gene
stringlengths 2
16
| uniprot_id
stringlengths 6
10
⌀ | protein_name
stringlengths 5
112
⌀ | protein_function
stringlengths 9
12.5k
⌀ | protein_domains
stringlengths 2
5.58k
| protein_interactions
stringlengths 2
4.35k
| pathways
stringlengths 11
43.4k
| go_mf
stringlengths 2
1.83k
| go_bp
stringlengths 2
10.3k
| go_cc
stringlengths 2
1.57k
|
|---|---|---|---|---|---|---|---|---|---|
A1BG
|
P04217
|
Alpha-1B-glycoprotein
| null |
['Ig-like V-type 1' 'Ig-like V-type 2' 'Ig-like V-type 3'
'Ig-like V-type 4' 'Ig-like V-type 5']
|
[]
|
['GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS' 'GOCC_BLOOD_MICROPARTICLE'
'GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX'
'GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE' 'GOCC_FICOLIN_1_RICH_GRANULE'
'GOCC_FICOLIN_1_RICH_GRANULE_LUMEN' 'GOCC_PLATELET_ALPHA_GRANULE'
'GOCC_PLATELET_ALPHA_GRANULE_LUMEN' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VESICLE_LUMEN' 'REACTOME_HEMOSTASIS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NEUTROPHIL_DEGRANULATION'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2']
|
[]
|
['GO:0002764 immune response-regulating signaling pathway']
|
['GO:0072562 blood microparticle', 'GO:0070062 extracellular exosome', 'GO:0005576 extracellular region', 'GO:0005615 extracellular space', 'GO:1904813 ficolin-1-rich granule lumen', 'GO:0005886 plasma membrane', 'GO:0031093 platelet alpha granule lumen', 'GO:0034774 secretory granule lumen']
|
A1CF
|
Q9NQ94
|
APOBEC1 complementation factor
|
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay
|
['RRM 1' 'RRM 2' 'RRM 3']
|
['ACTMAP' 'CYSRT1' 'DOK3' 'ECM1' 'EIF4G1' 'FHL2' 'FHL3' 'HSPB2' 'KLHDC7B'
'KRT31' 'KRT34' 'METTL27' 'OIP5' 'PLEKHG4' 'POGZ' 'REL' 'RIMBP3' 'SPMIP6'
'TRAF1' 'CAVIN2']
|
['GOBP_BASE_CONVERSION_OR_SUBSTITUTION_EDITING'
'GOBP_CHROMOSOMAL_5_METHYLCYTOSINE_DNA_DEMETHYLATION_PATHWAY'
'GOBP_CYTIDINE_TO_URIDINE_EDITING' 'GOBP_DNA_METABOLIC_PROCESS'
'GOBP_EMBRYO_IMPLANTATION' 'GOBP_INTRACELLULAR_MRNA_LOCALIZATION'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS' 'GOBP_MRNA_CATABOLIC_PROCESS'
'GOBP_MRNA_METABOLIC_PROCESS' 'GOBP_MRNA_MODIFICATION'
'GOBP_MRNA_PROCESSING' 'GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_NEGATIVE_REGULATION_OF_MRNA_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MRNA_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS'
'GOBP_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_NUCLEIC_ACID_CATABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_GENE_EXPRESSION'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_PROTEIN_STABILIZATION' 'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_MRNA_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_MRNA_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_NUCLEAR_TRANSCRIBED_MRNA_CATABOLIC_PROCESS_NONSENSE_MEDIATED_DECAY'
'GOBP_REGULATION_OF_PROTEIN_STABILITY' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RNA_LOCALIZATION' 'GOBP_RNA_MODIFICATION' 'GOBP_RNA_PROCESSING'
'GOCC_APOLIPOPROTEIN_B_MRNA_EDITING_ENZYME_COMPLEX'
'GOCC_CATALYTIC_COMPLEX' 'GOCC_MRNA_EDITING_COMPLEX'
'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOMF_DOUBLE_STRANDED_RNA_BINDING'
'GOMF_ENZYME_SUBSTRATE_ADAPTOR_ACTIVITY'
'GOMF_MOLECULAR_ADAPTOR_ACTIVITY' 'GOMF_MRNA_BINDING'
'GOMF_SINGLE_STRANDED_RNA_BINDING' 'IL21_UP.V1_DN' 'IL2_UP.V1_DN'
'REACTOME_METABOLISM_OF_RNA' 'REACTOME_MRNA_EDITING'
'REACTOME_MRNA_EDITING_C_TO_U_CONVERSION']
|
['GO:0140767 enzyme-substrate adaptor activity', 'GO:0003729 mRNA binding', 'GO:0003727 single-stranded RNA binding']
|
['GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway', 'GO:0016554 cytidine to uridine editing', 'GO:0007566 embryo implantation', 'GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression', 'GO:0016556 mRNA modification', 'GO:0006397 mRNA processing', 'GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay', 'GO:0050821 protein stabilization']
|
['GO:0030895 apolipoprotein B mRNA editing enzyme complex', 'GO:0005737 cytoplasm', 'GO:0005783 endoplasmic reticulum', 'GO:0045293 mRNA editing complex', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus']
|
A2M
|
P01023
|
Alpha-2-macroglobulin
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
|
[]
|
['ABHD17C' 'AP2B1' 'ATP5IF1' 'BRK1' 'CLEC2B' 'COPS3' 'CSF2' 'CTNNB1'
'CYFIP1' 'DAZ3' 'DDX20' 'DNTTIP1' 'ERAL1' 'FOXA2' 'FOXR1' 'FZD4' 'H2AZ1'
'H3C12' 'HOXC4' 'IQSEC1' 'KAT5' 'KAT5' 'KRTAP10-7' 'KRTAP8-1' 'LHX6'
'LNX1' 'LYN' 'MGARP' 'MKL1' 'MNDA' 'MRFAP1' 'OTUB1' 'OTUD7B' 'PARK7'
'PIAS1' 'PIK3R1' 'PRDM1' 'RAB38' 'RNF112' 'RNF183' 'S100B' 'SMN2'
'SPATA12' 'STUB1' 'STX11' 'STX19' 'SYK' 'TEAD1' 'TRIM69' 'TWIST2' 'TXN'
'UTP14A' 'VPS29' 'VPS33A' 'ZNF366' 'Ppif']
|
['ATF2_S_UP.V1_DN' 'BMI1_DN_MEL18_DN.V1_DN' 'CYCLIN_D1_KE_.V1_DN'
'EGFR_UP.V1_UP' 'GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_COMPLEMENT_ACTIVATION' 'GOBP_COMPLEMENT_ACTIVATION_LECTIN_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT' 'GOBP_HUMORAL_IMMUNE_RESPONSE'
'GOBP_IMMUNE_EFFECTOR_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_COMPLEMENT_ACTIVATION'
'GOBP_NEGATIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_COMPLEMENT_ACTIVATION'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_HUMORAL_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_EFFECTOR_PROCESS'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS' 'GOBP_STEM_CELL_DIFFERENTIATION'
'GOCC_BLOOD_MICROPARTICLE'
'GOCC_COLLAGEN_CONTAINING_EXTRACELLULAR_MATRIX'
'GOCC_EXTERNAL_ENCAPSULATING_STRUCTURE' 'GOCC_PLATELET_ALPHA_GRANULE'
'GOCC_PLATELET_ALPHA_GRANULE_LUMEN' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VESICLE_LUMEN'
'GOMF_CALCIUM_DEPENDENT_PROTEIN_BINDING' 'GOMF_CHEMOKINE_BINDING'
'GOMF_CYTOKINE_BINDING' 'GOMF_C_X_C_CHEMOKINE_BINDING'
'GOMF_ENDOPEPTIDASE_ACTIVITY' 'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_ENZYME_INHIBITOR_ACTIVITY' 'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_GROWTH_FACTOR_BINDING' 'GOMF_INTERLEUKIN_1_BINDING'
'GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_PROTEASE_BINDING' 'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_TUMOR_NECROSIS_FACTOR_BINDING'
'HALLMARK_COAGULATION' 'HALLMARK_IL6_JAK_STAT3_SIGNALING'
'KEGG_COMPLEMENT_AND_COAGULATION_CASCADES' 'KRAS.300_UP.V1_UP'
'KRAS.50_UP.V1_UP' 'KRAS.600.LUNG.BREAST_UP.V1_UP' 'KRAS.600_UP.V1_UP'
'KRAS.BREAST_UP.V1_UP' 'KRAS.KIDNEY_UP.V1_UP' 'KRAS.LUNG.BREAST_UP.V1_UP'
'MEL18_DN.V1_DN' 'PID_IL6_7_PATHWAY'
'REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX'
'REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION'
'REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE'
'REACTOME_HDL_ASSEMBLY' 'REACTOME_HEMOSTASIS'
'REACTOME_INTRINSIC_PATHWAY_OF_FIBRIN_CLOT_FORMATION'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'STK33_NOMO_UP']
|
['GO:0048306 calcium-dependent protein binding', 'GO:0004866 endopeptidase inhibitor activity', 'GO:0019899 enzyme binding', 'GO:0019838 growth factor binding', 'GO:0019966 interleukin-1 binding', 'GO:0019959 interleukin-8 binding', 'GO:0002020 protease binding', 'GO:0004867 serine-type endopeptidase inhibitor activity', 'GO:0005102 signaling receptor binding', 'GO:0043120 tumor necrosis factor binding']
|
['GO:0001869 negative regulation of complement activation, lectin pathway', 'GO:0048863 stem cell differentiation']
|
['GO:0072562 blood microparticle', 'GO:0070062 extracellular exosome', 'GO:0031012 extracellular matrix', 'GO:0005576 extracellular region', 'GO:0005615 extracellular space', 'GO:0031093 platelet alpha granule lumen']
|
A2ML1
|
A8K2U0
|
Alpha-2-macroglobulin-like protein 1
|
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases
|
[]
|
[]
|
['GOBP_PROTEOLYSIS' 'GOBP_REGULATION_OF_CATALYTIC_ACTIVITY'
'GOBP_REGULATION_OF_ENDOPEPTIDASE_ACTIVITY'
'GOBP_REGULATION_OF_HYDROLASE_ACTIVITY'
'GOBP_REGULATION_OF_MOLECULAR_FUNCTION'
'GOBP_REGULATION_OF_PEPTIDASE_ACTIVITY'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEOLYSIS' 'GOMF_ENDOPEPTIDASE_ACTIVITY'
'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY' 'GOMF_ENZYME_INHIBITOR_ACTIVITY'
'GOMF_ENZYME_REGULATOR_ACTIVITY'
'GOMF_MOLECULAR_FUNCTION_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_INHIBITOR_ACTIVITY' 'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY']
|
['GO:0030414 peptidase inhibitor activity', 'GO:0004867 serine-type endopeptidase inhibitor activity']
|
['GO:0052548 regulation of endopeptidase activity']
|
['GO:0070062 extracellular exosome', 'GO:0005615 extracellular space']
|
A3GALT2
|
U3KPV4
|
Alpha-1,3-galactosyltransferase 2
|
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures
|
[]
|
[]
|
['GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_METABOLIC_PROCESS'
'GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_GLYCOSYLATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_APPARATUS_SUBCOMPARTMENT' 'GOCC_GOLGI_CISTERNA'
'GOCC_GOLGI_CISTERNA_MEMBRANE' 'GOCC_GOLGI_STACK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOMF_GALACTOSYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY'
'WP_GANGLIO_SPHINGOLIPID_METABOLISM' 'WP_GLYCOSPHINGOLIPID_METABOLISM'
'WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES']
|
['GO:0016757 glycosyltransferase activity', 'GO:0046872 metal ion binding', 'GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity']
|
['GO:0005975 carbohydrate metabolic process', 'GO:0006688 glycosphingolipid biosynthetic process']
|
['GO:0005794 Golgi apparatus', 'GO:0032580 Golgi cisterna membrane', 'GO:0031982 vesicle']
|
A4GALT
|
Q9NPC4
|
Lactosylceramide 4-alpha-galactosyltransferase
|
Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system (PubMed:10747952, PubMed:10748143, PubMed:22965229, PubMed:26773500, PubMed:29572228, PubMed:33460651). Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77 (PubMed:10748143, PubMed:10747952, PubMed:26773500, PubMed:29572228, PubMed:22965229). Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity) (PubMed:29572228). Synthesizes P1 glycan epitope (alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-GlcNAc-R) by transferring a galactose moiety to paragloboside nLc4 or to complex-type N-glycans (PubMed:26773500, PubMed:29572228, PubMed:33460651). Generates the rare NOR1 and NOR2 antigens which carry a Gal(alpha1->4)GalNAc terminal moiety and are both derived from Gb4Cer precursor (PubMed:22965229, PubMed:26773500, PubMed:33460651). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143)
|
[]
|
[]
|
['AKT_UP_MTOR_DN.V1_UP' 'E2F1_UP.V1_DN' 'ESC_J1_UP_EARLY.V1_UP'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION'
'GOBP_GLYCOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_GALACTOSYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_TOXIC_SUBSTANCE_BINDING' 'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY'
'KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBO_SERIES'
'REACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS'
'REACTOME_GLYCOSPHINGOLIPID_METABOLISM' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_SPHINGOLIPID_METABOLISM' 'WNT_UP.V1_UP'
'WP_GLYCOSPHINGOLIPID_METABOLISM'
'WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES']
|
['GO:0008378 galactosyltransferase activity', 'GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity', 'GO:0015643 toxic substance binding']
|
['GO:0001576 globoside biosynthetic process', 'GO:0006688 glycosphingolipid biosynthetic process', 'GO:0007009 plasma membrane organization']
|
['GO:0000139 Golgi membrane', 'GO:0016020 membrane']
|
A4GNT
|
Q9UNA3
|
Alpha-1,4-N-acetylglucosaminyltransferase
|
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) residues from UDP-N-acetyl-alpha-D-glucosamine donnors to beta (1->4)-linked or beta-(1->3)-linked galactose residues on O-glycans like core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity)
|
[]
|
[]
|
['GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CARBOHYDRATE_METABOLIC_PROCESS'
'GOBP_EPITHELIAL_CELL_PROLIFERATION'
'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION'
'GOBP_O_GLYCAN_PROCESSING' 'GOBP_PROTEIN_O_LINKED_GLYCOSYLATION'
'GOBP_REGULATION_OF_CELL_POPULATION_PROLIFERATION'
'GOBP_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_ACETYLGLUCOSAMINYLTRANSFERASE_ACTIVITY'
'GOMF_GLYCOSYLTRANSFERASE_ACTIVITY' 'GOMF_HEXOSYLTRANSFERASE_ACTIVITY'
'GOMF_UDP_GLYCOSYLTRANSFERASE_ACTIVITY' 'IL21_UP.V1_DN' 'IL2_UP.V1_DN'
'REACTOME_O_LINKED_GLYCOSYLATION'
'REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS'
'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION']
|
['GO:0008375 acetylglucosaminyltransferase activity']
|
['GO:0005975 carbohydrate metabolic process', 'GO:0050673 epithelial cell proliferation', 'GO:0009101 glycoprotein biosynthetic process', 'GO:0050680 negative regulation of epithelial cell proliferation', 'GO:0006493 protein O-linked glycosylation', 'GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine']
|
['GO:0000139 Golgi membrane', 'GO:0016020 membrane']
|
AAAS
|
Q9NRG9
|
Aladin
|
Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606)
|
[]
|
[]
|
['CAMP_UP.V1_UP' 'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_BEHAVIOR'
'GOBP_CELL_CYCLE' 'GOBP_CELL_CYCLE_PROCESS'
'GOBP_CHROMOSOME_ORGANIZATION' 'GOBP_CHROMOSOME_SEGREGATION'
'GOBP_COGNITION' 'GOBP_CYTOSKELETON_ORGANIZATION'
'GOBP_DEVELOPMENTAL_GROWTH' 'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_ESTABLISHMENT_OF_RNA_LOCALIZATION' 'GOBP_FERTILIZATION'
'GOBP_GLUTATHIONE_METABOLIC_PROCESS' 'GOBP_GROWTH'
'GOBP_INTRACELLULAR_TRANSPORT' 'GOBP_LEARNING'
'GOBP_MEMBRANELESS_ORGANELLE_ASSEMBLY' 'GOBP_MICROTUBULE_BASED_PROCESS'
'GOBP_MICROTUBULE_BUNDLE_FORMATION'
'GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION'
'GOBP_MICROTUBULE_CYTOSKELETON_ORGANIZATION_INVOLVED_IN_MITOSIS'
'GOBP_MITOTIC_CELL_CYCLE' 'GOBP_MITOTIC_CELL_CYCLE_PROCESS'
'GOBP_MITOTIC_NUCLEAR_DIVISION'
'GOBP_MITOTIC_SISTER_CHROMATID_SEGREGATION'
'GOBP_MITOTIC_SPINDLE_ASSEMBLY' 'GOBP_MITOTIC_SPINDLE_ORGANIZATION'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_MRNA_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISM_GROWTH' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_NUCLEAR_CHROMOSOME_SEGREGATION'
'GOBP_NUCLEAR_TRANSPORT' 'GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_ORGANELLE_FISSION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RESPONSE_TO_OXIDATIVE_STRESS' 'GOBP_RNA_LOCALIZATION'
