher percentage of saturated fatty acids (SFA) compared to grass-fed horse meat, with the content being 40.32% and 37.43% respectively. Conversely, grass-fed horse meat has a higher percentage of monounsaturated fatty acids (MUFA) compared to grain-fed horse meat, with the content being 48.12% and 40.36% r e s p e c t i v e l y. T h e p e r c e n t a g e o f polyunsaturated fatty acids (PUFA) is also higher in grain-fed horse meat compared to grass-fed horse meat, with the content being 19.31% and 14.44% respectively. Table 1. Fatty acid content in muscle lipid fraction of grass fed horse meat, % of total fatty acids Table 2. The fatty acid content in the muscle lipid fraction of grain-fed horse meat, % of total fatty acids This study reports the levels of trans fatty acids (TFAs) in diﬀerent cuts of grass-fed horsemeat, revealing that the TFA content varies across cuts with the highest level in loin (1.85%) and the lowest in round (1.66%). The levels of TFAs in rib (1.68%) and neck (1.70%) are similar to each other and fall in between the levels observed in loin and round. This study presents data on the levels of trans fatty acids (TFAs) in various cuts of grain-fed horsemeat, revealing that the TFA content is markedly higher in round (5.54%) and neck (5.52%) than in loin (2.75%) and rib (3.56%). These ﬁndings suggest that the TFA content in horsemeat can be inﬂuenced by the type of feed given to the animals. As high intake of TFAs has been linked to increased risk of cardiovascular disease, these results provide important information for assessing the potential health risks associated with the consumption of grain-fed horsemeat. This comparison suggests that the type of diet fed to horses can have a signiﬁcant impact on the fatty acid composition of their meat. The higher content of SFAs in grain-fed horse meat may increase the risk of cardiovascular disease, while the higher content of MUFAs in grass-fed horse meat may have potential health beneﬁts. The higher content of PUFAs in grain-fed horse meat may also be beneﬁcial, as PUFAs are essential fatty acids that have been linked to a reduced risk of cardiovascular disease. However, the speciﬁc types of PUFAs present in grain-fed horse meat should be taken into consideration, as some types of PUFAs may be more beneﬁcial than others. Further studies are needed to explore the health implications of consuming grass-fed vs. grain- This research is funded by the Ministry of Agriculture of the Republic of Kazakhstan (BR1076499	poster
Analysis 大質量星 Telescope Resolution Reference !"CO(2 −1) ALMA 1.12” (53 pc) Leroy et al. (2021) Hα VLT 0.92” (44 pc) Emsellem et al. (2022) Giant molecular clouds and their Type classification in M74 Fumika Demachi 1, Yasuo Fukui 1, Kengo Tachihara 1, Rin Yamada 1, Kazuki Tokuda 2,3, Shinji Fujita 4, Masato Kobayashi 5 Kazuyuki Muraoka 6, Ayu Konishi 6, Tsuge Kisetsu 4, Toshikazu Onishi 6, Akiko Kawamura 3 (Nagoya university 1, Kyushu university 2, National Astronomical Observatory of Japan 3, University of Tokyo 4, University of Cologne5, Osaka Metropolitan university 6 ) 1. 3. Need to expand samples to establish a general picture of GMC evolution. [ The goal of this study ] Establish the method of Type classification based on 𝐿!" Suitable for resolving GMCs without contamination in a line of sight Distance: 9.7 Mpc (Anand et al. 2021) Inclination: 8.9° (Lang et al. 2020) 𝑀()+ = 10,-./0𝑀⊙, 𝑀23 = 104.5-𝑀⊙ (Leroy et al. 2021) M74 Giant molecular clouds (GMCs) are the main star formation sites and their evolutions are important to understand galaxy evolution. In this poster, we discuss GMC evolution in nearby spiral galaxy M74 by using spatially resolved GMC samples. We classified GMCs into 3 types based on Hα luminosity (𝐿67) of HII regions with GMCs, and Type I (without star formation) are 58, Type II (with 𝐿67 < 10/5.8 erg s9,) are 202, and Type III (𝐿67 > 10/5.8 erg s9,) are 172, then obtained these results, (1) the young star clusters clearly associated with Type II and III GMCs, and 𝐿67 and cluster mass show tight correlation for Type III (2) massive Type I GMCs show the sign of embedded star formation and Type II GMCs are affected by extinction more than Type III, and (3) Type III are the most virialized state. For these results, we interpreted GMC Type classification as GMC evolutionary sequence from Type I to III with active star formation. In this study, Type classification are applied in grand design spiral galaxy out of the local group for the first time. 1. Identify GMC by PYCPROPS1 and HII region by Astrodendro2. 2. Determine the association between GMC and HII region if their boundaries are overlapped, and classify GMCs based on 𝐿2:. 3. Compare Type GMCs with clusters3 obtained by HST and 21 µm emissions4 obtained by JWST to check consistency with results of LMC and the effects of Hα extinction, respectively. → Classify GMCs based on Hα luminosity (𝐿67) 10/5.8 erg s9, of associated HII regions because Hα is more uniformly surveyed Results 4. We identified 58 Type I, 202 Type II, 172 Type III (Fig.1). The median of GMC mass and radius increase Type I<II<III. Type III GMCs are in the most virialized states (Fig.2). 1-4 Myr clusters are located closer to GMCs than typical GMCs separation (Fig. 3). GMC evolution 5. Fig.2 → Type III GMCs are most gravitationally relaxed. Conclusions 6Type classification base on 𝐿2: is useful method to distinguish different evolutionary phases as tested in M74, out of the Local group, for the first time. Extend into other galaxies to validate the universality and for the future work. Assume GMCs evolve steadily and the timescale of Type III is 4 Myr based on associated cluster age. Estimate the timescale of Type I and II by the ratio with Type III statistically → Type I: 1Myr, Type II: 5Myr, Type III: 4Myr [Problem] GMC [Type I ] No star formation [Type II ] With HII region (𝐿!" < 10#$.&) [Type III ] With HII region (𝐿!" > 10#$.&) HII region 1: Rosolowsky et al. 2021, 2: Rosolowsky et al. 2008, 3: Adamo et al. 2017, *4: Lee et al. 2023 Fig.3) Histogram of separation between nearest GMCs and clusters. The orange line indicates typical GMC-GMC separation. Fig.4) Scatter plot between total cluster mass and Hα luminosity associated common GMCs. The size of marker indicate the number of clusters with each GMC. The cluster mass increase with 𝐿2: especially for Type III (Fig. 4). 35% of Type I and more than 80% of Type II and III are associated with 21 µm emission. Correct Hα extinct lu	poster