'GOBP_SEXUAL_REPRODUCTION' 'GOBP_SISTER_CHROMATID_SEGREGATION'
'GOBP_SPINDLE_ASSEMBLY' 'GOBP_SPINDLE_ORGANIZATION'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_CENTROSOME'
'GOCC_MICROTUBULE_CYTOSKELETON' 'GOCC_MICROTUBULE_ORGANIZING_CENTER'
'GOCC_MITOTIC_SPINDLE' 'GOCC_NUCLEAR_ENVELOPE' 'GOCC_NUCLEAR_MEMBRANE'
'GOCC_NUCLEAR_PORE' 'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_SPINDLE' 'GOCC_SPINDLE_POLE'
'HALLMARK_DNA_REPAIR' 'KRAS.600.LUNG.BREAST_UP.V1_DN' 'RB_DN.V1_UP'
'REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES'
'REACTOME_CELLULAR_RESPONSES_TO_STIMULI'
'REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS' 'REACTOME_CELL_CYCLE'
'REACTOME_CELL_CYCLE_MITOTIC'
'REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS'
'REACTOME_GENE_SILENCING_BY_RNA' 'REACTOME_GLUCOSE_METABOLISM'
'REACTOME_HCMV_EARLY_EVENTS' 'REACTOME_HCMV_INFECTION'
'REACTOME_HCMV_LATE_EVENTS' 'REACTOME_HIV_INFECTION'
'REACTOME_HIV_LIFE_CYCLE' 'REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS'
'REACTOME_INFECTIOUS_DISEASE' 'REACTOME_INFLUENZA_INFECTION'
'REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS'
'REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS'
'REACTOME_INTERFERON_SIGNALING' 'REACTOME_ISG15_ANTIVIRAL_MECHANISM'
'REACTOME_METABOLISM_OF_CARBOHYDRATES_AND_CARBOHYDRATE_DERIVATIVES'
'REACTOME_METABOLISM_OF_RNA' 'REACTOME_MITOTIC_PROPHASE'
'REACTOME_M_PHASE' 'REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS'
'REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN'
'REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN'
'REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY'
'REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA'
'REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN'
'REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE'
'REACTOME_RHOA_GTPASE_CYCLE' 'REACTOME_RHO_GTPASE_CYCLE'
'REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES'
'REACTOME_SARS_COV_2_HOST_INTERACTIONS' 'REACTOME_SARS_COV_2_INFECTION'
'REACTOME_SARS_COV_INFECTIONS'
'REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3'
'REACTOME_SLC_TRANSPORTER_DISORDERS' 'REACTOME_SNRNP_ASSEMBLY'
'REACTOME_SUMOYLATION'
'REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS'
'REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS'
'REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS'
'REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS'
'REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS'
'REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS'
'REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM'
'REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA'
'REACTOME_TRNA_PROCESSING' 'REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS'
'REACTOME_VIRAL_INFECTION_PATHWAYS'
'REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS' 'SRC_UP.V1_UP'
'WP_PRADERWILLI_AND_ANGELMAN_SYNDROME']
|
[]
|
['GO:0009566 fertilization', 'GO:0006749 glutathione metabolic process', 'GO:0007612 learning', 'GO:0001578 microtubule bundle formation', 'GO:0090307 mitotic spindle assembly', 'GO:0051028 mRNA transport', 'GO:0035264 multicellular organism growth', 'GO:0006913 nucleocytoplasmic transport', 'GO:0015031 protein transport', 'GO:0046822 regulation of nucleocytoplasmic transport', 'GO:0006979 response to oxidative stress']
|
['GO:0005813 centrosome', 'GO:0005829 cytosol', 'GO:0016020 membrane', 'GO:0072686 mitotic spindle', 'GO:0005635 nuclear envelope', 'GO:0031965 nuclear membrane', 'GO:0005643 nuclear pore', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus', 'GO:0097229 sperm end piece', 'GO:0000922 spindle pole']
|
AACS
|
Q86V21
|
Acetoacetyl-CoA synthetase
|
Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity)
|
[]
|
['CMTM5']
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_CELL_CELL_SIGNALING'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FATTY_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_FATTY_ACID_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY'
'GOBP_HORMONE_TRANSPORT' 'GOBP_INSULIN_SECRETION'
'GOBP_KETONE_BODY_BIOSYNTHETIC_PROCESS'
'GOBP_KETONE_BODY_METABOLIC_PROCESS' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_PEPTIDE_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_SECRETION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOMF_ACID_THIOL_LIGASE_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_COA_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY' 'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS'
'KEGG_BUTANOATE_METABOLISM' 'REACTOME_KETONE_BODY_METABOLISM'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_SYNTHESIS_OF_KETONE_BODIES']
|
['GO:0030729 acetoacetate-CoA ligase activity', 'GO:0005524 ATP binding']
|
['GO:0006631 fatty acid metabolic process', 'GO:0046951 ketone body biosynthetic process', 'GO:0032024 positive regulation of insulin secretion']
|
['GO:0005829 cytosol']
|
AADAC
|
P22760
|
Arylacetamide deacetylase
|
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
|
[]
|
['APPBP2']
|
['ATF2_S_UP.V1_DN' 'ATF2_UP.V1_DN'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_GLYCEROLIPID_CATABOLIC_PROCESS'
'GOBP_GLYCEROLIPID_METABOLIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_NEUTRAL_LIPID_CATABOLIC_PROCESS'
'GOBP_NEUTRAL_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRIGLYCERIDE_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_TRIGLYCERIDE_CATABOLIC_PROCESS'
'GOBP_TRIGLYCERIDE_METABOLIC_PROCESS' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY' 'GOMF_DEACETYLASE_ACTIVITY'
'GOMF_DEACYLASE_ACTIVITY' 'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS'
'GOMF_LIPASE_ACTIVITY' 'GOMF_SERINE_HYDROLASE_ACTIVITY'
'GOMF_TRIACYLGLYCEROL_LIPASE_ACTIVITY' 'KRAS.KIDNEY_UP.V1_DN'
'REACTOME_BIOLOGICAL_OXIDATIONS'
'REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS' 'SRC_UP.V1_UP']
|
['GO:0003824 catalytic activity', 'GO:0019213 deacetylase activity', 'GO:0016298 lipase activity', 'GO:0017171 serine hydrolase activity', 'GO:0004806 triacylglycerol lipase activity']
|
['GO:0006629 lipid metabolic process', 'GO:0010898 positive regulation of triglyceride catabolic process', 'GO:0006805 xenobiotic metabolic process']
|
['GO:0005789 endoplasmic reticulum membrane']
|
AADACL2
|
Q6P093
|
Arylacetamide deacetylase-like 2
| null |
[]
|
[]
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0005576 extracellular region', 'GO:0016020 membrane']
|
AADACL3
|
Q5VUY0
|
Arylacetamide deacetylase-like 3
| null |
[]
|
[]
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0016020 membrane']
|
AADACL4
|
Q5VUY2
|
Arylacetamide deacetylase-like 4
| null |
[]
|
[]
|
['GOMF_CARBOXYLIC_ESTER_HYDROLASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ESTER_BONDS']
|
['GO:0052689 carboxylic ester hydrolase activity']
|
[]
|
['GO:0016020 membrane']
|
AADAT
|
Q8N5Z0
|
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
|
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro)
|
[]
|
[]
|
['GOBP_2_OXOGLUTARATE_METABOLIC_PROCESS'
'GOBP_ACETYL_COA_METABOLIC_PROCESS' 'GOBP_ACYL_COA_METABOLIC_PROCESS'
'GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_AMIDE_CATABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_BENZENE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_GLUTAMATE_METABOLIC_PROCESS'
'GOBP_GLUTAMINE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_KETONE_METABOLIC_PROCESS' 'GOBP_KYNURENINE_METABOLIC_PROCESS'
'GOBP_LYSINE_METABOLIC_PROCESS' 'GOBP_L_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_MITOCHONDRIAL_MATRIX'
'GOCC_MITOCHONDRION' 'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSAMINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS'
'GOMF_VITAMIN_B6_BINDING' 'GOMF_VITAMIN_BINDING'
'HALLMARK_FATTY_ACID_METABOLISM' 'KEGG_LYSINE_DEGRADATION'
'KEGG_TRYPTOPHAN_METABOLISM' 'REACTOME_LYSINE_CATABOLISM'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES'
'REACTOME_TRYPTOPHAN_CATABOLISM' 'WP_ADHD_AND_AUTISM_ASD_PATHWAYS'
'WP_IDO_METABOLIC_PATHWAY'
'WP_KYNURENINE_PATHWAY_AND_LINKS_TO_CELL_SENESCENCE'
'WP_METABOLIC_EPILEPTIC_DISORDERS'
'WP_TRYPTOPHAN_CATABOLISM_LEADING_TO_NAD_PRODUCTION'
'WP_TRYPTOPHAN_METABOLISM']
|
['GO:0047536 2-aminoadipate transaminase activity', 'GO:0047958 glycine:2-oxoglutarate aminotransferase activity', 'GO:0047315 kynurenine-glyoxylate transaminase activity', 'GO:0016212 kynurenine-oxoglutarate transaminase activity', 'GO:0050094 methionine-glyoxylate transaminase activity', 'GO:0042803 protein homodimerization activity', 'GO:0030170 pyridoxal phosphate binding']
|
['GO:0006103 2-oxoglutarate metabolic process', 'GO:1901605 alpha-amino acid metabolic process', 'GO:0006536 glutamate metabolic process', 'GO:0070189 kynurenine metabolic process', 'GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine']
|
['GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
AAGAB
|
Q6PD74
|
Alpha- and gamma-adaptin-binding protein p34
|
May be involved in endocytic recycling of growth factor receptors such as EGFR
|
[]
|
['AP1G1' 'AP1S3' 'AP1S3' 'AP2A2' 'AP2S1' 'HEATR1']
|
['GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_PROTEIN_TRANSPORT'
'GOCC_NUCLEAR_BODY' 'GOCC_NUCLEAR_SPECK' 'PDGF_ERK_DN.V1_UP']
|
[]
|
['GO:0015031 protein transport']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0016607 nuclear speck']
|
AAK1
|
Q2M2I8
|
AP2-associated protein kinase 1
|
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:17494869, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124)
|
['Protein kinase']
|
['ATP13A2']
|
['GOBP_CLATHRIN_DEPENDENT_ENDOCYTOSIS' 'GOBP_ENDOCYTOSIS'
'GOBP_IMPORT_INTO_CELL' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_NOTCH_SIGNALING_PATHWAY' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PHOSPHORYLATION'
'GOBP_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING' 'GOBP_PRESYNAPTIC_ENDOCYTOSIS'
'GOBP_PROTEIN_STABILIZATION' 'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CLATHRIN_DEPENDENT_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_PROTEIN_STABILITY'
'GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE' 'GOCC_AXON'
'GOCC_CELL_LEADING_EDGE' 'GOCC_CLATHRIN_COATED_PIT'
'GOCC_CLATHRIN_COATED_VESICLE' 'GOCC_COATED_VESICLE' 'GOCC_DISTAL_AXON'
'GOCC_NEURON_PROJECTION' 'GOCC_NEURON_PROJECTION_TERMINUS'
'GOCC_PRESYNAPSE' 'GOCC_SYNAPSE' 'GOCC_TERMINAL_BOUTON'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AP_2_ADAPTOR_COMPLEX_BINDING'
'GOMF_KINASE_ACTIVITY' 'GOMF_NOTCH_BINDING'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING' 'GOMF_PROTEIN_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'RAF_UP.V1_UP'
'REACTOME_CARGO_RECOGNITION_FOR_CLATHRIN_MEDIATED_ENDOCYTOSIS'
'REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS' 'REACTOME_MEMBRANE_TRAFFICKING'
'REACTOME_VESICLE_MEDIATED_TRANSPORT'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES']
|
['GO:0035612 AP-2 adaptor complex binding', 'GO:0005524 ATP binding', 'GO:0005112 Notch binding', 'GO:0106310 protein serine kinase activity', 'GO:0004674 protein serine/threonine kinase activity']
|
['GO:0061024 membrane organization', 'GO:0045747 positive regulation of Notch signaling pathway', 'GO:0140238 presynaptic endocytosis', 'GO:0006468 protein phosphorylation', 'GO:0050821 protein stabilization', 'GO:2000369 regulation of clathrin-dependent endocytosis', 'GO:0032880 regulation of protein localization']
|
['GO:0031252 cell leading edge', 'GO:0005905 clathrin-coated pit', 'GO:0030136 clathrin-coated vesicle', 'GO:0005829 cytosol', 'GO:0005886 plasma membrane', 'GO:0098793 presynapse', 'GO:0043195 terminal bouton']
|
AAMDC
|
Q9H7C9
|
Mth938 domain-containing protein
|
May play a role in preadipocyte differentiation and adipogenesis
|
[]
|
['ACY3' 'APP' 'ATXN3' 'DNM2' 'GDAP1' 'GORASP2' 'HTT' 'VPS9D1']
|
['GOBP_APOPTOTIC_PROCESS' 'GOBP_FAT_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_FAT_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH']
|
[]
|
['GO:0043066 negative regulation of apoptotic process', 'GO:0045600 positive regulation of fat cell differentiation', 'GO:0045944 positive regulation of transcription by RNA polymerase II', 'GO:0006366 transcription by RNA polymerase II']
|
['GO:0005737 cytoplasm']
|
AAMP
|
Q13685
|
Angio-associated migratory cell protein
|
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway
|
[]
|
['AEN' 'AEN']
|
['GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_BLOOD_VESSEL_MORPHOGENESIS' 'GOBP_CELL_MOTILITY'
'GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT' 'GOBP_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_LOCOMOTION' 'GOBP_MUSCLE_CELL_MIGRATION'
'GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_POSITIVE_REGULATION_OF_LOCOMOTION'
'GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION'
'GOBP_REGULATION_OF_LOCOMOTION' 'GOBP_SMOOTH_MUSCLE_CELL_MIGRATION'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_TUBE_MORPHOGENESIS'
'GOBP_VASCULATURE_DEVELOPMENT' 'GOCC_CELL_SURFACE'
'GOCC_INTERCELLULAR_BRIDGE' 'GOCC_MICROTUBULE_CYTOSKELETON'
'GOMF_GLYCOSAMINOGLYCAN_BINDING' 'GOMF_HEPARIN_BINDING'
'GOMF_SULFUR_COMPOUND_BINDING' 'REACTOME_HEMOSTASIS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NOD1_2_SIGNALING_PATHWAY'
'REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS'
'REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION'
'REACTOME_SIGNALING_BY_EGFR'
'REACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES'
'REACTOME_SIGNALING_BY_VEGF' 'REACTOME_SIGNAL_AMPLIFICATION'
'REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR'
'WP_NUCLEOTIDEBINDING_OLIGOMERIZATION_DOMAIN_NOD_PATHWAY']
|
['GO:0008201 heparin binding']
|
['GO:0001525 angiogenesis', 'GO:0030154 cell differentiation', 'GO:0010595 positive regulation of endothelial cell migration', 'GO:0014909 smooth muscle cell migration']
|
['GO:0009986 cell surface', 'GO:0005829 cytosol', 'GO:0045171 intercellular bridge', 'GO:0015630 microtubule cytoskeleton', 'GO:0005886 plasma membrane']
|
AANAT
|
Q16613
|
Serotonin N-acetyltransferase
|
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin
|
['N-acetyltransferase']
|
['BHLHE40' 'EIF4E3' 'GRB10' 'KRTAP8-1' 'MDFI']
|
['GOBP_AMIDE_BIOSYNTHETIC_PROCESS' 'GOBP_AMIDE_METABOLIC_PROCESS'
'GOBP_AMINE_BIOSYNTHETIC_PROCESS' 'GOBP_AMINE_METABOLIC_PROCESS'
'GOBP_CELLULAR_RESPONSE_TO_CAMP'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CIRCADIAN_RHYTHM' 'GOBP_HORMONE_BIOSYNTHETIC_PROCESS'
'GOBP_HORMONE_METABOLIC_PROCESS' 'GOBP_INDOLALKYLAMINE_METABOLIC_PROCESS'
'GOBP_INDOLE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS'
'GOBP_INDOLE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_ACETYLATION'
'GOBP_N_TERMINAL_PROTEIN_AMINO_ACID_MODIFICATION' 'GOBP_PHOTOPERIODISM'
'GOBP_PROTEIN_ACETYLATION' 'GOBP_PROTEIN_ACYLATION'
'GOBP_PROTEIN_MATURATION' 'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ALCOHOL'
'GOBP_RESPONSE_TO_CALCIUM_ION' 'GOBP_RESPONSE_TO_CAMP'
'GOBP_RESPONSE_TO_COPPER_ION' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_CORTICOSTERONE' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_INSULIN'
'GOBP_RESPONSE_TO_KETONE' 'GOBP_RESPONSE_TO_LIGHT_STIMULUS'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_MINERALOCORTICOID' 'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_ORGANOPHOSPHORUS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_PEPTIDE_HORMONE' 'GOBP_RESPONSE_TO_PROSTAGLANDIN'
'GOBP_RESPONSE_TO_PROSTAGLANDIN_E'
'GOBP_RESPONSE_TO_PURINE_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_RADIATION' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_ZINC_ION' 'GOBP_RHYTHMIC_PROCESS'
'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM' 'GOMF_14_3_3_PROTEIN_BINDING'
'GOMF_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_ACYLTRANSFERASE_ACTIVITY'
'GOMF_ACYLTRANSFERASE_ACTIVITY_TRANSFERRING_GROUPS_OTHER_THAN_AMINO_ACYL_GROUPS'
'GOMF_N_ACETYLTRANSFERASE_ACTIVITY' 'GOMF_N_ACYLTRANSFERASE_ACTIVITY'
'KEGG_TRYPTOPHAN_METABOLISM' 'PRC1_BMI_UP.V1_DN'
'REACTOME_METABOLISM_OF_AMINE_DERIVED_HORMONES'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES'
'REACTOME_SEROTONIN_AND_MELATONIN_BIOSYNTHESIS'
'WP_ADHD_AND_AUTISM_ASD_PATHWAYS' 'WP_BIOGENIC_AMINE_SYNTHESIS'
'WP_BIOSYNTHESIS_AND_REGENERATION_OF_TETRAHYDROBIOPTERIN_AND_CATABOLISM_OF_PHENYLALANINE'
'WP_CIRCADIAN_RHYTHM_GENES' 'WP_MELATONIN_METABOLISM_AND_EFFECTS'
'WP_TRYPTOPHAN_METABOLISM']
|
['GO:0071889 14-3-3 protein binding', 'GO:0004059 aralkylamine N-acetyltransferase activity', 'GO:0004060 arylamine N-acetyltransferase activity']
|
['GO:0071320 cellular response to cAMP', 'GO:0007623 circadian rhythm', 'GO:0046219 indolalkylamine biosynthetic process', 'GO:0030187 melatonin biosynthetic process', 'GO:0006474 N-terminal protein amino acid acetylation', 'GO:0009648 photoperiodism', 'GO:0051592 response to calcium ion', 'GO:0046688 response to copper ion', 'GO:0051412 response to corticosterone', 'GO:0034097 response to cytokine', 'GO:0032868 response to insulin', 'GO:0009416 response to light stimulus', 'GO:0034695 response to prostaglandin E', 'GO:0010043 response to zinc ion']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0048471 perinuclear region of cytoplasm']
|
AAR2
|
Q9Y312
|
Protein AAR2 homolog
|
Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing
|
[]
|
[]
|
['GOBP_MRNA_METABOLIC_PROCESS' 'GOBP_MRNA_PROCESSING'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION'
'GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS' 'GOBP_RNA_PROCESSING'
'GOBP_RNA_SPLICING' 'GOBP_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS'
'GOBP_SPLICEOSOMAL_SNRNP_ASSEMBLY'
'GOBP_SPLICEOSOMAL_TRI_SNRNP_COMPLEX_ASSEMBLY'
'GOCC_NUCLEAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SMALL_NUCLEAR_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SM_LIKE_PROTEIN_FAMILY_COMPLEX' 'GOCC_SPLICEOSOMAL_COMPLEX'
'GOCC_U5_SNRNP' 'WP_CILIARY_LANDSCAPE']
|
[]
|
['GO:0000244 spliceosomal tri-snRNP complex assembly']
|
['GO:0005681 spliceosomal complex', 'GO:0005682 U5 snRNP']
|
AARD
|
Q4LEZ3
|
Alanine- and arginine-rich domain-containing protein
| null |
[]
|
['CENPQ' 'CEP57' 'GRIPAP1' 'KIAA0753' 'KRT24' 'KRT27' 'LMO4' 'MAGEB4'
'NTAQ1' 'STX1A' 'STX2' 'STX5' 'TFIP11' 'TSGA10' 'VPS37C']
|
['GCNP_SHH_UP_LATE.V1_UP' 'GOBP_RESPONSE_TO_KETONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_TESTOSTERONE' 'WNT_UP.V1_DN']
|
[]
|
['GO:0033574 response to testosterone']
|
[]
|
AARS1
|
P49588
|
Alanine--tRNA ligase, cytoplasmic
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451)
|
[]
|
[]
|
['CAMP_UP.V1_UP'
'GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_APOPTOTIC_PROCESS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CEREBELLAR_CORTEX_DEVELOPMENT'
'GOBP_CEREBELLAR_PURKINJE_CELL_LAYER_DEVELOPMENT'
'GOBP_CYTOPLASMIC_TRANSLATION'
'GOBP_CYTOPLASMIC_TRANSLATIONAL_ELONGATION' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HINDBRAIN_DEVELOPMENT' 'GOBP_HIPPO_SIGNALING'
'GOBP_METENCEPHALON_DEVELOPMENT'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NEUROMUSCULAR_PROCESS'
'GOBP_NEUROMUSCULAR_PROCESS_CONTROLLING_BALANCE'
'GOBP_NEURON_APOPTOTIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_HIPPO_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION'
'GOBP_REGULATION_OF_HIPPO_SIGNALING'
'GOBP_REGULATION_OF_NEURON_APOPTOTIC_PROCESS'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_REGULATION_OF_TRANSLATION'
'GOBP_REGULATION_OF_TRANSLATIONAL_ELONGATION'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_RNA_MODIFICATION'
'GOBP_RNA_PROCESSING' 'GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR'
'GOBP_TRANSLATION' 'GOBP_TRANSLATIONAL_ELONGATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOBP_TRNA_MODIFICATION'
'GOBP_TRNA_PROCESSING' 'GOCC_MITOCHONDRION'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_AMINO_ACID_BINDING'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS'
'GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS' 'GOMF_TRNA_BINDING'
'HALLMARK_ALLOGRAFT_REJECTION' 'KEGG_AMINOACYL_TRNA_BIOSYNTHESIS'
'RB_P107_DN.V1_DN' 'REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION'
'REACTOME_TRANSLATION' 'REACTOME_TRNA_AMINOACYLATION' 'WP_IL18_SIGNALING']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0016597 amino acid binding', 'GO:0002161 aminoacyl-tRNA deacylase activity', 'GO:0005524 ATP binding', 'GO:0141207 peptide lactyltransferase (ATP-dependent) activity', 'GO:0002196 Ser-tRNA(Ala) deacylase activity', 'GO:0000049 tRNA binding', 'GO:0008270 zinc ion binding']
|
['GO:0006419 alanyl-tRNA aminoacylation', 'GO:0021680 cerebellar Purkinje cell layer development', 'GO:0043524 negative regulation of neuron apoptotic process', 'GO:1901797 negative regulation of signal transduction by p53 class mediator', 'GO:0050885 neuromuscular process controlling balance', 'GO:0051402 neuron apoptotic process', 'GO:0035332 positive regulation of hippo signaling', 'GO:0140018 regulation of cytoplasmic translational fidelity', 'GO:0006418 tRNA aminoacylation for protein translation', 'GO:0006400 tRNA modification', 'GO:0008033 tRNA processing']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0070062 extracellular exosome', 'GO:0016020 membrane', 'GO:0005634 nucleus']
|
AARS2
|
Q5JTZ9
|
Alanine--tRNA ligase, mitochondrial
|
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:21549344). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as CGAS (PubMed:39322678). Acts as an inhibitor of cGAS/STING signaling by catalyzing lactylation of CGAS, preventing the formation of liquid-like droplets in which CGAS is activated (PubMed:39322678)
|
[]
|
['EHHADH' 'PTPA']
|
['GOBP_ACTIVATION_OF_IMMUNE_RESPONSE'
'GOBP_ACTIVATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CGAS_STING_SIGNALING_PATHWAY'
'GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM'
'GOBP_DEFENSE_RESPONSE_TO_SYMBIONT'
'GOBP_IMMUNE_RESPONSE_REGULATING_SIGNALING_PATHWAY'
'GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_MITOCHONDRIAL_GENE_EXPRESSION'
'GOBP_MITOCHONDRIAL_RNA_METABOLIC_PROCESS'
'GOBP_MITOCHONDRIAL_TRANSLATION'
'GOBP_NEGATIVE_REGULATION_OF_CGAS_STING_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_DEFENSE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_INNATE_IMMUNE_RESPONSE'
'GOBP_REGULATION_OF_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_TRANSLATION'
'GOBP_TRNA_AMINOACYLATION_FOR_MITOCHONDRIAL_PROTEIN_TRANSLATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOCC_MITOCHONDRION'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS'
'GOMF_LIGASE_ACTIVITY_FORMING_PHOSPHORIC_ESTER_BONDS' 'GOMF_TRNA_BINDING'
'KEGG_AMINOACYL_TRNA_BIOSYNTHESIS'
'REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION' 'REACTOME_TRANSLATION'
'REACTOME_TRNA_AMINOACYLATION' 'WP_PRIMARY_OVARIAN_INSUFFICIENCY']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0002161 aminoacyl-tRNA deacylase activity', 'GO:0005524 ATP binding', 'GO:0141207 peptide lactyltransferase (ATP-dependent) activity', 'GO:0000049 tRNA binding', 'GO:0008270 zinc ion binding']
|
['GO:0070143 mitochondrial alanyl-tRNA aminoacylation', 'GO:0160049 negative regulation of cGAS/STING signaling pathway']
|
['GO:0005739 mitochondrion']
|
AARSD1
|
Q9BTE6
|
Alanyl-tRNA editing protein Aarsd1
|
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala)
|
[]
|
['ARID4B' 'DYNLT1' 'FAAP100' 'MLF1' 'SPANXN3' 'TRIM45' 'ZMYND19' 'ZNF185']
|
['GOBP_AMINOACYL_TRNA_METABOLISM_INVOLVED_IN_TRANSLATIONAL_FIDELITY'
'GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRANSLATIONAL_FIDELITY' 'GOBP_TRANSLATION'
'GOBP_TRNA_METABOLIC_PROCESS' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_AMINOACYL_TRNA_DEACYLASE_ACTIVITY'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_NUCLEIC_ACID'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_A_TRNA'
'GOMF_CATALYTIC_ACTIVITY_ACTING_ON_RNA' 'GOMF_LIGASE_ACTIVITY'
'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_OXYGEN_BONDS']
|
['GO:0004813 alanine-tRNA ligase activity', 'GO:0005524 ATP binding', 'GO:0046872 metal ion binding', 'GO:0003676 nucleic acid binding', 'GO:0002196 Ser-tRNA(Ala) deacylase activity']
|
['GO:0006419 alanyl-tRNA aminoacylation', 'GO:0006450 regulation of translational fidelity']
|
['GO:0005737 cytoplasm', 'GO:0005634 nucleus']
|
AASDH
|
Q4L235
|
Beta-alanine-activating enzyme
|
Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA
|
['Carrier']
|
[]
|
['GOBP_AMINO_ACID_ACTIVATION' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_NONRIBOSOMAL_PEPTIDE_BIOSYNTHETIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_PEPTIDE_BIOSYNTHETIC_PROCESS'
'GOBP_PEPTIDE_METABOLIC_PROCESS' 'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOMF_ACID_THIOL_LIGASE_ACTIVITY' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_LIGASE_ACTIVITY' 'GOMF_LIGASE_ACTIVITY_FORMING_CARBON_SULFUR_BONDS'
'KEGG_LYSINE_DEGRADATION']
|
['GO:0005524 ATP binding', 'GO:0016874 ligase activity']
|
['GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process', 'GO:0019482 beta-alanine metabolic process', 'GO:0006631 fatty acid metabolic process']
|
[]
|
AASDHPPT
|
Q9NRN7
|
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
|
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN
|
[]
|
['CRX' 'EFHC2' 'SIAH1' 'TRAF2' 'USP22' 'USP22']
|
['ERBB2_UP.V1_DN' 'GOBP_10_FORMYLTETRAHYDROFOLATE_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_DICARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_DICARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_FOLIC_ACID_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_MODIFIED_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_PANTOTHENATE_METABOLIC_PROCESS' 'GOBP_PROTEIN_MATURATION'
'GOBP_PTERIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS'
'GOBP_PTERIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_TETRAHYDROFOLATE_METABOLIC_PROCESS'
'GOBP_VITAMIN_METABOLIC_PROCESS'
'GOBP_WATER_SOLUBLE_VITAMIN_METABOLIC_PROCESS'
'GOMF_MAGNESIUM_ION_BINDING'
'GOMF_PHOSPHOTRANSFERASE_ACTIVITY_FOR_OTHER_SUBSTITUTED_PHOSPHATE_GROUPS'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'KEGG_LYSINE_DEGRADATION' 'REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS'
'REACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS'
'REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM']
|
['GO:0008897 holo-[acyl-carrier-protein] synthase activity', 'GO:0000287 magnesium ion binding']
|
['GO:0009258 10-formyltetrahydrofolate catabolic process', 'GO:0019878 lysine biosynthetic process via aminoadipic acid', 'GO:0015939 pantothenate metabolic process', 'GO:0051604 protein maturation']
|
['GO:0005829 cytosol', 'GO:0070062 extracellular exosome']
|
AASS
|
Q9UDR5
|
Alpha-aminoadipic semialdehyde synthase, mitochondrial
|
Bifunctional enzyme that catalyzes the first two steps in lysine degradation
|
[]
|
[]
|
['GOBP_ACETYL_COA_METABOLIC_PROCESS' 'GOBP_ACYL_COA_METABOLIC_PROCESS'
'GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS' 'GOBP_AMIDE_CATABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_ASPARTATE_FAMILY_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_LYSINE_METABOLIC_PROCESS' 'GOBP_L_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RNA_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II'
'GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_PURINE_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SULFUR_COMPOUND_METABOLIC_PROCESS' 'GOCC_MITOCHONDRIAL_MATRIX'
'GOCC_MITOCHONDRION' 'GOMF_HISTONE_BINDING'
'GOMF_MOLECULAR_ADAPTOR_ACTIVITY' 'GOMF_OXIDOREDUCTASE_ACTIVITY'
'GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS'
'GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_NH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR'
'GOMF_TRANSCRIPTION_COREGULATOR_ACTIVITY'
'GOMF_TRANSCRIPTION_COREPRESSOR_ACTIVITY'
'GOMF_TRANSCRIPTION_REGULATOR_ACTIVITY' 'KEGG_LYSINE_DEGRADATION'
'REACTOME_LYSINE_CATABOLISM'
'REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES' 'VEGF_A_UP.V1_DN'
'WP_METABOLIC_EPILEPTIC_DISORDERS']
|
['GO:0042393 histone binding', 'GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity', 'GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity', 'GO:0047130 saccharopine dehydrogenase (NADP+, L-lysine-forming) activity', 'GO:0004753 saccharopine dehydrogenase activity', 'GO:0003714 transcription corepressor activity']
|
['GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine', 'GO:0019878 lysine biosynthetic process via aminoadipic acid', 'GO:0006554 lysine catabolic process', 'GO:0000122 negative regulation of transcription by RNA polymerase II']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion', 'GO:0005634 nucleus']