Ergebnisse • Diskriminanzfähigkeit zw. Bildern η2T1 = .28, η2T2 = .33 • Inter-Rater-Reliabilität ICCT1 = .81, ICCT2 = .84 • Test-Retest-Reliabilität r = .93 • Hauptkomponentenanalyse 8-Faktorenlösung • Tucker-Korrelationskoeffizient rT1 = \|0.82\|, rT2 \|1.00\| Empirische Bildanalyse Validierung von RizbA an bildnerischen Arbeiten erwachsener Laiinnen Schoch K.1,2 & Ostermann T.1 1 Universität Witten/Herdecke, Fakultät für Gesundheit, Department Psychologie und Psychotherapie 2 Hochschule für Künste im Sozialen, Ottersberg, Institut für Kunsttherapie und Forschung Hintergrund Literatur Epstein, C. (2019, 22. März). Bildlicher Ausdruck von Depression: Erprobung des Ratinginstruments RizbA an Bildstichproben aus dem klinischen Kunsttherapiesetting. Zenodo. https://doi.org/10.5281/zenodo.3365921 Janßen, B. (2018, 31. August). Erprobung des Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA): Ansatz zu einer möglichen Untersuchung des bildnerischen Ausdrucks von Schmerz in gemalten Bildern von Menschen mit chronischer Schmerzsymptomatik. Zenodo. https://doi.org/10.5281/zenodo.3407808 Schoch, K., & Ostermann T. (under review). Psychometrics of art: Validation of RizbA, a quantitative rating instrument for pictorial expression. Psychology of Aesthetics, Creativity and the Arts. Schoch, K. (2018). Ratinginstrument für zweidimensionale bildnerische Arbeiten (RizbA): Fragebogen in deutscher Sprache. Zenodo. DOI:10.5281/zenodo.2530858 Schoch, K. (2018). Jenseits von gut und schön: Entwicklung eines quantitativen Ratinginstruments für zweidimensionale bildnerische Arbeiten (RizbA). Musik-, Tanz- und Kunsttherapie: Zeitschrift für Künstlerische Therapien im Bildungs-, Sozial- und Gesundheitswesen. 28(2), 131-138. https://doi.org/10.5281/zenodo.1479716 Schoch. K., Gruber. H., & Ostermann, T. (2017). Measuring art: Methodical development of a quantitative rating instrument measuring pictorial expression. The Arts in Psychotherapy, 55, 73-79. https://doi.org/10.5281/zenodo.1479694 Diskussion • Reliabel und generalisierbar auf Bildmaterial von Laiinnen • Praxisdokumentation, Grundlagen- und Anwendungsforschung Dokumentation und Analyse von Bildern und Prozessen Korrelationen mit anderen Konstrukten Gruppenvergleiche • Abgeschlossen Dritte Validierungsstudie an Gegenwartskunst • Durchgeführt Pilotstudien zu spezifischen Populationen Chronische Schmerzsymptomatik (Janßen, 2018) Rezidivierende Depression (Epstein, 2019) • In Entwicklung Manual • In Planung Machine Learning-Ansätze kerstin.schoch@hks-ottersberg.de www.kunsthochzwei.com/forschung Tab.1. Antwortformat: Sechsstufige Likert-Skala trifft überhaupt nicht zu trifft nicht zu trifft eher nicht zu trifft eher zu trifft zu trifft voll- kommen zu ✘ Limitierung Weitere Validierung Faktorenstruktur CFA, SEM Weitere Populationen Bildmaterial und Rater*innen Tab.2. Fragebogen: Items und deren Gütekriterien (T1) Nr. Itembeschreibung pi si2 𝛈2 ICC 1 Das Bild enthält zeichnerische Elemente .58 1.31 .52 .96 2 Das Bild enthält malerische Elemente .61 0.92 .41 .93 3 Die Darstellungsweise ist gegenständlich .43 1.67 .63 .97 4 Die Darstellungsweise ist abstrakt .61 1.19 .52 .96 5 Der Farbauftrag ist pastos .33 0.63 .31 .90 6 Die vorherrschende Farbgebung ist leuchtend .58 1.08 .52 .96 7 Im Bild befinden sich vorwiegend reine Farben .47 0.52 .28 .88 8 Im Bild befinden sich vorwiegend Mischfarben (Sekundärfarben) .50 0.72 .36 .92 9 Im Bild sind Komplementärkontraste vorhanden .51 1.34 .51 .96 10 Im Bild enthaltene Formen sind vorwiegend organisch .52 0.65 .34 .92 11 Im Bild enthaltene Formen sind vorwiegend geometrisch .39 0.98 .46 .94 12 Die Linienführung verläuft vorwiegend gebogen .55 1.07 .50 .95 13 Die Linienführung verläuft vorwiegend eckig .30 0.90 .49 .95 14 Das Bild enthält unbearbeitete Flächen .53 1.72 .51 .96 15 Das Bild wirkt tief .32 0.44 .29 .88 16 Das Bild ist perspektivisch .33 0.62 .34 .91 17 Das Bild ist frei von Perspektive (aperspektivisch) .60 0.71 .31 .90 18 Das Bil	poster
El riesgo CV , se define como la probabilidad de un individuo de tener un evento cardiovascular en un período de tiempo determinado (por ejemplo, en los próximos 5 o 10 años). La ecuación de riesgo de Framinghan define como un primer evento CV al IAM, angina de pecho, ataque cerebral isquémico, enfermedad vascular periférica, insuficiencia cardíaca congestiva o una muerte cardiovascular. El objetivo de hacer una evaluación del riesgo CV es identificar los factores de riesgo, estimar el riesgo de hacer un evento CV y utilizar este cálculo para hacer un manejo terapéutico apropiado de aquellos factores. El presente estudio se llevo a efecto en los CS. San Lorenzo , Pile , El Aromo , Manantiales , San Mateo , con una población de 32 personas , de las cuales se evidencia que 27/32 presenta un RCV bajo , 2/32 presenta un riesgo MUY ALTO , por ser diabéticos , y de riesgo moderado 3/32. Lo que llamo la atención fue que de los 32 evaluados 22 presentan SOBREPESO y 4 con OBESIDAD , además que el 100% del grupo es SEDENTARIO . Al momento no se encuentra implementado un programa de salud preventiva en nuestro distrito de salud , cosa alarmante , por eso la pregunta ¿ Se preocupa la salud por nuestra salud?? Quien se preocupa por que los funcionarios tengan SALUD ¿?.Los múltiples requerimientos no solo en el trabajo clínico si no administrativo absorbe de forma casi total el tiempo de los trabajadores , dando lugar al desarrollo de patologías que silenciosamente evolucionan tanto en la salud cardiovascular como HTA, DM , DLP , OBESIDAD , Problemas de salud mental como trastornos ansiosos , depresión etc . Es necesario la implementación de medidas que nos protejan , asegurando bienestar SALUD a los trabajadores del área de la salud , en aras de mejor atención a nuestros usuarios y al mejoramiento de el sistema de salud del país. RIESGO CARDIOVASCULAR EN EL PERSONAL DEL DISTRITO DE SALUD NUMERO DOS SECTOR RURAL SCORE DE FRAMINGHAN UNIVERSIDAD DE PIURA MAESTRIA EN SALUD OCUPACIONAL ¿ Hay salud en la salud? Distribución del Personal de salud del área rural , distrito 2 BAJO 5% MODERADO 5-9% ALTO 10-19% MUY ALTO 20 o > 0 2 4 6 8 10 Serie1 0 5 10 15 20 25 SOBREPESO BIBLIOGRAFIA . 1.Programa de Salud Cardiovascular. Reorientación de los Programas de Hipertensión y Diabetes. Ministerio de Salud de Chile. 2002 . Prevención Primaria de Enfermedad Coronaria. Tablas de Framingham para la estimación de riesgo coronario a 10 años adaptadas a la población chilena. Programa de Investigación de Factores de Riesgo de Enfermedad Cardiovascular. 2007. Universidad de Talca. http://pifrecv.utalca.cl . Determinación y Prevalencia de Factores de Riesgo Cardiovascular en el Personal de la Brigada de Caballería Blindada No 11 Galápagos, Riobamba ELABORADO POR: DRA SUSANA JASMIN CABRERA MERO MANTA OCTUBRE 2014 RIESGO CARDIOVASCULAR 22 PCTES CON SOBREPESO 4 CON OBESIDAD	poster
We wish to thank the Allen Institute founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support. An integrated imaging and staining platform for cubic millimeter scale array tomography Forrest Collman, Robert Seraﬁn, Sarah Davis, Olga Gliko, Tom M Keenan, Kristy Parker, Linnaea E Ostroﬀ, Stephen J Smith Synapse Biology Department, Allen Institute for Brain Science, Seattle WA 98103 Array tomography (AT) involves reconstruction of images acquired from arrays of serial ultrathin sections, which can be imaged by fluorescence microscopy (FM-AT) for proteometric analysis, or by scanning electron microscopy (EM-AT) for higher resolution. Axial resolution is defined by the thickness of physical sections (50-200 nm); the lateral resolution of FM imaging is optimal given the direct adhesion of sections to an optical coverslip. However, the throughput of data acquisition is slowed by the image acquisition time, and the need for human intervention to stain and set up samples on the microscope. The first AT systems acquired data at a throughput of ~16 seconds per 4 channel image (Micheva 2007). Recent work incorporated a hardware-based autofocus technology that improved throughput to 5-12 sec per 4 channel image (Rah 2013), achieving 0.1 mm3 in 878 imaging hours with 200 nm-thick sections. Data acquisition throughput is further impaired by the overhead involved in staining and setting the sample up for imaging. As part of the Open Synaptome Project (http://opensynapto.me) effort to improve all aspects of ATomo based synaptic analysis, we are developing a next-generation system to achieve imaging throughput on the order of 0.2mm3 per day per microscope. We will describe the design of the imaging system, which include hardware-based autofocus, large format sCMOS sensors, motionless high intensity wide-field laser illumination, and a custom open-source software solution. We will also describe our efforts to construct a robofluidic staining solution fully integrated with the microscope. Our goal is to enable continual staining and imaging without human intervention, thus increasing both throughput and consistency of results ultrathin section onto coverglass IF stain IF imaging poststain FESEM elution ABSTRACT ARRAY TOMOGRAPHY IMAGING brain-map.org alleninstitute.org y (mm) 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 Wash In x (mm) y (mm) Wash Out 0 ul 50 ul 100 ul 150 ul 200 ul 250 ul 300ul Fluorescein Intensity (AU) 0 500 100 200 300 400 x (mm) 300ul 0 10 x (mm) >95% washin with 200-250ul >99% washout with 300 ul Non-saturating/quenching concentration of fluoroscein 10x air objective, median intensity of field, 50μl increments Fully automated pipetting and image acquisition across x,y grid Pipette In Pipette Out 1.5 mm 3.25 mm pipetting robot inverted microscope 96-well chiller tips 45 mm 3D printed mold PDMS (Sylgard) poured mold Passive pumping design allows simple unpowered flow-cell compatible with vertical pipetting robot (Walker 2002) PASSIVE PUMPING FLOW CELL PROTOTYPE MOSAIC PLANNER - OPEN SOURCE ARRAY TOMOGRAPHY SOFTWARE REFERENCES AND GRANT SUPPORT COVERSLIP FLATNESS LASER ILLUMINATION time per 4 channel frame (sec) auto-focus filter-change exposure stage move Standard Upright Automated Microscope Zeiss Observer Z.1, 4 filter cubes, x-cite mercury halide liquid light guide IMAGING SPEED IMPROVEMENTS Improvement 16.1 sec per 4 images 892 images/hour hardware auto-focus (Rah et al. 2015) 100-400ms focus time ~2000 images/hour Estimated Speed Increase ~10-50 ms change time ~4000 images/hour quad band dichroic illumination switching sCMOS field size 4.2 vs 1.4 megapixels effectively 2.9x faster laser illumination ~5x power density ~12,000 images/hour NET IMPROVEMENT ~40x faster net imaging 500 nm X Y XY PSF 500 nm Z Y YZ PSF 50 100 1 nm/μm across 200 μm 500μm μmanager Core API hardware agnostic microscope commands images/status Camera Illumination Stage Microsc	poster
ZENTRUM Für nachhaltiges Forschungsdatenmanagement Literatur Huschka, Denis et al. (Hg.) (2013): Forschungsinfrastrukturen für die qualitative Sozialforschung. Berlin: Scivero. RatSWD (Hg.) (2018): Archivierung und Zugang zu qualitativen Daten. RatSWD Working Paper 267/2018. Berlin: Rat für Sozial- und Wirtschaftsdaten (RatSWD). https://doi.org/10.17620/02671.35 Steinhardt, Isabel et al. (2020): Das Öffnen und Teilen von Daten qualitativer Forschung. Ergebnisse eines Workshops der Forschungsgruppe „Digitalisierung der Wissenschaft“. Weizenbaum Series 6. Berlin: Weizenbaum Institute for the Networked Society. https://doi.org/10.34669/wi.ws/6 POSTER Möllenkamp, Andreas (2020): Öffnen und Teilen von Interviews. Ein Leitfaden. Zenodo. DOI: https://doi.org/10.5281/zenodo.3925304 Lizenz Dieses Werk ist lizensiert unter der Lizenz Creative Commons Attribution 4.0 International (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ PROJEKT Das Poster ist entstanden im Rahmen des Projekts Open Interviews. Auf dem Weg zur Öffnung qualitativer Interviewforschung. Weitere Informationen: https://w.wiki/Vkp Das Projekt wurde das 2018/2019 im Rahmen des Fellow-Programm Freies Wissen von Wikimedia Deutschland, dem Stifterverband für die Deutsche Wissenschaft und der VolkswagenStiftung gefördert. KONTAKT Andreas Möllenkamp Universität Hamburg Zentrum für nachhaltiges Forschungsdatenmanagement Monetastr. 