|
AATF
|
Q9NY61
|
Protein AATF
|
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date
|
[]
|
['APP' 'ATM' 'CHEK2' 'KAT2A' 'MNS1' 'NGDN' 'PIK3R1' 'POLR2J' 'RAC1'
'RBBP8' 'RELA' 'SP1' 'TADA2A' 'TADA2B' 'TADA3' 'Myl12a']
|
['CAMP_UP.V1_UP' 'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_APOPTOTIC_PROCESS' 'GOBP_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS' 'GOBP_CELL_ADHESION'
'GOBP_CELL_CYCLE' 'GOBP_CELL_DIVISION' 'GOBP_EMBRYONIC_CLEAVAGE'
'GOBP_EMBRYO_DEVELOPMENT' 'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS' 'GOBP_MITOTIC_CELL_CYCLE'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY'
'GOBP_REGULATION_OF_CELL_CYCLE'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_MITOTIC_CELL_CYCLE'
'GOBP_REGULATION_OF_PROGRAMMED_CELL_DEATH'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS'
'GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS' 'GOBP_RIBOSOME_BIOGENESIS'
'GOCC_NUCLEOLUS' 'GOCC_PRERIBOSOME' 'GOCC_RIBONUCLEOPROTEIN_COMPLEX'
'GOCC_SMALL_SUBUNIT_PROCESSOME' 'GOCC_TRANSCRIPTION_REGULATOR_COMPLEX'
'GOMF_LEUCINE_ZIPPER_DOMAIN_BINDING' 'GOMF_LRR_DOMAIN_BINDING'
'GOMF_PROTEIN_DOMAIN_SPECIFIC_BINDING' 'PID_RB_1PATHWAY'
'REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE'
'REACTOME_DEATH_RECEPTOR_SIGNALING'
'REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK'
'REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING'
'WP_17Q12_COPY_NUMBER_VARIATION_SYNDROME']
|
['GO:0043522 leucine zipper domain binding', 'GO:0003723 RNA binding']
|
['GO:0007155 cell adhesion', 'GO:0040016 embryonic cleavage', 'GO:0042985 negative regulation of amyloid precursor protein biosynthetic process', 'GO:2001234 negative regulation of apoptotic signaling pathway', 'GO:0007346 regulation of mitotic cell cycle', 'GO:0042274 ribosomal small subunit biogenesis']
|
['GO:0005737 cytoplasm', 'GO:0005730 nucleolus', 'GO:0005654 nucleoplasm', 'GO:0005634 nucleus', 'GO:0032040 small-subunit processome', 'GO:0005667 transcription regulator complex']
|
AATK
|
Q6ZMQ8
|
Serine/threonine-protein kinase LMTK1
|
May be involved in neuronal differentiation
|
['Protein kinase']
|
['PPP1CA' 'PPP1CC' 'TEPSIN' 'CDK5R1' 'CDK5R1']
|
['GOBP_APOPTOTIC_PROCESS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_HEAD_DEVELOPMENT' 'GOBP_NEURON_APOPTOTIC_PROCESS'
'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM' 'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_KINASE_ACTIVITY' 'GOMF_PROTEIN_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY'
'GOMF_PROTEIN_TYROSINE_KINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_PHOSPHORUS_CONTAINING_GROUPS'
'IL21_UP.V1_UP' 'IL2_UP.V1_UP' 'KRAS.AMP.LUNG_UP.V1_DN'
'KRAS.PROSTATE_UP.V1_DN' 'PRC1_BMI_UP.V1_UP' 'PRC2_EED_DN.V1_UP'
'PRC2_EZH2_UP.V1_UP' 'PRC2_SUZ12_UP.V1_UP']
|
['GO:0005524 ATP binding', 'GO:0106310 protein serine kinase activity', 'GO:0004674 protein serine/threonine kinase activity', 'GO:0004713 protein tyrosine kinase activity']
|
['GO:0007420 brain development', 'GO:0051402 neuron apoptotic process']
|
['GO:0012505 endomembrane system', 'GO:0016020 membrane', 'GO:0048471 perinuclear region of cytoplasm']
|
ABAT
|
P80404
|
4-aminobutyrate aminotransferase, mitochondrial
|
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine (By similarity)
|
[]
|
[]
|
['GOBP_ACIDIC_AMINO_ACID_TRANSPORT' 'GOBP_ACID_SECRETION'
'GOBP_AMIDE_TRANSPORT' 'GOBP_AMINE_METABOLIC_PROCESS'
'GOBP_AMINE_TRANSPORT' 'GOBP_AMINO_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_AMINO_ACID_CATABOLIC_PROCESS' 'GOBP_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_AMINO_ACID_TRANSPORT' 'GOBP_BEHAVIOR'
'GOBP_C4_DICARBOXYLATE_TRANSPORT' 'GOBP_CATECHOLAMINE_SECRETION'
'GOBP_CATECHOLAMINE_TRANSPORT'
'GOBP_CATECHOL_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CHEMICAL_SYNAPTIC_TRANSMISSION_POSTSYNAPTIC'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_COPULATION'
'GOBP_DICARBOXYLIC_ACID_TRANSPORT' 'GOBP_DOPAMINE_METABOLIC_PROCESS'
'GOBP_DOPAMINE_SECRETION' 'GOBP_DOPAMINE_TRANSPORT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION' 'GOBP_EXPLORATION_BEHAVIOR'
'GOBP_EXPORT_FROM_CELL'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_METABOLIC_PROCESS'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_SECRETION'
'GOBP_GAMMA_AMINOBUTYRIC_ACID_TRANSPORT' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HEAT_GENERATION' 'GOBP_HINDBRAIN_DEVELOPMENT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_HORMONE_TRANSPORT'
'GOBP_INHIBITORY_POSTSYNAPTIC_POTENTIAL' 'GOBP_INSULIN_SECRETION'
'GOBP_LOCOMOTORY_BEHAVIOR' 'GOBP_MATING_BEHAVIOR'
'GOBP_METENCEPHALON_DEVELOPMENT'
'GOBP_MODULATION_OF_INHIBITORY_POSTSYNAPTIC_POTENTIAL'
'GOBP_MONOAMINE_TRANSPORT' 'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_REPRODUCTIVE_PROCESS'
'GOBP_MUSCLE_CONTRACTION' 'GOBP_MUSCLE_SYSTEM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMINE_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_NEGATIVE_REGULATION_OF_CATECHOLAMINE_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_SECRETION'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_CATABOLIC_PROCESS'
'GOBP_NON_PROTEINOGENIC_AMINO_ACID_METABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHENOL_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMINE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMINE_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_HEAT_GENERATION'
'GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_INSULIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION'
'GOBP_POSITIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PEPTIDE_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_UTERINE_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_PROLACTIN_SECRETION'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_AMINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMINO_ACID_TRANSPORT'
'GOBP_REGULATION_OF_BLOOD_PRESSURE'
'GOBP_REGULATION_OF_CATECHOLAMINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATECHOLAMINE_SECRETION'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_DOPAMINE_SECRETION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_GAMMA_AMINOBUTYRIC_ACID_SECRETION'
'GOBP_REGULATION_OF_HEAT_GENERATION' 'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_MUSCLE_CONTRACTION'
'GOBP_REGULATION_OF_MUSCLE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REPRODUCTIVE_BEHAVIOR' 'GOBP_REPRODUCTIVE_PROCESS'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ALCOHOL'
'GOBP_RESPONSE_TO_ALKALOID' 'GOBP_RESPONSE_TO_COCAINE'
'GOBP_RESPONSE_TO_ETHANOL' 'GOBP_RESPONSE_TO_IRON_ION'
'GOBP_RESPONSE_TO_METAL_ION' 'GOBP_RESPONSE_TO_NICOTINE'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_LEVELS' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECRETION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_SMOOTH_MUSCLE_CONTRACTION'
'GOBP_SYNAPTIC_SIGNALING' 'GOBP_TEMPERATURE_HOMEOSTASIS'
'GOBP_UTERINE_SMOOTH_MUSCLE_CONTRACTION' 'GOCC_CATALYTIC_COMPLEX'
'GOCC_INTRACELLULAR_PROTEIN_CONTAINING_COMPLEX'
'GOCC_MITOCHONDRIAL_MATRIX' 'GOCC_MITOCHONDRION'
'GOCC_TRANSFERASE_COMPLEX' 'GOMF_METAL_CLUSTER_BINDING'
'GOMF_TRANSAMINASE_ACTIVITY'
'GOMF_TRANSFERASE_ACTIVITY_TRANSFERRING_NITROGENOUS_GROUPS'
'GOMF_VITAMIN_B6_BINDING' 'GOMF_VITAMIN_BINDING'
'HALLMARK_ESTROGEN_RESPONSE_EARLY' 'HALLMARK_P53_PATHWAY'
'KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM'
'KEGG_BETA_ALANINE_METABOLISM' 'KEGG_BUTANOATE_METABOLISM'
'KEGG_PROPANOATE_METABOLISM'
'KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION' 'RAF_UP.V1_DN'
'RB_P107_DN.V1_UP'
'REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION'
'REACTOME_NEURONAL_SYSTEM' 'REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE'
'REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES'
'WP_ADHD_AND_AUTISM_ASD_PATHWAYS' 'WP_ALANINE_AND_ASPARTATE_METABOLISM'
'WP_FRAGILE_X_SYNDROME' 'WP_GABA_METABOLISM_AKA_GHB'
'WP_GABA_RECEPTOR_SIGNALING'
'WP_PYRIMIDINE_METABOLISM_AND_RELATED_DISEASES'
'WP_VALPROIC_ACID_PATHWAY']
|
['GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity', 'GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity', 'GO:0042802 identical protein binding', 'GO:0051536 iron-sulfur cluster binding', 'GO:0046872 metal ion binding', 'GO:0030170 pyridoxal phosphate binding', 'GO:0032145 succinate-semialdehyde dehydrogenase binding']
|
['GO:0021549 cerebellum development', 'GO:0007620 copulation', 'GO:0035640 exploration behavior', 'GO:0009449 gamma-aminobutyric acid biosynthetic process', 'GO:0009450 gamma-aminobutyric acid catabolic process', 'GO:0009448 gamma-aminobutyric acid metabolic process', 'GO:0007626 locomotory behavior', 'GO:0045776 negative regulation of blood pressure', 'GO:0033602 negative regulation of dopamine secretion', 'GO:0014053 negative regulation of gamma-aminobutyric acid secretion', 'GO:0050877 nervous system process', 'GO:1904450 positive regulation of aspartate secretion', 'GO:0045964 positive regulation of dopamine metabolic process', 'GO:0031652 positive regulation of heat generation', 'GO:0097151 positive regulation of inhibitory postsynaptic potential', 'GO:0032024 positive regulation of insulin secretion', 'GO:1902722 positive regulation of prolactin secretion', 'GO:0070474 positive regulation of uterine smooth muscle contraction', 'GO:0042220 response to cocaine', 'GO:0045471 response to ethanol', 'GO:0001666 response to hypoxia', 'GO:0010039 response to iron ion', 'GO:0035094 response to nicotine', 'GO:0009410 response to xenobiotic stimulus']
|
['GO:0032144 4-aminobutyrate transaminase complex', 'GO:0005759 mitochondrial matrix', 'GO:0005739 mitochondrion']
|
ABCA1
|
O95477
|
Phospholipid-transporting ATPase ABCA1
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981, PubMed:35974019). Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981, PubMed:35974019). Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain (PubMed:35974019)
|
['ABC transporter 1' 'ABC transporter 2']
|
['ABCA12' 'APOA1' 'ARHGEF11' 'CANX' 'CDC42' 'DLG1' 'DLG2' 'DLG3' 'DLG4'
'LIN7B' 'MAGI2' 'MPDZ' 'PATJ' 'SCRIB' 'SNTA1' 'SNTB1' 'SNTB2' 'STX12']
|
['BIOCARTA_FXR_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'BMI1_DN.V1_UP'
'BMI1_DN_MEL18_DN.V1_UP'
'GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_ALCOHOL_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_CDC42_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_CELLULAR_RESPONSE_TO_ALCOHOL'
'GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_CHOLESTEROL' 'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_LIPOPROTEIN_PARTICLE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_RETINOIC_ACID'
'GOBP_CELLULAR_RESPONSE_TO_STEROL'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CELL_CELL_SIGNALING' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_CHOLESTEROL_STORAGE' 'GOBP_ENDOCYTOSIS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION' 'GOBP_ENDOSOMAL_TRANSPORT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FOAM_CELL_DIFFERENTIATION'
'GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_STEROL_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_LIPOPROTEIN_METABOLIC_PROCESS' 'GOBP_LYTIC_VACUOLE_ORGANIZATION'
'GOBP_MEMBRANE_INVAGINATION' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_STORAGE'
'GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_NUTRIENT_STORAGE'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHAGOCYTOSIS' 'GOBP_PHAGOCYTOSIS_ENGULFMENT'
'GOBP_PHOSPHOLIPID_EFFLUX' 'GOBP_PHOSPHOLIPID_HOMEOSTASIS'
'GOBP_PHOSPHOLIPID_TRANSLOCATION' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_PLATELET_DENSE_GRANULE_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT' 'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATION_OF_CDC42_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_STORAGE'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_STORAGE' 'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_RHO_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_BACTERIUM'
'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_FLUID_SHEAR_STRESS'
'GOBP_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_LIPOPROTEIN_PARTICLE'
'GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_RESPONSE_TO_NITROGEN_COMPOUND' 'GOBP_RESPONSE_TO_NUTRIENT'
'GOBP_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_RETINOIC_ACID' 'GOBP_RESPONSE_TO_STEROL'
'GOBP_RESPONSE_TO_VITAMIN' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_RHO_PROTEIN_SIGNAL_TRANSDUCTION'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS' 'GOBP_SECRETION'
'GOBP_SECRETORY_GRANULE_ORGANIZATION' 'GOBP_SIGNAL_RELEASE'
'GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_SPHINGOLIPID_TRANSLOCATION'
'GOBP_STEROID_METABOLIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VACUOLE_ORGANIZATION' 'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_ORGANIZATION' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_CELL_SURFACE'
'GOCC_ENDOCYTIC_VESICLE' 'GOCC_ENDOSOME'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_GOLGI_APPARATUS'
'GOCC_MEMBRANE_MICRODOMAIN'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_SUBCOMPARTMENT' 'GOCC_PERINUCLEAR_REGION_OF_CYTOPLASM'
'GOCC_PHAGOCYTIC_VESICLE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_ALCOHOL_BINDING'
'GOMF_APOLIPOPROTEIN_A_I_BINDING' 'GOMF_APOLIPOPROTEIN_BINDING'
'GOMF_ATPASE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CARGO_RECEPTOR_ACTIVITY' 'GOMF_CHOLESTEROL_BINDING'
'GOMF_CHOLESTEROL_TRANSFER_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_GTPASE_BINDING' 'GOMF_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_BINDING'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_LIPID_BINDING'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MACROMOLECULE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_BINDING'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY' 'GOMF_PHOSPHOLIPID_BINDING'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING'
'GOMF_PROTEIN_LIPID_COMPLEX_BINDING'
'GOMF_PROTEIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_TRANSPORTER_ACTIVITY'
'GOMF_QUATERNARY_AMMONIUM_GROUP_BINDING'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_SNARE_BINDING'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_STEROID_BINDING'
'GOMF_STEROL_BINDING' 'GOMF_STEROL_TRANSFER_ACTIVITY'
'GOMF_SYNTAXIN_BINDING' 'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_ADIPOGENESIS'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_INFLAMMATORY_RESPONSE'
'HALLMARK_PROTEIN_SECRETION' 'HALLMARK_TNFA_SIGNALING_VIA_NFKB'
'KEGG_ABC_TRANSPORTERS' 'MTOR_UP.V1_DN' 'NOTCH_DN.V1_DN'
'PID_RXR_VDR_PATHWAY' 'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_HDL_ASSEMBLY' 'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING'
'REACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY'
'REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY_REMODELING_AND_CLEARANCE'
'REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA'
'REACTOME_SIGNALING_BY_NUCLEAR_RECEPTORS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'STK33_NOMO_UP' 'STK33_UP'
'WNT_UP.V1_DN' 'WP_2Q37_COPY_NUMBER_VARIATION_SYNDROME'
'WP_CAMKK2_PATHWAY' 'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_CHOLESTEROL_METABOLISM'
'WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS'
'WP_EFFECT_OF_OMEGA3_PUFA_ON_HUNTINGTONS_DISEASE_PATHWAYS'
'WP_ENTEROCYTE_CHOLESTEROL_METABOLISM'
'WP_FATTY_ACID_AND_LIPOPROTEIN_TRANSPORT_IN_HEPATOCYTES'
'WP_FOLATE_METABOLISM'
'WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_SELENIUM_MICRONUTRIENT_NETWORK'
'WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS'
'WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION'
'WP_UROTENSINIIMEDIATED_SIGNALING' 'WP_VITAMIN_B12_METABOLISM']
|
['GO:0140359 ABC-type transporter activity', 'GO:0034186 apolipoprotein A-I binding', 'GO:0034188 apolipoprotein A-I receptor activity', 'GO:0034185 apolipoprotein binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0051117 ATPase binding', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015485 cholesterol binding', 'GO:0120020 cholesterol transfer activity', 'GO:0140328 floppase activity', 'GO:0008035 high-density lipoprotein particle binding', 'GO:0031210 phosphatidylcholine binding', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090556 phosphatidylserine floppase activity', 'GO:0005548 phospholipid transporter activity', 'GO:0008320 protein transmembrane transporter activity', 'GO:0005102 signaling receptor binding', 'GO:0031267 small GTPase binding', 'GO:0046623 sphingolipid floppase activity', 'GO:0019905 syntaxin binding']
|
['GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway', 'GO:0071397 cellular response to cholesterol', 'GO:0071345 cellular response to cytokine stimulus', 'GO:0071222 cellular response to lipopolysaccharide', 'GO:0071404 cellular response to low-density lipoprotein particle stimulus', 'GO:0071300 cellular response to retinoic acid', 'GO:0071466 cellular response to xenobiotic stimulus', 'GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0008203 cholesterol metabolic process', 'GO:0016197 endosomal transport', 'GO:0140115 export across plasma membrane', 'GO:0007186 G protein-coupled receptor signaling pathway', 'GO:0034380 high-density lipoprotein particle assembly', 'GO:0032367 intracellular cholesterol transport', 'GO:0042158 lipoprotein biosynthetic process', 'GO:0007040 lysosome organization', 'GO:0010887 negative regulation of cholesterol storage', 'GO:0010745 negative regulation of macrophage derived foam cell differentiation', 'GO:0002790 peptide secretion', 'GO:0006911 phagocytosis, engulfment', 'GO:0033700 phospholipid efflux', 'GO:0055091 phospholipid homeostasis', 'GO:0045332 phospholipid translocation', 'GO:0060155 platelet dense granule organization', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0090108 positive regulation of high-density lipoprotein particle assembly', 'GO:0009306 protein secretion', 'GO:0071806 protein transmembrane transport', 'GO:0032489 regulation of Cdc42 protein signal transduction', 'GO:0090107 regulation of high-density lipoprotein particle assembly', 'GO:0034616 response to laminar fluid shear stress', 'GO:0033552 response to vitamin B3', 'GO:0043691 reverse cholesterol transport', 'GO:0023061 signal release']
|
['GO:0016323 basolateral plasma membrane', 'GO:0030139 endocytic vesicle', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005768 endosome', 'GO:0009897 external side of plasma membrane', 'GO:0005794 Golgi apparatus', 'GO:0097708 intracellular vesicle', 'GO:0045121 membrane raft', 'GO:0048471 perinuclear region of cytoplasm', 'GO:0045335 phagocytic vesicle', 'GO:0005886 plasma membrane']
|
ABCA10
|
Q8WWZ4
|
ATP-binding cassette sub-family A member 10
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['GOBP_LIPID_LOCALIZATION' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0006869 lipid transport']
|
['GO:0005886 plasma membrane']
|
ABCA11P
| null | null | null |
[]
|
[]
|
['WP_VITAMIN_D_RECEPTOR_PATHWAY']
|
[]
|
[]
|
[]
|
ABCA12
|
Q86UK0
|
Glucosylceramide transporter ABCA12
|
Transports lipids such as glucosylceramides from the outer to the inner leaflet of lamellar granules (LGs) membrane, whereby the lipids are finally transported to the keratinocyte periphery via the trans-Golgi network and LGs and released to the apical surface of the granular keratinocytes to form lipid lamellae in the stratum corneum of the epidermis, which is essential for skin barrier function (PubMed:16007253, PubMed:20869849). In the meantime, participates in the transport of the lamellar granules-associated proteolytic enzymes, in turn regulates desquamation and keratinocyte differentiation (PubMed:19179616). Furthermore, is essential for the regulation of cellular cholesterol homeostasis by regulating ABCA1-dependent cholesterol efflux from macrophages through interaction with NR1H2 and ABCA1 (By similarity). Plays pleiotropic roles in regulating glucose stimulated insulin secretion from beta cells, regulating the morphology and fusion of insulin granules, lipid raft abundance and the actin cytoskeleton (By similarity). Also involved in lung surfactant biogenesis (By similarity)
|
['ABC transporter 1' 'ABC transporter 2']
|
['ABCA1']
|
['GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_ANIMAL_ORGAN_MORPHOGENESIS' 'GOBP_CARBOHYDRATE_HOMEOSTASIS'
'GOBP_CELLULAR_HOMEOSTASIS'
'GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELL_ADHESION' 'GOBP_CELL_CELL_ADHESION' 'GOBP_CELL_CELL_SIGNALING'
'GOBP_CERAMIDE_METABOLIC_PROCESS' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_DELAMINATION'
'GOBP_EPIDERMAL_CELL_DIFFERENTIATION' 'GOBP_EPIDERMIS_DEVELOPMENT'
'GOBP_EPITHELIAL_CELL_DEVELOPMENT' 'GOBP_EPITHELIAL_CELL_DIFFERENTIATION'
'GOBP_EPITHELIUM_DEVELOPMENT'
'GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_ESTABLISHMENT_OF_SKIN_BARRIER' 'GOBP_EXOCYTOSIS'
'GOBP_EXPORT_FROM_CELL' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_HORMONE_TRANSPORT' 'GOBP_INSULIN_SECRETION'
'GOBP_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS'
'GOBP_INTRACELLULAR_GLUCOSE_HOMEOSTASIS'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_PROTEIN_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_KERATINIZATION' 'GOBP_KERATINOCYTE_DEVELOPMENT'
'GOBP_KERATINOCYTE_DIFFERENTIATION' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LOCALIZATION_WITHIN_MEMBRANE' 'GOBP_LUNG_ALVEOLUS_DEVELOPMENT'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NEGATIVE_REGULATION_OF_CELL_ADHESION'
'GOBP_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PEPTIDE_TRANSPORT'
'GOBP_PHOSPHOLIPID_EFFLUX' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_PROTEIN_LOCALIZATION_TO_EXTRACELLULAR_REGION'
'GOBP_PROTEIN_LOCALIZATION_TO_PLASMA_MEMBRANE' 'GOBP_PROTEIN_TRANSPORT'
'GOBP_REGULATED_EXOCYTOSIS' 'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELL_ADHESION'
'GOBP_REGULATION_OF_CELL_CELL_ADHESION'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_EPIDERMIS_DEVELOPMENT'
'GOBP_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_HORMONE_SECRETION'
'GOBP_REGULATION_OF_INSULIN_SECRETION'
'GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_KERATINOCYTE_DIFFERENTIATION'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT'
'GOBP_REGULATION_OF_PEPTIDE_TRANSPORT'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_SECRETION'
'GOBP_REGULATION_OF_PROTEIN_TRANSPORT' 'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT' 'GOBP_RESPONSE_TO_CARBOHYDRATE'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_SECRETION'
'GOBP_SIGNAL_RELEASE' 'GOBP_SKIN_DEVELOPMENT'
'GOBP_SKIN_EPIDERMIS_DEVELOPMENT' 'GOBP_SKIN_MORPHOGENESIS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_STEROL_TRANSPORT'
'GOBP_SURFACTANT_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LAMELLAR_BODY'
'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_GRANULE_MEMBRANE'
'GOCC_SECRETORY_VESICLE' 'GOCC_TRANSPORT_VESICLE'
'GOCC_TRANSPORT_VESICLE_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING' 'GOMF_APOLIPOPROTEIN_RECEPTOR_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SIGNALING_RECEPTOR_BINDING' 'GOMF_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'MEK_UP.V1_DN' 'RAF_UP.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0034191 apolipoprotein A-I receptor binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0140326 ATPase-coupled intramembrane lipid transporter activity', 'GO:0034040 ATPase-coupled lipid transmembrane transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity', 'GO:0005102 signaling receptor binding']
|
['GO:0019725 cellular homeostasis', 'GO:0006672 ceramide metabolic process', 'GO:0035627 ceramide transport', 'GO:0033344 cholesterol efflux', 'GO:0003336 corneocyte desquamation', 'GO:0061436 establishment of skin barrier', 'GO:0006886 intracellular protein transport', 'GO:0031424 keratinization', 'GO:0055088 lipid homeostasis', 'GO:0006869 lipid transport', 'GO:0048286 lung alveolus development', 'GO:0033700 phospholipid efflux', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0032379 positive regulation of intracellular lipid transport', 'GO:2000010 positive regulation of protein localization to cell surface', 'GO:0072659 protein localization to plasma membrane', 'GO:0045055 regulated exocytosis', 'GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus', 'GO:0045616 regulation of keratinocyte differentiation', 'GO:0032940 secretion by cell', 'GO:0043129 surfactant homeostasis']
|
['GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0097209 epidermal lamellar body', 'GO:0097234 epidermal lamellar body membrane', 'GO:0000139 Golgi membrane', 'GO:0016020 membrane', 'GO:0005886 plasma membrane', 'GO:0030658 transport vesicle membrane']
|
ABCA13
|
Q86UQ4
|
ATP-binding cassette sub-family A member 13
|
May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['GOBP_AMIDE_TRANSPORT' 'GOBP_CERAMIDE_TRANSPORT' 'GOBP_ENDOCYTOSIS'
'GOBP_IMPORT_INTO_CELL' 'GOBP_LIPID_LOCALIZATION'
'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT' 'GOBP_PRESYNAPTIC_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOCYTOSIS' 'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_REGULATION_OF_SYNAPTIC_VESICLE_ENDOCYTOSIS'
'GOBP_REGULATION_OF_SYNAPTIC_VESICLE_RECYCLING'
'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT' 'GOBP_STEROL_TRANSPORT'
'GOBP_SYNAPTIC_VESICLE_RECYCLING' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT_IN_SYNAPSE' 'GOCC_AZUROPHIL_GRANULE'
'GOCC_AZUROPHIL_GRANULE_MEMBRANE' 'GOCC_SECRETORY_GRANULE'
'GOCC_SECRETORY_GRANULE_MEMBRANE' 'GOCC_SECRETORY_VESICLE'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_INNATE_IMMUNE_SYSTEM' 'REACTOME_NEUTROPHIL_DEGRANULATION']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0035627 ceramide transport', 'GO:0006869 lipid transport', 'GO:0032376 positive regulation of cholesterol transport', 'GO:1900244 positive regulation of synaptic vesicle endocytosis']
|
['GO:0035577 azurophil granule membrane', 'GO:0097708 intracellular vesicle', 'GO:0005886 plasma membrane', 'GO:0030667 secretory granule membrane']
|
ABCA2
|
Q9BZC7
|
ATP-binding cassette sub-family A member 2
|
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable) (PubMed:15238223, PubMed:21810484, PubMed:24201375). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed:22086926, PubMed:26510981). May play a role in myelin formation (By similarity)
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['CYCLIN_D1_UP.V1_UP' 'ESC_V6.5_UP_EARLY.V1_DN' 'ESC_V6.5_UP_LATE.V1_DN'
'GOBP_ALCOHOL_BIOSYNTHETIC_PROCESS' 'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMIDE_TRANSPORT'
'GOBP_AMYLOID_BETA_FORMATION' 'GOBP_AMYLOID_BETA_METABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS'
'GOBP_AXON_ENSHEATHMENT_IN_CENTRAL_NERVOUS_SYSTEM' 'GOBP_BEHAVIOR'
'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS'
'GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT'
'GOBP_CENTRAL_NERVOUS_SYSTEM_MYELIN_FORMATION'
'GOBP_CERAMIDE_METABOLIC_PROCESS' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DIOL_BIOSYNTHETIC_PROCESS'
'GOBP_DIOL_METABOLIC_PROCESS' 'GOBP_ENDOCYTOSIS'
'GOBP_ENSHEATHMENT_OF_NEURONS' 'GOBP_GANGLIOSIDE_METABOLIC_PROCESS'
'GOBP_GLIAL_CELL_DEVELOPMENT' 'GOBP_GLIAL_CELL_DIFFERENTIATION'
'GOBP_GLIOGENESIS' 'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_GLYCOSPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_GLYCOSYLATION'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_INTRACELLULAR_SPHINGOLIPID_HOMEOSTASIS'
'GOBP_INTRACELLULAR_STEROL_TRANSPORT' 'GOBP_INTRACELLULAR_TRANSPORT'
'GOBP_LIPID_BIOSYNTHETIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_LIPOSACCHARIDE_METABOLIC_PROCESS' 'GOBP_LOCOMOTORY_BEHAVIOR'
'GOBP_LOW_DENSITY_LIPOPROTEIN_RECEPTOR_PARTICLE_METABOLIC_PROCESS'
'GOBP_MACROMOLECULE_CATABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MYELIN_ASSEMBLY'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NEUROGENESIS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_OLIGODENDROCYTE_DEVELOPMENT'
'GOBP_OLIGODENDROCYTE_DIFFERENTIATION'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POLYOL_BIOSYNTHETIC_PROCESS' 'GOBP_POLYOL_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_FORMATION'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS'
'GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_PROTEIN_CATABOLIC_PROCESS'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_RECEPTOR_CATABOLIC_PROCESS' 'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_RECEPTOR_MEDIATED_ENDOCYTOSIS_INVOLVED_IN_CHOLESTEROL_TRANSPORT'