4 20146 Hamburg Tel.: +49 40 42838-7231 andreas.moellenkamp@uni-hamburg.de www.fdm.uni-hamburg.de https://orcid.org/0000-0002-5750-0220 https://twitter.com/andreasmoellen21 Vorbereitung und Planung Bei Qualifikationsarbeiten: Sprechen Sie mit Ihren Betreuerinnen über das Archivieren, Öffnen und Teilen von Interviews. Einen Überblick über das Öffnen und Teilen von Daten qualitativer Forschung bietet Steinhardt et al. (2020). Reflektieren Sie, ob in Ihrem Projekt durch das Öffnen und Teilen ein Eingriff in den Forschungsprozess entstehen würde. Eine Beeinflussung der Interviewsituation können Sie umgehen, indem Sie Fragen der Archivierung und Zugänglichmachung erst nach dem Interview besprechen, beispielsweise auf Grundlage des Interviewtranskripts.3 ÖFFNEN und Teilen von Interviews Ein Leitfaden Informieren Sie sich über geeignete Forschungsdaten-Repositorien. Der Rat für Sozial- und Wirtschaftsdaten akkreditiert Forschungsdatenzentren: www.ratswd.de/forschungsdaten/fdz/ qualitativ Das Forschungsdatenzentrum Qualiservice hat sich auf die Archivierung und Bereitstellung von Interviews und anderen qualitativen Daten aus der Sozialforschung spezialisiert. Lassen Sie sich dort beraten und planen Sie Zeit und Kosten für die Archivierung ggf. in Ihrem Förderantrag mit ein. www.qualiservice.org/ Illustrationen: digitalbevaring.dk (CC-BY 2.5 DK) Durchführung Dokumentation und Kontextualisierung: Für eine gute Nachvollziehbarkeit und Nachnutzbarkeit ist eine möglichst umfassende und prozessbegleitende Dokumentation und Kontextualisierung Ihrer Interviews wichtig. Dazu gehören die Mitglieder Ihres Forschungsteams, die Erläuterung der Auswahl Ihrer Interviewpartnerinnen, die Kommunikation vor dem Interview, der Kontext der Interviewsituation sowie die weiteren Bearbeitungs- und Auswertungsschritte. Datenschutz: Als Forscherin sind Sie verpflichtet, verantwortungsvoll mit den personenbezogenen Daten Ihrer Interviewpartnerinnen umzugehen. Nach der Datenschutz-Grundverordnung (DSGVO) dürfen personenbezogene Daten nur für festgelegte, eindeutige und legitime Zwecke erhoben und verarbeitet werden. Darüber hinaus sind die Landesdatenschutzgesetze für öffentliche Hochschulen in Deutschland einschlägig. Die Erhebung, Verarbeitung und Archivierung von personenbezogenen Daten bedarf daher der informierten Einwilligung Ihrer Interviewpartnerinnen. Informierte Einwilligung: Die Einwilligungserklärung einer Interviewpartnerin setzt voraus, dass Sie sie über Ihre Forschungsabsicht, das Vorgehen, die konkrete Nutzung der Daten und die Rechte der beforscht	poster
Collaborative Research: Elements: ROCCI: Integrated Cyberinfrastructure for In Situ Lossy Compression Optimization Based on Post Hoc Analysis Requirements PIs: Sheng Di1,2, Franck Cappello1,2, Dingwen Tao3 1University of Chicago, 2Argonne National Laboratory 3 Indiana University Motivation Libpressio Z-Checker/QCAT Objectives This project aims to develop a Requirement-Oriented Compression Cyber-Infrastructure (ROCCI) for data-intensive domains such as astrophysics and materials science. The core purpose is practicality, enabling scientists to efficiently assess and/or optimize the lossy compression quality based on their post hoc analysis requirements. This project advances knowledge with three key thrusts: • It builds an efficient layer to interoperate with different lossy compressors and diverse post hoc analysis requirements on data fidelity by leveraging our developed compression adaptor library (LibPressio) and compression assessment library (Z-checker). • It develops an efficient engine to determine the best compressor with automatically tuned optimized settings. • It develops a user-friendly infrastructure integrating compression optimization and execution via HDF5 dynamic filter mechanism. Acknowledgement Z-checker is a parallel framework for assessing lossy compression of scientific data efficiently. QCAT is the corresponding lightweight utility library and toolkit. This research is supported by NSF OAC # 2104023 and 2104024. We acknowledge the computing resources provided on Bebop (operated by Argonne Laboratory Computing Resource Center and on Theta and JLSE (operated by Argonne Leadership Computing Facility). Publications Estimation error and cost of SECRE for SZx: When using a large sampling stride such as 40 (sampling rate would be 1/41≈2.43%), the estimation error is still very low less than 1% in the worst case). System Architecture of ROCCI with improved & innovative modules. We are towards the end of the second year of the project. In the first two years, we have 20+ papers published in top conference/journal papers, including SC, ICDCS, ICDE, IPDPS, HPDC, ICS, VLDB, EuroSys, IJHPCA, HiPC, etc.. Major Accomplishments First year: We improved Libpressio to support 30+ compressors (both lossy and lossless, both CPU and GPU) and Z-checker/QCAT to support 40+ compression assessment metrics (including ratio, speed, max error, PSNR, SSIM, derivatives, distribution of errors, auto- correlation of errors, visualization, etc.) Second Year: We explored a series compression quality estimation methods, by leveraging machine learning (ML), statistical analysis, compression-principle analysis (surrogate), sampling method, etc. We also improved the performance for Libpressio, Z-checker/QCAT, SZ3, SZx, and developed new capabilities such as QoZ, FAZ. Libpressio-Predict Compression Ratio Estimation Evaluation using 4 real-world science datasets including climate simulation, cosmology research, large-eddy simulation, etc. LibPressio provides a productive interface for integrating compression. It eases experiment with new compressors with less code and complexity. Compression developers benefit from using a common implementation for a parallel compression; a CLI; Python, Rust, Julia, C, C++ bindings; and HDF5, ADIOS2, and other integrations that are complete and consistent with just 1 C++ class. 1 API 32+ compressors Builtin Provenance Support Optional Automatic Configuration and Optimization CPU Parallel and GPU Parallel Compressors Non-measurable overhead CLI, Python, Rust, Julia, C, and C++ bindings LibPressio addresses all these issues by providing a unifying interface with advanced engines for provenance and configuration optimization. LibPressio-predict integrates quite a few compression ratio and metric estimation algorithms for error-bounded lossy compression, including FXRZ, SECRE, Stats-based compresibility estimation method, etc. We have developed multiple efficient compression quality estimation methods and error-con	poster