'GOBP_RECEPTOR_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ALCOHOL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CHOLESTEROL_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_CHOLESTEROL_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_INTRACELLULAR_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_INTRACELLULAR_TRANSPORT'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_GLYCOSYLATION'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS'
'GOBP_REGULATION_OF_RECEPTOR_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_HORMONE' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_STEROID_HORMONE' 'GOBP_RESPONSE_TO_STEROL'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_SPHINGOID_BIOSYNTHETIC_PROCESS' 'GOBP_SPHINGOID_METABOLIC_PROCESS'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS' 'GOBP_SPHINGOLIPID_TRANSLOCATION'
'GOBP_SPHINGOMYELIN_METABOLIC_PROCESS'
'GOBP_STEROID_BIOSYNTHETIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_BIOSYNTHETIC_PROCESS' 'GOBP_STEROL_HOMEOSTASIS'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MICROTUBULE_CYTOSKELETON' 'GOCC_MICROTUBULE_ORGANIZING_CENTER'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_TRANSPORTER_COMPLEX'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_ENDOPEPTIDASE_ACTIVITY' 'GOMF_ENDOPEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_ENZYME_REGULATOR_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_PEPTIDASE_ACTIVITY'
'GOMF_PEPTIDASE_REGULATOR_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_CHOLESTEROL_HOMEOSTASIS'
'KEGG_ABC_TRANSPORTERS' 'KEGG_LYSOSOME' 'MTOR_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0099038 ceramide floppase activity', 'GO:0061135 endopeptidase regulator activity', 'GO:0005319 lipid transporter activity', 'GO:0000166 nucleotide binding']
|
['GO:0032289 central nervous system myelin formation', 'GO:0099040 ceramide translocation', 'GO:0042632 cholesterol homeostasis', 'GO:0001573 ganglioside metabolic process', 'GO:0006687 glycosphingolipid metabolic process', 'GO:0090156 intracellular sphingolipid homeostasis', 'GO:0006629 lipid metabolic process', 'GO:0006869 lipid transport', 'GO:0007626 locomotory behavior', 'GO:0090370 negative regulation of cholesterol efflux', 'GO:0032384 negative regulation of intracellular cholesterol transport', 'GO:0071072 negative regulation of phospholipid biosynthetic process', 'GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport', 'GO:0090155 negative regulation of sphingolipid biosynthetic process', 'GO:0045939 negative regulation of steroid metabolic process', 'GO:0042986 positive regulation of amyloid precursor protein biosynthetic process', 'GO:1902993 positive regulation of amyloid precursor protein catabolic process', 'GO:1902004 positive regulation of amyloid-beta formation', 'GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process', 'GO:0032383 regulation of intracellular cholesterol transport', 'GO:1901873 regulation of post-translational protein modification', 'GO:1904375 regulation of protein localization to cell periphery', 'GO:2000008 regulation of protein localization to cell surface', 'GO:0019218 regulation of steroid metabolic process', 'GO:0070723 response to cholesterol', 'GO:0048545 response to steroid hormone', 'GO:0009410 response to xenobiotic stimulus', 'GO:0006684 sphingomyelin metabolic process', 'GO:0046512 sphingosine biosynthetic process', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0031410 cytoplasmic vesicle', 'GO:0005768 endosome', 'GO:0010008 endosome membrane', 'GO:0005765 lysosomal membrane', 'GO:0005764 lysosome', 'GO:0016020 membrane', 'GO:0005815 microtubule organizing center', 'GO:0005886 plasma membrane']
|
ABCA3
|
Q99758
|
Phospholipid-transporting ATPase ABCA3
|
Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387)
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_EXPORT_FROM_CELL' 'GOBP_GLYCEROLIPID_METABOLIC_PROCESS'
'GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INTERMEMBRANE_LIPID_TRANSFER' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_CHEMICAL_HOMEOSTASIS'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_PHOSPHATIDYLGLYCEROL_METABOLIC_PROCESS' 'GOBP_PHOSPHOLIPID_EFFLUX'
'GOBP_PHOSPHOLIPID_HOMEOSTASIS' 'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_COMPLEX_OLIGOMERIZATION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_HOMOOLIGOMERIZATION'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHOLIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY'
'GOBP_REGULATION_OF_PROTEIN_OLIGOMERIZATION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPIRATORY_SYSTEM_DEVELOPMENT' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS' 'GOBP_RESPONSE_TO_HORMONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_STEROL_TRANSPORT'
'GOBP_SURFACTANT_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_TUBE_DEVELOPMENT' 'GOBP_XENOBIOTIC_EXPORT_FROM_CELL'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_ALVEOLAR_LAMELLAR_BODY' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_LAMELLAR_BODY' 'GOCC_LATE_ENDOSOME' 'GOCC_LATE_ENDOSOME_MEMBRANE'
'GOCC_MULTIVESICULAR_BODY' 'GOCC_MULTIVESICULAR_BODY_MEMBRANE'
'GOCC_SECRETORY_GRANULE' 'GOCC_SECRETORY_GRANULE_MEMBRANE'
'GOCC_SECRETORY_VESICLE' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOCC_VESICLE_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLIPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSFER_ACTIVITY' 'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSFER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSFER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'HALLMARK_ESTROGEN_RESPONSE_EARLY'
'HALLMARK_ESTROGEN_RESPONSE_LATE' 'KEGG_ABC_TRANSPORTERS'
'KRAS.KIDNEY_UP.V1_DN' 'PID_ERA_GENOMIC_PATHWAY'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISEASES_ASSOCIATED_WITH_SURFACTANT_METABOLISM'
'REACTOME_DISEASES_OF_METABOLISM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_SURFACTANT_METABOLISM' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity', 'GO:0140345 phosphatidylcholine flippase activity', 'GO:0120019 phosphatidylcholine transfer activity']
|
['GO:0006869 lipid transport', 'GO:0030324 lung development', 'GO:0070925 organelle assembly', 'GO:0046470 phosphatidylcholine metabolic process', 'GO:0046471 phosphatidylglycerol metabolic process', 'GO:0055091 phospholipid homeostasis', 'GO:0015914 phospholipid transport', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:1902995 positive regulation of phospholipid efflux', 'GO:2001140 positive regulation of phospholipid transport', 'GO:0032464 positive regulation of protein homooligomerization', 'GO:0046890 regulation of lipid biosynthetic process', 'GO:0150172 regulation of phosphatidylcholine metabolic process', 'GO:0051384 response to glucocorticoid', 'GO:0009410 response to xenobiotic stimulus', 'GO:0043129 surfactant homeostasis', 'GO:0046618 xenobiotic export from cell', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
|
['GO:0097208 alveolar lamellar body', 'GO:0097233 alveolar lamellar body membrane', 'GO:0030659 cytoplasmic vesicle membrane', 'GO:0005615 extracellular space', 'GO:0042599 lamellar body', 'GO:0097232 lamellar body membrane', 'GO:0005770 late endosome', 'GO:0005765 lysosomal membrane', 'GO:0032585 multivesicular body membrane', 'GO:0005886 plasma membrane']
|
ABCA4
|
P78363
|
Retinal-specific phospholipid-transporting ATPase ABCA4
|
Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine is then isomerized to its all-trans isomer and reduced by RDH8 to produce all-trans-retinol. This transport activity ensures that all-trans-retinal generated from photoexcitation and 11-cis-retinal not needed for the regeneration of rhodopsin and cone opsins are effectively cleared from the photoreceptors, therefore preventing their accumulation and the formation of toxic bisretinoid (PubMed:10075733, PubMed:20404325, PubMed:22735453, PubMed:23144455, PubMed:24097981, PubMed:29847635, PubMed:33375396). Displays ATPase activity in vitro in absence of retinal substrate (PubMed:33605212, PubMed:39128720, PubMed:29847635, PubMed:33375396). May display GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds (PubMed:22735453). Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes N-retinylidene-phosphatidylethanolamine release (By similarity)
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['BMI1_DN_MEL18_DN.V1_DN' 'CRX_DN.V1_UP' 'GOBP_ALDEHYDE_METABOLIC_PROCESS'
'GOBP_DETECTION_OF_ABIOTIC_STIMULUS' 'GOBP_DETECTION_OF_LIGHT_STIMULUS'
'GOBP_DETECTION_OF_STIMULUS' 'GOBP_DETECTION_OF_VISIBLE_LIGHT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_ISOPRENOID_METABOLIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_OLEFINIC_COMPOUND_METABOLIC_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PHOTORECEPTOR_CELL_MAINTENANCE'
'GOBP_PHOTOTRANSDUCTION' 'GOBP_PHOTOTRANSDUCTION_VISIBLE_LIGHT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_LIGHT_STIMULUS'
'GOBP_RESPONSE_TO_RADIATION' 'GOBP_RETINAL_METABOLIC_PROCESS'
'GOBP_RETINA_HOMEOSTASIS' 'GOBP_SENSORY_PERCEPTION'
'GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS'
'GOBP_TERPENOID_METABOLIC_PROCESS' 'GOBP_TISSUE_HOMEOSTASIS'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_9PLUS0_NON_MOTILE_CILIUM'
'GOCC_CILIUM' 'GOCC_NEURON_PROJECTION' 'GOCC_NON_MOTILE_CILIUM'
'GOCC_PHOTORECEPTOR_DISC_MEMBRANE' 'GOCC_PHOTORECEPTOR_OUTER_SEGMENT'
'GOCC_VESICLE_MEMBRANE' 'GOMF_11_CIS_RETINAL_BINDING'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ALCOHOL_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ALL_TRANS_RETINAL_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLIPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_GTPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY' 'GOMF_ISOPRENOID_BINDING'
'GOMF_LIPID_BINDING' 'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_RETINAL_BINDING' 'GOMF_TRANSPORTER_ACTIVITY' 'GOMF_VITAMIN_BINDING'
'GOMF_VITAMIN_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'JNK_DN.V1_DN' 'KEGG_ABC_TRANSPORTERS'
'P53_DN.V1_DN' 'PKCA_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_RETINOID_CYCLE_DISEASE_EVENTS' 'REACTOME_SENSORY_PERCEPTION'
'REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'REACTOME_VISUAL_PHOTOTRANSDUCTION' 'SNF5_DN.V1_DN' 'VEGF_A_UP.V1_UP'
'WP_VISUAL_CYCLE']
|
['GO:0005502 11-cis retinal binding', 'GO:0140359 ABC-type transporter activity', 'GO:0005503 all-trans retinal binding', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0140326 ATPase-coupled intramembrane lipid transporter activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0140327 flippase activity', 'GO:0003924 GTPase activity', 'GO:0140347 N-retinylidene-phosphatidylethanolamine flippase activity', 'GO:0090555 phosphatidylethanolamine flippase activity', 'GO:0005548 phospholipid transporter activity', 'GO:0005501 retinoid binding', 'GO:0034632 retinol transmembrane transporter activity']
|
['GO:0006869 lipid transport', 'GO:0006649 phospholipid transfer to membrane', 'GO:0045332 phospholipid translocation', 'GO:0045494 photoreceptor cell maintenance', 'GO:0007603 phototransduction, visible light', 'GO:0042574 retinal metabolic process', 'GO:0001523 retinoid metabolic process', 'GO:0055085 transmembrane transport', 'GO:0007601 visual perception']
|
['GO:0031410 cytoplasmic vesicle', 'GO:0005783 endoplasmic reticulum', 'GO:0016020 membrane', 'GO:0097381 photoreceptor disc membrane', 'GO:0001750 photoreceptor outer segment', 'GO:0005886 plasma membrane', 'GO:0120202 rod photoreceptor disc membrane']
|
ABCA5
|
Q8WWZ7
|
Cholesterol transporter ABCA5
|
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity)
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['DCA_UP.V1_DN' 'GOBP_ALCOHOL_METABOLIC_PROCESS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_FOAM_CELL_DIFFERENTIATION'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_REMODELING'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MACROPHAGE_DERIVED_FOAM_CELL_DIFFERENTIATION'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_CONTAINING_COMPLEX_REMODELING'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REVERSE_CHOLESTEROL_TRANSPORT'
'GOBP_SECONDARY_ALCOHOL_METABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_HOMEOSTASIS' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LATE_ENDOSOME'
'GOCC_LATE_ENDOSOME_MEMBRANE' 'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE'
'GOCC_VESICLE_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0033344 cholesterol efflux', 'GO:0042632 cholesterol homeostasis', 'GO:0008203 cholesterol metabolic process', 'GO:0034375 high-density lipoprotein particle remodeling', 'GO:0006869 lipid transport', 'GO:0010745 negative regulation of macrophage derived foam cell differentiation', 'GO:1903064 positive regulation of reverse cholesterol transport', 'GO:0010874 regulation of cholesterol efflux', 'GO:0043691 reverse cholesterol transport']
|
['GO:0000139 Golgi membrane', 'GO:0005770 late endosome', 'GO:0031902 late endosome membrane', 'GO:0005765 lysosomal membrane', 'GO:0005764 lysosome', 'GO:0005886 plasma membrane']
|
ABCA6
|
Q8N139
|
ATP-binding cassette sub-family A member 6
|
Probable transporter which may play a role in macrophage lipid transport and homeostasis
|
['ABC transporter 1' 'ABC transporter 2']
|
[]
|
['CSR_LATE_UP.V1_DN' 'GOBP_LIPID_LOCALIZATION'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_GOLGI_APPARATUS'
'GOCC_GOLGI_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'IL21_UP.V1_UP' 'KEGG_ABC_TRANSPORTERS' 'PTEN_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_FOXO_MEDIATED_TRANSCRIPTION'
'REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES'
'REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
|
['GO:0006869 lipid transport']
|
['GO:0000139 Golgi membrane', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
ABCA7
|
Q8IZY2
|
Phospholipid-transporting ATPase ABCA7
|
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:12925201, PubMed:14570867, PubMed:14592415). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791)
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['ABC transporter 1' 'ABC transporter 2']
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['SCRIB']
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['AKT_UP.V1_UP' 'AKT_UP_MTOR_DN.V1_UP' 'ESC_V6.5_UP_EARLY.V1_DN'
'GOBP_AMIDE_METABOLIC_PROCESS' 'GOBP_AMYLOID_BETA_CLEARANCE'
'GOBP_AMYLOID_BETA_CLEARANCE_BY_CELLULAR_CATABOLIC_PROCESS'
'GOBP_AMYLOID_BETA_FORMATION' 'GOBP_AMYLOID_BETA_METABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_AMYLOID_PRECURSOR_PROTEIN_METABOLIC_PROCESS'
'GOBP_APOLIPOPROTEIN_A_I_MEDIATED_SIGNALING_PATHWAY'
'GOBP_APOPTOTIC_CELL_CLEARANCE' 'GOBP_ASSOCIATIVE_LEARNING'
'GOBP_BEHAVIOR' 'GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS'
'GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN' 'GOBP_CHOLESTEROL_EFFLUX'
'GOBP_COGNITION' 'GOBP_ENDOCYTOSIS'
'GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION'
'GOBP_ENGULFMENT_OF_APOPTOTIC_CELL' 'GOBP_ERK1_AND_ERK2_CASCADE'
'GOBP_ER_NUCLEUS_SIGNALING_PATHWAY'
'GOBP_GLYCOPROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_HIGH_DENSITY_LIPOPROTEIN_PARTICLE_ASSEMBLY' 'GOBP_IMPORT_INTO_CELL'
'GOBP_INTEGRATED_STRESS_RESPONSE_SIGNALING' 'GOBP_LEARNING'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MAPK_CASCADE' 'GOBP_MEMBRANE_INVAGINATION'
'GOBP_MEMBRANE_ORGANIZATION' 'GOBP_MEMBRANE_RAFT_ORGANIZATION'
'GOBP_MEMORY' 'GOBP_NEGATIVE_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_NEGATIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_NEGATIVE_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_NEGATIVE_REGULATION_OF_MAPK_CASCADE'
'GOBP_NEGATIVE_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_NEGATIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS'
'GOBP_NEGATIVE_REGULATION_OF_SIGNALING'
'GOBP_NEGATIVE_REGULATION_OF_TRANSPORT' 'GOBP_NERVOUS_SYSTEM_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT'
'GOBP_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE' 'GOBP_PHAGOCYTOSIS'
'GOBP_PHAGOCYTOSIS_ENGULFMENT' 'GOBP_PHOSPHOLIPID_EFFLUX'
'GOBP_PHOSPHOLIPID_TRANSLOCATION' 'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_PLASMA_MEMBRANE_ORGANIZATION'
'GOBP_PLASMA_MEMBRANE_RAFT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_AMYLOID_BETA_CLEARANCE'
'GOBP_POSITIVE_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE'
'GOBP_POSITIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE'
'GOBP_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_PHAGOCYTOSIS'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_POSITIVE_REGULATION_OF_SIGNALING'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_PROTEIN_CONTAINING_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LIPID_COMPLEX_ASSEMBLY'
'GOBP_PROTEIN_LIPID_COMPLEX_ORGANIZATION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS'
'GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE'
'GOBP_REGULATION_OF_AMIDE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_AMYLOID_BETA_CLEARANCE'
'GOBP_REGULATION_OF_AMYLOID_PRECURSOR_PROTEIN_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_APOPTOTIC_CELL_CLEARANCE'
'GOBP_REGULATION_OF_CELLULAR_LOCALIZATION'
'GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX' 'GOBP_REGULATION_OF_ENDOCYTOSIS'
'GOBP_REGULATION_OF_ENDOPLASMIC_RETICULUM_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_INVAGINATION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE'
'GOBP_REGULATION_OF_PHAGOCYTOSIS'
'GOBP_REGULATION_OF_PLASMA_LIPOPROTEIN_PARTICLE_LEVELS'
'GOBP_REGULATION_OF_PROTEIN_LOCALIZATION_TO_CELL_SURFACE'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_REGULATION_OF_RESPONSE_TO_STRESS'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS'
'GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS'
'GOBP_RESPONSE_TO_LIGHT_STIMULUS' 'GOBP_RESPONSE_TO_RADIATION'
'GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_STEROL_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_MEDIATED_TRANSPORT' 'GOBP_VISUAL_BEHAVIOR'
'GOCC_CELL_LEADING_EDGE' 'GOCC_CELL_PROJECTION_MEMBRANE'
'GOCC_CELL_SURFACE' 'GOCC_EARLY_ENDOSOME' 'GOCC_EARLY_ENDOSOME_MEMBRANE'
'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE' 'GOCC_GLIAL_CELL_PROJECTION'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LEADING_EDGE_MEMBRANE'
'GOCC_PHAGOCYTIC_CUP' 'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RUFFLE'
'GOCC_RUFFLE_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_CARGO_RECEPTOR_ACTIVITY' 'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLSERINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
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['GO:0140359 ABC-type transporter activity', 'GO:0034188 apolipoprotein A-I receptor activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0140328 floppase activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090556 phosphatidylserine floppase activity', 'GO:0005548 phospholipid transporter activity']
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['GO:0150094 amyloid-beta clearance by cellular catabolic process', 'GO:0034205 amyloid-beta formation', 'GO:0038027 apolipoprotein A-I-mediated signaling pathway', 'GO:0033344 cholesterol efflux', 'GO:0034380 high-density lipoprotein particle assembly', 'GO:0007613 memory', 'GO:0042985 negative regulation of amyloid precursor protein biosynthetic process', 'GO:1902430 negative regulation of amyloid-beta formation', 'GO:0045806 negative regulation of endocytosis', 'GO:0043409 negative regulation of MAPK cascade', 'GO:1903898 negative regulation of PERK-mediated unfolded protein response', 'GO:0006909 phagocytosis', 'GO:0033700 phospholipid efflux', 'GO:0045332 phospholipid translocation', 'GO:0044857 plasma membrane raft organization', 'GO:1900223 positive regulation of amyloid-beta clearance', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:1901076 positive regulation of engulfment of apoptotic cell', 'GO:0070374 positive regulation of ERK1 and ERK2 cascade', 'GO:0050766 positive regulation of phagocytosis', 'GO:1902995 positive regulation of phospholipid efflux', 'GO:2000010 positive regulation of protein localization to cell surface', 'GO:0034504 protein localization to nucleus', 'GO:1902991 regulation of amyloid precursor protein catabolic process', 'GO:0019216 regulation of lipid metabolic process', 'GO:0008542 visual learning']
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['GO:0030054 cell junction', 'GO:0009986 cell surface', 'GO:0031901 early endosome membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0097386 glial cell projection', 'GO:0005794 Golgi apparatus', 'GO:0000139 Golgi membrane', 'GO:0001891 phagocytic cup', 'GO:0005886 plasma membrane', 'GO:0032587 ruffle membrane']
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ABCA8
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O94911
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ABC-type organic anion transporter ABCA8
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Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799)
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['ABC transporter 1' 'ABC transporter 2']
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[]
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['ATF2_S_UP.V1_DN' 'ATF2_UP.V1_DN' 'ATM_DN.V1_UP'
'GOBP_AMIDE_BIOSYNTHETIC_PROCESS' 'GOBP_AMIDE_METABOLIC_PROCESS'
'GOBP_CHOLESTEROL_EFFLUX' 'GOBP_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_LIPID_BIOSYNTHETIC_PROCESS'
'GOBP_MEMBRANE_LIPID_METABOLIC_PROCESS'
'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS'
'GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_PHOSPHOLIPID_METABOLIC_PROCESS' 'GOBP_PHOSPHORUS_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_CHOLESTEROL_EFFLUX'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_SPHINGOLIPID_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOLIPID_METABOLIC_PROCESS'
'GOBP_SPHINGOMYELIN_BIOSYNTHETIC_PROCESS'
'GOBP_SPHINGOMYELIN_METABOLIC_PROCESS' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT' 'GOCC_BASAL_PART_OF_CELL'
'GOCC_BASOLATERAL_PLASMA_MEMBRANE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_BILE_ACID_METABOLISM' 'KEGG_ABC_TRANSPORTERS' 'PGF_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
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['GO:0140359 ABC-type transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
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['GO:0033344 cholesterol efflux', 'GO:0030301 cholesterol transport', 'GO:0006869 lipid transport', 'GO:0010875 positive regulation of cholesterol efflux', 'GO:0010874 regulation of cholesterol efflux', 'GO:0006686 sphingomyelin biosynthetic process', 'GO:0055085 transmembrane transport', 'GO:0006855 xenobiotic transmembrane transport', 'GO:0042908 xenobiotic transport']
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['GO:0016323 basolateral plasma membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0005886 plasma membrane']
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ABCA9
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Q8IUA7
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ATP-binding cassette sub-family A member 9
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Transporter that may play a role in monocyte differentiation and lipid transport and homeostasis
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['ABC transporter 1' 'ABC transporter 2']
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[]
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['GOBP_LIPID_LOCALIZATION' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_BILE_ACID_METABOLISM'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
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['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0005319 lipid transporter activity']
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['GO:0006869 lipid transport']
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['GO:0005886 plasma membrane']
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ABCB1
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P08183
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ATP-dependent translocase ABCB1
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Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
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['ABC transmembrane type-1 1' 'ABC transporter 1'
'ABC transmembrane type-1 2' 'ABC transporter 2']
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['LAPTM4B' 'RNF2']
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['BCAT.100_UP.V1_UP' 'BCAT_GDS748_UP' 'BIOCARTA_MRP_PATHWAY'
'BIOCARTA_NUCLEARRS_PATHWAY' 'BIOCARTA_P53HYPOXIA_PATHWAY'
'GOBP_AMIDE_TRANSPORT'
'GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS'
'GOBP_BODY_FLUID_SECRETION' 'GOBP_CARBOHYDRATE_DERIVATIVE_TRANSPORT'
'GOBP_CELLULAR_HYPEROSMOTIC_RESPONSE'
'GOBP_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ACID_CHEMICAL'
'GOBP_CELLULAR_RESPONSE_TO_ALKALOID'
'GOBP_CELLULAR_RESPONSE_TO_ANTIBIOTIC'
'GOBP_CELLULAR_RESPONSE_TO_BIOTIC_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_CORTICOSTEROID_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_DEXAMETHASONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_ESTRADIOL_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_GLUCOCORTICOID_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_KETONE' 'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_L_GLUTAMATE'
'GOBP_CELLULAR_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_OSMOTIC_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CELLULAR_RESPONSE_TO_SALT_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS'
'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_CELL_CYCLE'
'GOBP_CELL_CYCLE_G2_M_PHASE_TRANSITION'
'GOBP_CELL_CYCLE_PHASE_TRANSITION' 'GOBP_CELL_CYCLE_PROCESS'
'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT' 'GOBP_CERAMIDE_TRANSPORT'
'GOBP_CHLORIDE_TRANSPORT' 'GOBP_CIRCADIAN_RHYTHM'
'GOBP_CIRCULATORY_SYSTEM_PROCESS' 'GOBP_DETOXIFICATION'
'GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION'
'GOBP_DEVELOPMENT_OF_PRIMARY_SEXUAL_CHARACTERISTICS' 'GOBP_DIGESTION'
'GOBP_DIGESTIVE_SYSTEM_PROCESS' 'GOBP_EPITHELIAL_CELL_DEVELOPMENT'
'GOBP_EPITHELIAL_CELL_DIFFERENTIATION' 'GOBP_EPITHELIUM_DEVELOPMENT'
'GOBP_ESTABLISHMENT_OF_BLOOD_BRAIN_BARRIER'
'GOBP_ESTABLISHMENT_OF_BLOOD_RETINAL_BARRIER'
'GOBP_ESTABLISHMENT_OF_SERTOLI_CELL_BARRIER'
'GOBP_EXPORT_ACROSS_PLASMA_MEMBRANE' 'GOBP_EXPORT_FROM_CELL'
'GOBP_GLAND_DEVELOPMENT' 'GOBP_GLYCOSIDE_TRANSPORT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_HORMONE_TRANSPORT'
'GOBP_HYPEROSMOTIC_RESPONSE' 'GOBP_HYPEROSMOTIC_SALINITY_RESPONSE'
'GOBP_INORGANIC_ANION_TRANSPORT' 'GOBP_INTESTINAL_ABSORPTION'
'GOBP_LACTATION' 'GOBP_LIPID_LOCALIZATION'
'GOBP_MAINTENANCE_OF_BLOOD_BRAIN_BARRIER' 'GOBP_MALE_SEX_DIFFERENTIATION'
'GOBP_MAMMARY_GLAND_DEVELOPMENT' 'GOBP_MEMBRANE_ORGANIZATION'
'GOBP_MITOTIC_CELL_CYCLE' 'GOBP_MITOTIC_CELL_CYCLE_PHASE_TRANSITION'
'GOBP_MITOTIC_CELL_CYCLE_PROCESS' 'GOBP_MONOATOMIC_ANION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_NERVOUS_SYSTEM_PROCESS' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_CATION_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT' 'GOBP_PLACENTA_DEVELOPMENT'
'GOBP_POSITIVE_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_REPRODUCTIVE_PROCESS'
'GOBP_PROTEIN_LOCALIZATION_TO_BICELLULAR_TIGHT_JUNCTION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_CELL_JUNCTION'
'GOBP_PROTEIN_LOCALIZATION_TO_CELL_JUNCTION'
'GOBP_REGULATION_OF_BODY_FLUID_LEVELS'
'GOBP_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_CHLORIDE_TRANSPORT'
'GOBP_REGULATION_OF_DIGESTIVE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_HORMONE_LEVELS'
'GOBP_REGULATION_OF_INTESTINAL_ABSORPTION'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_MONOATOMIC_ANION_TRANSPORT'
'GOBP_REGULATION_OF_MONOATOMIC_ION_TRANSPORT'
'GOBP_REGULATION_OF_NERVOUS_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_REPRODUCTIVE_PROCESS'
'GOBP_REGULATION_OF_RESPONSE_TO_DRUG'
'GOBP_REGULATION_OF_SENSORY_PERCEPTION'
'GOBP_REGULATION_OF_SYSTEM_PROCESS' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_REPRODUCTIVE_PROCESS' 'GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT'
'GOBP_RESPONSE_TO_ABIOTIC_STIMULUS' 'GOBP_RESPONSE_TO_ACID_CHEMICAL'
'GOBP_RESPONSE_TO_ALCOHOL' 'GOBP_RESPONSE_TO_ALKALOID'
'GOBP_RESPONSE_TO_ANTIBIOTIC' 'GOBP_RESPONSE_TO_BACTERIUM'