Innovative Research for a Sustainable Future www.epa.gov/research Keith Houck \| houck.keith@epa.gov \| 919-541-5519 Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening Houck K1, Kleinstreuer N2, Yang J3, Berg E3, Knudsen T1, Richard A1, Martin M1, Reif D4, Judson R1, Polokoff M3 1 National Center for Computational Toxicology, Office of Research and Development, US EPA, Research Triangle Park, NC; 2ILS, Inc., Research Triangle Park, NC; 3BioSeek, a Division of DiscoveRx, South San Francisco, CA; 4NCSU, Raleigh, NC Abstract Summary Results The ToxCast Phase II library was screened in 8 complex cell culture systems measuring endpoints relevant to inflammatory signaling and vascular biology. Assays showed strong reproducibility across technical replicates and built-in test compounds. The BioMAP system identified potential targets, modes of action, and clinical side effects for compounds based on the reference database. Assays provided coverage of mechanisms/targets not directly represented in assay endpoints, e.g. AhR Phenotypic screening and computational analysis provides a unique opportunity to survey environmental chemicals for potential human bioactivity Methods Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing. However the quantity of chemicals needing assessment and challenges of species extrapolation require development of alternative approaches. Using 8 primary human cell systems (BioMAP), we screened in concentration-response format 776 chemicals from the ToxCast Phase II library (http://epa.gov/ncct/toxcast/chemicals.html) for perturbation of physiologically important pathways. Cell systems consisted of combinations of endothelial, peripheral blood mononuclear, bronchial epithelial and coronary artery smooth muscle cells; fibroblasts and keratinocytes. Chemical-response signatures from 87 endpoints covering molecular functions relevant to toxic and therapeutic pathways were generated. Assessment of profiling data by unsupervised clustering using Self Organizing Maps and supervised analysis using Support Vector Machine algorithms grouped chemical/concentration by potential mechanism class providing insight into polypharmacology and potential off-target effects of drugs. Clusters contained diverse mechanistic activity including kinase, TNFα, phosphodiesterase and Hsp90 inhibitors; Ah, estrogen and glucocorticoid receptor modulators; disruptors of mitochondrial and tubulin function; histamine antagonists; and statins. Novel associations identified included induction of tissue factor in endothelial cells by ER antagonists, AhR agonists and mTOR inhibitors, all chemical classes with susceptibility to venous thrombosis. Further, structure-based analysis demonstrated associations between chemical categories and mechanism class predictions. Our results yielded an extensive list of potential toxicological targets and biological pathways that we are incorporating into a chemical prioritization strategy for chemicals of concern to the Agency. Objective Use primary human cell phenotypic responses to classify and predict compound mechanisms of action and potential toxicities Primary Cell Systems Used SVM Models and Top Scoring Compounds • Compounds were tested at 4 (or 8) concentrations in duplicate, 200 mM high concentration with half-log dilutions. • Cells treated with compounds followed at one hr by stimulation of signaling pathways • Cells harvested at 24 hr and endpoints measured by ELISA or staining (SRB) • Data normalized to log10 Fold Change over DMSO controls • AC50 values calculated using 4-parameter Hill model • Compounds tested in blinded fashion and included internal replicates • Predictive models for 28 mechanism classes were built using a two class approach with SVM using R SVM package e1071 (Berg et al., JBS 18:1260, 2013). • Unsupervised clustering of all compounds at the individual concentration level was conducted	poster
Key partners: Sewer Mining (SM) technology is a mobile wastewater treatment system in containers able to extract wastewater from local sewers, treat it directly and reuse at the point of demand in dense urban environments. The unit consists of a membrane bioreactor unit (MBR) and a UV disinfection component and produces high quality reclaimed water for irrigation and for aquifer recharge during the winter. The SM unit has an annual capacity of about 9.000 m3 of reclaimed water Treatment residuals are collected, treated locally in the site and are transformed to an eco-friendly fertilizer (compost), when merged with green waste from pruning. Implemented technology The technology has been tested for over 1.5 year. Sampling and analysis activities have been implemented at a weekly basis and the main results that are illustrated in the table and the diagrams are summarized below: • SM produces water of a quality that meets all national and international criteria for unrestricted irrigation and urban use • Achieves complete elimination of organic carbon and pathogenic content • Provides reduction of pathogens due to MBR filtration process (without addition of chemicals avoiding production of secondary pollutants) • UV disinfection unit showed great performance • System works automatically and is remotely monitored in terms of operation and quality performance. Parameters Influent Effluent after UV disinfection Legislation Limits TSS 253± 97 ≤ 2 for 80% of samples ≤2 for 80% of samples ≤10 for 80% of samples BOD5 216 ± 64 8,6 ± 2,4 3 ≤10 for 87% of samples ≤10 for 80% of samples COD 695 ± 97 24,2 ± 4,1 3 - TN 81 (average) 5,5 ± 1,4 3 ≤ 15 NH4-N 5 ± 3 0,2 ± 0,19 3 ≤ 2 TP 10 ± 1.4 1,57 (average) - Turbidity - 2 (median) ≤ 2 (median) Conductivity 1,109 ± 75 1,067 ± 0 - pH 7.1 ± 0,2 7.5 ± 0,3 - TC >10 2 for 80% of samples 9 for 95% of samples ≤2 for 80% of samples ≤20 for 95% of samples FC >10 ≤3 - EC >10 ≤ 3 for 95% of samples ≤5 for 80% of samples ≤50 for 95% of samples Sewer Mining (SM) technology as a Distributed Intervention for Water-Energy-Materials in the Circular Economy: A Real World Demonstration in the Athens Plant Nursery Klio Monokrousou1, Christos Makropoulos1, Konstantinos Tsimnadis2, Georgios Katsouras3, Nikolaos Tsalas3 1. Department of Water Resources and Environmental Engineering, School of Civil Engineering, National Technical University of Athens, Heroon Polytechneiou 5, Zografou, 15780, Greece, kmonokrousou@gmail.com; cmakro@mail.ntua.gr 2. City of Athens, Department of Greenery and Urban Fauna, 5 Panag. Kanellopoulou, 11525 Athens, Greece, tsimnad@yahoo.gr 3. Athens Water Supply and Sewerage Company S. A (E.YD.A.P.) – Research and Development – 156 Oropou 11 str., 11146, Galatsi, Athens, Greece, gekats@eydap.gr; ntsal@eydap.gr Methodology Results The sewerage is extracted through two pumps that work alternately, from about four meters below the surface to fill in a buffer tank. The process starts when filtered wastewater enters a denitrification tank, where anaerobic microorganisms turn nitrates to nitrogen gas which naturally leaves the system. The denitrification tank communicates with a nitrification or aeration tank, where aerobic microorganisms turn reduced nitrogen compounds to nitrates. Subsequently, the biologically treated wastewater is transferred to the membrane tank and then the permeate passes through the UV disinfection unit and the final disinfected product flows naturally toward a storage tank to be reused mainly for irrigation purposes. The whole process is fully monitored through sensors and is automated using pneumatic actuated valves controlled by a PLC unit. The excess sludge produced from the SM unit along with the green and wood waste of the urban green spaces that end up in the Nursery, goes through a rapid composting process to produce on-site fertiliser. A heat exchanger and heat pump system recovers thermal energy from the wastewater to be reused for the technological processes of the c	poster
Ruta alternativa Barranco Jabalí Ruta alternativa Trincheras Sendero Acequias de Paulo y El Coto Usted está aquí Mapa propiedad del Instituto Geográfico Nacional El municipio alpujarreño de Pórtugos, ubicado en el macizo granadino de Sierra Nevada, destaca por sus diversas fuentes y manantiales que abastecen de agua una importante red de acequias históricas. Estos nacimientos de agua se enriquecen con los aportes nivales y permiten dotar al municipio de abundante agua. Estos sistemas de riego existen, al menos, desde época andalusí y han generado numerosos espacios de cultivo, pastos y han modelado el paisaje, haciendo de este, un espacio singular. En En el caso del sendero Acequias de Paulo y El Coto, podremos apreciar, transitando por el camino de servidumbre de paso de la acequia, parte de un sistema ancestral de manejo de agua. Estas acequias, toman las aguas del río Jabalí y recorren zonas de alta montaña, guiándola hasta puntos muy concretos donde se “carea”. Esto, signiöca la inöltración del agua en la tierra de manera artiöcial, para recogerla, en zonas más bajas, un tiempo después. A través de diferentes puntos de interés, podremos aprender sobre estos regadíos de alta montaña: la gestión y mantenimiento por parte de las comunidades de regantes, sus beneöcios ambientales, infraestructuras asociadas a estas y otros elementos con los que nos encontraremos a lo largo del recorrido (más información en el código QR). Visitaremos un espacio alterado por el ser humano tradicionalmente, pero que respeta de manera equilibrada y eöciente el medio en el que se encuentra. RECUERDE: Manténgase Evite hacer ruido Respete los bienes y Mantenga limpio No se permite No se permite la No se permite la No se permite la en los caminos propiedades privadas este entorno encender fuego recolección de plantas captura de animales recolección de fósiles 2 2 2 3 DATOS TÉCNICOS: Tipo de sendero: Semi-circular Distancia del recorrido: 7,3 km Desnivel acumulado de subida: 503 m Desnivel acumulado de bajada: 503 m Tiempo estimado del recorrido: 3 h y 10 min. Señalización de Sendero Local (SL) Acequia El Coto I Acequia de Paulo Panorámica de Pórtugos Sendero ACEQUIAS DE PAULO Y EL COTO (PÓRTUGOS) SL-A 386 Ayuntamiento de Pórtugos https://regadiohistorico.es	poster
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov ►Comparison of the HT-H295R screening data analyzed by ANOVA with the summary results available from the OECD validation study suggests that the HT-H295R assay predicted T and E2 effects well. ►The maxmMd is a reproducible and quantitative metric to determine the magnitude of chemical perturbation of steroidogenesis in HT-H295R, representing a data-driven option for evaluating lists of chemicals. ►The number of steroid hormone significantly perturbed in the HT-H295R assay does not indicate the magnitude of effect on steroidogenesis, whereas the maxmMd can differentiate strong and weak modulators of steroidogenesis. ►Selectivity scoring is a useful method to filter HT-H295R pathway positives for additional screening. ►Future work will include more comprehensive benchmarking of the maxmMd metric, and further adapting the HT- H295R kinetic model based on time-course experiments. We use Mahalanobis distance to quantify disruption of steroidogenesis across 11 steroid hormone measurements. Mahalanobis distance incorporates the effect size for each steroid hormone measure after adjusting for covariance between the steroid hormone measures. Evaluating Perturbation of In Vitro Steroidogenesis Using a High-throughput H295R Assay Derik E. Haggard1,2, Agnes L. Karmaus1,2,3, Matt T. Martin2,4, Richard S. Judson2, R. Woodrow Setzer2, Katie Paul Friedman2 1ORISE Postdoctoral Research Participant 2National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency 3Currently at Integrated Laboratory Systems, Inc 4Currently at Drug Safety Research and Development, Global Investigative Toxicology, Pfizer Derik E. Haggard l haggard.derik@epa.gov l 919-541-0745 Background: Endocrine disruption is a toxicity of both physiological and regulatory importance; as steroid hormones regulate reproduction, development, and other biological processes, it is a priority to identify chemicals that may interact with production of these hormones. A high-throughput H295R assay (HT-H295R) was developed as part of the U.S. EPA’s ToxCast program that includes measurement of 11 hormones across the steroid hormone biosynthesis pathway expressed in H295R cells, including progestagens, corticosteroids, androgens, and estrogens. HT-H295R Screening: 2012 chemicals in single concentration screening, 656 in concentration-response. Objectives: ►Demonstrate that the HT-H295R assay may be used to predict testosterone (T) and estradiol (E2) production via comparison of the 25 reference chemicals in the OECD-validated H295R assay. ►Develop a statistical analysis that integrates data from 11 steroid hormones into a single numeric value that indicates the magnitude of effect on steroidogenesis in the HT-H295R assay. ►Begin development of a pathway-based kinetic model of steroidogenesis in HT-H295R. This poster does not reflect US EPA policy. D.E.H. was supported by appointment to the Research Participation Program of the U.S. Environmental Protection Agency, Office of Research and Development, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. EPA. ►A total of 107 chemicals were replicated across multiple blocks; of these, 94 chemicals (87.9%) had concordant maxmMd pathway responses. ►maxmMd values were compared to the sum of steroid hormone hit counts, as measured by ANOVA. ►The maxmMd provides a quantitative indicator of activity that can distinguish chemicals that exert different magnitudes of effect on steroidogenesis but have the same hit count. Effect Sensitivity Specificity Accuracy Testosterone up 1.00 0.89 0.90 Testosterone dn 0.67 0.92 0.83 Estradiol up 0.75 0.83 0.80 Estradiol dn 0.80 1.00 0.95 Left: The residual covariances of many hormone measures in HT-H295R are highly correlated. Middle: Example of Euclidean distance for correlated	poster
Towards cell-inspired particle-based microrobots: Optimisation of the encapsulation of microparticles in lipid membranes Eugenia De Remigis1, Gaia Petrucci1, Elisa Roberti1, Dario Cecchi1, Hilda Gomez Bernal1, Elisa L. Petrocelli2, Jyoti Sharma1 , Francesco Bianciardi1 and Stefano Palagi1 1) The Biorobotics Institute, Scuola Superiore Sant’Anna, Pontedera (Pisa), Italy 2) Sapienza University of Rome (Rome), Italy Confinement of active matter can lead to the emergence of peculiar collective behaviour and interaction with the confining structure1,2. Encapsulating microscale active particles in flexible vesicles can be the basis for artificial active systems to study or emulate complex biological phenomena. ERC project CELLOIDS aims to employ this concept to fabricate soft, deformable and intelligent microrobots for medical applications, inspired by the amoeboid migration strategy of human leukocytes. Particle density has been shown to be crucial for the emergence of collective behaviour3,4. 1. Song, S. et al., J. Am. Chem. Soc. 144, 2022. 2. Vutukuri, H. R. et al., Nature 586, 2020. 3. Bricard, A. et al., Nature 503, 2013. 4. Buttinoni, I. et al., Phys. Rev. Lett. 110, 2013. 5. Pautot, S. et al., Langmuir 19, 2003. 6. Moga, A. et al., ChemBioChem 20, 2019. 7. Ghellab, S. E. et al., Biophys Chem 253, 2019. 8. NIST/SEMATECH e-Handbook of Statistical Methods, http://www.itl.nist.gov/div898/handbook/, accessed April 11, 2023. 9. Sakamoto, R. et al., Proceedings of the National Academy of Sciences 119, 2022. Icons from: Bioicons - high quality science illustrations Data analysis: ImageJ, Rstudio References Acknowledgements This work has been supported by the European Research Council under Grant Agreement No. 948590, project “CELLOIDS”. Further information Do not hesitate to contact us! eugenia.deremigis@santannapisa.it PI: stefano.palagi@santannapisa.it @MicroRobotLab @microrobot.lab Microscale Robotics Laboratory Optimization of microparticle encapsulation Objective 1: obtain controllable particle density Goal: design a bioinspired strategy to employ active microparticles as a propulsion system for ultra-deformable, autonomous microrobots. flexible membrane active core gives ultra- deformability and responsiveness allows for self- propulsion Fabrication of particle-loaded, phospholipid-based giant unilamellar vesicles (GUVs) by inverted emulsion method5,6 Critical process parameters • particle concentration in inner suspension • centrifugation acceleration and time Major issue: polydispersity in vesicle size and particle density Future directions Analysis: response surfaces7,8 Phase-contrast microscopy Motility of amoeboid model systems derives from the interaction with a confining environment9. Fabrication of GUVs encapsulating PS@Pt Janus microparticles A B Infiltration of empty/full GUVs in restrictive chambers Particle-loaded GUVs in confinement Objective 2: verify activity and stability GUVs + PS@Pt Janus microparticles in unconfined environment GUVs in hypertonic solution form protrusions, where active particles can move. Confinement of the GUV in an asymmetric restrictive environment Functionalisation of membrane phospholipids and Janus microparticles to induce contraction-based propulsion How to obtain directional movement of the GUV by exploiting the spontaneous behaviour of Janus microparticles? Activity Stability & Deformability contraction-based extension-based Response parameters • vesicle size • particle density combined Conclusions Objective 1: Results suggest that high particle concentration in the inner suspension helps obtain bigger and fuller GUVs. Long centrifugation time and high acceleration seem necessary to maximise GUV dimension; on the other hand, very high acceleration values could prove counterproductive for an efficient encapsulation. The optimal trade-off point is likely still outside the tested domain. hypertonic glucose solution 3% H2O2 in hypertonic glucose solution GUV suspension 1 2 3 no confineme	poster

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PosterSentry Training Data

Training dataset for PosterSentry — the multimodal scientific poster classifier used in the posters.science quality control pipeline.

Developed by the FAIR Data Innovations Hub at the California Medical Innovations Institute (CalMI²).

Dataset Description

Text extracted from real scientific poster PDFs and real non-poster documents — zero synthetic data. Every sample comes from an actual PDF downloaded from Zenodo or Figshare as part of the posters.science corpus.

Source Corpus

Sampled from a curated collection of 30,000+ classified scientific PDFs:

Category	Count	Platforms
Verified scientific posters	28,111	Zenodo, Figshare
Verified non-posters	2,036	Zenodo, Figshare
Corrupt/unreadable	58	—
Total classified	30,205	—

Non-posters include multi-page papers, conference proceedings, abstract books, newsletters, project proposals, and other documents mislabeled as "posters" in repository metadata.

Files

File	Description	Samples
`poster_sentry_train.ndjson`	Training data (text + labels)	3,606

Format

NDJSON (newline-delimited JSON) with text and label fields:

{"text": "TITLE: Effects of Temperature on Enzyme Kinetics\nAUTHORS: A. Smith...", "label": "poster"}
{"text": "Abstract. We present a novel approach to distributed computing...", "label": "non_poster"}

Label Distribution

Label	Count	Description
`poster`	1,803	Text from first page of verified single-page scientific posters
`non_poster`	1,803	Text from first page of verified multi-page documents

Classes are perfectly balanced (1:1 ratio).

Data Collection Methodology

Poster corpus assembly: 30K+ PDFs scraped from Zenodo and Figshare using the poster-repo-scraper
Classification: A Gradient Boosting classifier using PDF structural features (page count, physical dimensions, file size) separated posters from non-posters with F1 = 1.0 on held-out data
Separation: 2,036 non-posters moved to a separate directory; 28,111 verified posters retained
Text extraction: First page text extracted from each PDF using PyMuPDF (fitz), cleaned and truncated to 4,000 characters
Balanced sampling: 1,803 samples per class (limited by the smaller non-poster class)

Related Resources

Resource	Link
PosterSentry model	fairdataihub/poster-sentry
Llama-3.1-8B-Poster-Extraction	fairdataihub/Llama-3.1-8B-Poster-Extraction
poster2json library	PyPI · GitHub
poster-json-schema	GitHub
Platform	posters.science

Usage

Train PosterSentry from this data

pip install poster-sentry
python scripts/train_poster_sentry.py --n-per-class 2000

Load directly with HuggingFace datasets

from datasets import load_dataset

ds = load_dataset("fairdataihub/poster-sentry-training-data")
print(ds["train"][0])
# {"text": "TITLE: ...", "label": "poster"}

Use for PubGuard doc_type training

The poster texts in this dataset are also used by PubGuard to train its poster document-type classification head.

Citation

@dataset{poster_sentry_data_2026,
  title = {PosterSentry Training Data: Real Scientific Poster Text Corpus},
  author = {O'Neill, James and Soundarajan, Sanjay and Portillo, Dorian and Patel, Bhavesh},
  year = {2026},
  url = {https://huggingface.co/datasets/fairdataihub/poster-sentry-training-data},
  note = {Part of the posters.science initiative}
}

License

MIT License — See LICENSE for details.

Acknowledgments

FAIR Data Innovations Hub at California Medical Innovations Institute (CalMI²)
posters.science platform
HuggingFace for dataset hosting infrastructure
Funded by The Navigation Fund (10.71707/rk36-9x79) — "Poster Sharing and Discovery Made Easy"

Downloads last month: 10

Size of downloaded dataset files:

9.45 MB

Size of the auto-converted Parquet files:

5.48 MB

Number of rows:

3,606