'GOBP_RESPONSE_TO_CADMIUM_ION' 'GOBP_RESPONSE_TO_CORTICOSTEROID'
'GOBP_RESPONSE_TO_DEXAMETHASONE' 'GOBP_RESPONSE_TO_ENDOGENOUS_STIMULUS'
'GOBP_RESPONSE_TO_ESTRADIOL' 'GOBP_RESPONSE_TO_GLUCAGON'
'GOBP_RESPONSE_TO_GLYCOSIDE' 'GOBP_RESPONSE_TO_HORMONE'
'GOBP_RESPONSE_TO_ISOQUINOLINE_ALKALOID' 'GOBP_RESPONSE_TO_KETONE'
'GOBP_RESPONSE_TO_LIPID' 'GOBP_RESPONSE_TO_L_GLUTAMATE'
'GOBP_RESPONSE_TO_L_PHENYLALANINE_DERIVATIVE'
'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_MOLECULE_OF_BACTERIAL_ORIGIN'
'GOBP_RESPONSE_TO_MYCOTOXIN' 'GOBP_RESPONSE_TO_NITROGEN_COMPOUND'
'GOBP_RESPONSE_TO_NUTRIENT' 'GOBP_RESPONSE_TO_NUTRIENT_LEVELS'
'GOBP_RESPONSE_TO_OSMOTIC_STRESS'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_RESPONSE_TO_OXYGEN_LEVELS' 'GOBP_RESPONSE_TO_PEPTIDE'
'GOBP_RESPONSE_TO_PEPTIDE_HORMONE' 'GOBP_RESPONSE_TO_PROGESTERONE'
'GOBP_RESPONSE_TO_SALT_STRESS' 'GOBP_RESPONSE_TO_STEROID_HORMONE'
'GOBP_RESPONSE_TO_THYROID_HORMONE' 'GOBP_RESPONSE_TO_THYROXINE'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR' 'GOBP_RESPONSE_TO_VITAMIN'
'GOBP_RESPONSE_TO_VITAMIN_A' 'GOBP_RESPONSE_TO_VITAMIN_D'
'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS' 'GOBP_RHYTHMIC_PROCESS'
'GOBP_SECRETION' 'GOBP_SENSORY_PERCEPTION'
'GOBP_SENSORY_PERCEPTION_OF_PAIN' 'GOBP_SERTOLI_CELL_DEVELOPMENT'
'GOBP_SERTOLI_CELL_DIFFERENTIATION' 'GOBP_SEX_DIFFERENTIATION'
'GOBP_SPHINGOLIPID_TRANSLOCATION' 'GOBP_STEM_CELL_PROLIFERATION'
'GOBP_TISSUE_HOMEOSTASIS' 'GOBP_TRANSEPITHELIAL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM' 'GOBP_VASCULAR_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT_ACROSS_BLOOD_BRAIN_BARRIER'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_BRUSH_BORDER'
'GOCC_BRUSH_BORDER_MEMBRANE' 'GOCC_CELL_PROJECTION_MEMBRANE'
'GOCC_CELL_SURFACE' 'GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS'
'GOCC_EXTERNAL_SIDE_OF_APICAL_PLASMA_MEMBRANE'
'GOCC_EXTERNAL_SIDE_OF_PLASMA_MEMBRANE' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOCC_SIDE_OF_MEMBRANE' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY' 'GOMF_FLIPPASE_ACTIVITY'
'GOMF_FLOPPASE_ACTIVITY' 'GOMF_GLYCEROPHOSPHOLIPID_FLIPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLETHANOLAMINE_FLIPPASE_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_IL2_STAT5_SIGNALING' 'HALLMARK_KRAS_SIGNALING_UP'
'HALLMARK_PEROXISOME' 'HALLMARK_UV_RESPONSE_UP' 'KEGG_ABC_TRANSPORTERS'
'KEGG_MEDICUS_VARIANT_CDX2_OVEREXPRESSION_TO_TRANSCRIPTIONAL_ACTIVATION'
'KRAS.300_UP.V1_DN' 'KRAS.50_UP.V1_DN' 'KRAS.600_UP.V1_DN'
'KRAS.BREAST_UP.V1_DN' 'KRAS.LUNG_UP.V1_UP' 'KRAS.PROSTATE_UP.V1_DN'
'PID_HIF1_TFPATHWAY' 'REACTOME_ABACAVIR_ADME'
'REACTOME_ABACAVIR_TRANSMEMBRANE_TRANSPORT'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ATORVASTATIN_ADME' 'REACTOME_DRUG_ADME'
'REACTOME_PREDNISONE_ADME' 'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_ALLOGRAFT_REJECTION' 'WP_CODEINE_AND_MORPHINE_METABOLISM'
'WP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_IMATINIB_AND_CHRONIC_MYELOID_LEUKEMIA'
'WP_LNCRNAMEDIATED_MECHANISMS_OF_THERAPEUTIC_RESISTANCE'
'WP_MALE_INFERTILITY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY' 'WP_PREGNANE_X_RECEPTOR_PATHWAY'
'WP_PROXIMAL_TUBULE_TRANSPORT' 'WP_VITAMIN_D_RECEPTOR_PATHWAY']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0046943 carboxylic acid transmembrane transporter activity', 'GO:0099038 ceramide floppase activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0140328 floppase activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0090555 phosphatidylethanolamine flippase activity', 'GO:0140341 phosphatidylethanolamine floppase activity', 'GO:0022857 transmembrane transporter activity', 'GO:0031625 ubiquitin protein ligase binding', 'GO:0042910 xenobiotic transmembrane transporter activity']
|
['GO:1905039 carboxylic acid transmembrane transport', 'GO:0071475 cellular hyperosmotic salinity response', 'GO:0071312 cellular response to alkaloid', 'GO:0071236 cellular response to antibiotic', 'GO:1905231 cellular response to borneol', 'GO:0071549 cellular response to dexamethasone stimulus', 'GO:0071392 cellular response to estradiol stimulus', 'GO:0071217 cellular response to external biotic stimulus', 'GO:1905232 cellular response to L-glutamate', 'GO:0071222 cellular response to lipopolysaccharide', 'GO:0036146 cellular response to mycotoxin', 'GO:1904148 cellular response to nonylphenol', 'GO:0071356 cellular response to tumor necrosis factor', 'GO:0099040 ceramide translocation', 'GO:0007623 circadian rhythm', 'GO:0043215 daunorubicin transport', 'GO:0060856 establishment of blood-brain barrier', 'GO:1990963 establishment of blood-retinal barrier', 'GO:0140115 export across plasma membrane', 'GO:0007565 female pregnancy', 'GO:0000086 G2/M transition of mitotic cell cycle', 'GO:0009914 hormone transport', 'GO:0050892 intestinal absorption', 'GO:0007595 lactation', 'GO:0035633 maintenance of blood-brain barrier', 'GO:1904057 negative regulation of sensory perception of pain', 'GO:0045332 phospholipid translocation', 'GO:0001890 placenta development', 'GO:1904446 positive regulation of establishment of Sertoli cell barrier', 'GO:2001025 positive regulation of response to drug', 'GO:1902396 protein localization to bicellular tight junction', 'GO:2001225 regulation of chloride transport', 'GO:1904478 regulation of intestinal absorption', 'GO:0097305 response to alcohol', 'GO:0097327 response to antineoplastic agent', 'GO:0046686 response to cadmium ion', 'GO:1905233 response to codeine', 'GO:1905237 response to cyclosporin A', 'GO:0033762 response to glucagon', 'GO:1903416 response to glycoside', 'GO:0001666 response to hypoxia', 'GO:0032570 response to progesterone', 'GO:1905235 response to quercetin', 'GO:0097068 response to thyroxine', 'GO:0033189 response to vitamin A', 'GO:0033280 response to vitamin D', 'GO:0009410 response to xenobiotic stimulus', 'GO:0072089 stem cell proliferation', 'GO:0046865 terpenoid transport', 'GO:0070633 transepithelial transport', 'GO:0055085 transmembrane transport', 'GO:0150104 transport across blood-brain barrier', 'GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane', 'GO:0006805 xenobiotic metabolic process', 'GO:1990962 xenobiotic transport across blood-brain barrier']
|
['GO:0016324 apical plasma membrane', 'GO:0031526 brush border membrane', 'GO:0009986 cell surface', 'GO:0005737 cytoplasm', 'GO:0098591 external side of apical plasma membrane', 'GO:0070062 extracellular exosome', 'GO:0016020 membrane', 'GO:0005886 plasma membrane']
|
ABCB10
|
Q9NRK6
|
ATP-binding cassette sub-family B member 10, mitochondrial
|
ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685)
|
['ABC transmembrane type-1' 'ABC transporter']
|
['FECH']
|
['GCNP_SHH_UP_EARLY.V1_UP' 'GOBP_CELLULAR_RESPONSE_TO_STRESS'
'GOBP_CELLULAR_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_CELLULAR_RESPONSE_TO_UNFOLDED_PROTEIN'
'GOBP_ERYTHROCYTE_DEVELOPMENT' 'GOBP_ERYTHROCYTE_HOMEOSTASIS'
'GOBP_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_HEMOGLOBIN_METABOLIC_PROCESS' 'GOBP_HEMOPOIESIS'
'GOBP_HOMEOSTASIS_OF_NUMBER_OF_CELLS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS'
'GOBP_MYELOID_CELL_DEVELOPMENT' 'GOBP_MYELOID_CELL_DIFFERENTIATION'
'GOBP_MYELOID_CELL_HOMEOSTASIS' 'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION'
'GOBP_POSITIVE_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELL_DEVELOPMENT'
'GOBP_REGULATION_OF_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION'
'GOBP_REGULATION_OF_HEMOGLOBIN_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_HEMOPOIESIS'
'GOBP_REGULATION_OF_IMMUNE_SYSTEM_PROCESS'
'GOBP_REGULATION_OF_MULTICELLULAR_ORGANISMAL_DEVELOPMENT'
'GOBP_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION'
'GOBP_REGULATION_OF_PROTEIN_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'VEGF_A_UP.V1_UP']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0046872 metal ion binding', 'GO:0042803 protein homodimerization activity']
|
['GO:0048821 erythrocyte development', 'GO:0170037 export from the mitochondrion', 'GO:0006783 heme biosynthetic process', 'GO:0006839 mitochondrial transport', 'GO:0034514 mitochondrial unfolded protein response', 'GO:0045648 positive regulation of erythrocyte differentiation', 'GO:0070455 positive regulation of heme biosynthetic process', 'GO:0046985 positive regulation of hemoglobin biosynthetic process']
|
['GO:0005743 mitochondrial inner membrane', 'GO:0031966 mitochondrial membrane', 'GO:0005739 mitochondrion']
|
ABCB11
|
O95342
|
Bile salt export pump
|
Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:15791618, PubMed:16332456, PubMed:18985798, PubMed:19228692, PubMed:20010382, PubMed:20398791, PubMed:22262466, PubMed:24711118, PubMed:29507376, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269)
|
['ABC transmembrane type-1 1' 'ABC transporter 1'
'ABC transmembrane type-1 2' 'ABC transporter 2']
|
['DDIT4L']
|
['BIOCARTA_MRP_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'GOBP_ACID_SECRETION'
'GOBP_BILE_ACID_AND_BILE_SALT_TRANSPORT'
'GOBP_BILE_ACID_BIOSYNTHETIC_PROCESS' 'GOBP_BILE_ACID_METABOLIC_PROCESS'
'GOBP_BILE_ACID_SECRETION'
'GOBP_CELLULAR_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_CHEMICAL_HOMEOSTASIS' 'GOBP_EXPORT_FROM_CELL'
'GOBP_FATTY_ACID_BETA_OXIDATION' 'GOBP_FATTY_ACID_CATABOLIC_PROCESS'
'GOBP_FATTY_ACID_METABOLIC_PROCESS' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_KETONE_METABOLIC_PROCESS' 'GOBP_LIPID_CATABOLIC_PROCESS'
'GOBP_LIPID_HOMEOSTASIS' 'GOBP_LIPID_LOCALIZATION'
'GOBP_LIPID_METABOLIC_PROCESS' 'GOBP_LIPID_MODIFICATION'
'GOBP_LIPID_OXIDATION' 'GOBP_MONOCARBOXYLIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS'
'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ACID_BIOSYNTHETIC_PROCESS'
'GOBP_ORGANIC_ACID_CATABOLIC_PROCESS'
'GOBP_ORGANIC_ACID_METABOLIC_PROCESS' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_PHOSPHOLIPID_HOMEOSTASIS'
'GOBP_POSITIVE_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_SECRETION'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION'
'GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_CONJUGATION'
'GOBP_REGULATION_OF_BILE_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_BILE_ACID_SECRETION'
'GOBP_REGULATION_OF_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_BETA_OXIDATION'
'GOBP_REGULATION_OF_FATTY_ACID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_FATTY_ACID_OXIDATION'
'GOBP_REGULATION_OF_KETONE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_CATABOLIC_PROCESS'
'GOBP_REGULATION_OF_LIPID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_ORGANIC_ACID_TRANSPORT'
'GOBP_REGULATION_OF_SECRETION'
'GOBP_REGULATION_OF_SMALL_MOLECULE_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_STEROID_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TRANSPORT' 'GOBP_RESPONSE_TO_XENOBIOTIC_STIMULUS'
'GOBP_SECRETION' 'GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS'
'GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS'
'GOBP_SMALL_MOLECULE_METABOLIC_PROCESS' 'GOBP_STEROID_METABOLIC_PROCESS'
'GOBP_STEROL_HOMEOSTASIS' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_EXPORT_FROM_CELL' 'GOBP_XENOBIOTIC_METABOLIC_PROCESS'
'GOBP_XENOBIOTIC_TRANSMEMBRANE_TRANSPORT' 'GOBP_XENOBIOTIC_TRANSPORT'
'GOCC_ANCHORING_JUNCTION' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_BASAL_PART_OF_CELL' 'GOCC_BASOLATERAL_PLASMA_MEMBRANE'
'GOCC_CELL_CELL_JUNCTION' 'GOCC_CELL_SURFACE' 'GOCC_ENDOSOME'
'GOCC_ENDOSOME_MEMBRANE' 'GOCC_INTERCELLULAR_CANALICULUS'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOCC_RECYCLING_ENDOSOME'
'GOCC_RECYCLING_ENDOSOME_MEMBRANE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_BILE_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_LIPID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_MONOCARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ORGANIC_ANION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'HALLMARK_KRAS_SIGNALING_DN' 'IL21_UP.V1_UP' 'KEGG_ABC_TRANSPORTERS'
'KRAS.600_UP.V1_DN' 'KRAS.KIDNEY_UP.V1_DN'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_METABOLISM_OF_LIPIDS' 'REACTOME_METABOLISM_OF_STEROIDS'
'REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS'
'REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS'
'REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL'
'WP_BILE_ACID_SYNTHESIS_AND_ENTEROHEPATIC_CIRCULATION' 'WP_CHOLESTASIS'
'WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES'
'WP_CHOLESTEROL_METABOLISM'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY'
'WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS'
'WP_FARNESOID_X_RECEPTOR_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0015432 ABC-type bile acid transporter activity', 'GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015125 bile acid transmembrane transporter activity', 'GO:0015126 canalicular bile acid transmembrane transporter activity']
|
['GO:0015721 bile acid and bile salt transport', 'GO:0006699 bile acid biosynthetic process', 'GO:0008206 bile acid metabolic process', 'GO:0015722 canalicular bile acid transport', 'GO:0042632 cholesterol homeostasis', 'GO:0006631 fatty acid metabolic process', 'GO:0055088 lipid homeostasis', 'GO:0055091 phospholipid homeostasis', 'GO:0120189 positive regulation of bile acid secretion', 'GO:0016567 protein ubiquitination', 'GO:1904251 regulation of bile acid metabolic process', 'GO:0031998 regulation of fatty acid beta-oxidation', 'GO:0055085 transmembrane transport', 'GO:0046618 xenobiotic export from cell', 'GO:0006805 xenobiotic metabolic process', 'GO:0006855 xenobiotic transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0009986 cell surface', 'GO:0005768 endosome', 'GO:0070062 extracellular exosome', 'GO:0046581 intercellular canaliculus', 'GO:0046691 intracellular canaliculus', 'GO:0005886 plasma membrane', 'GO:0055037 recycling endosome', 'GO:0055038 recycling endosome membrane']
|
ABCB4
|
P21439
|
Phosphatidylcholine translocator ABCB4
|
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:17523162, PubMed:21820390, PubMed:23468132, PubMed:24594635, PubMed:24723470, PubMed:24806754, PubMed:31873305, PubMed:7957936, PubMed:8898203, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:28012258, PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity)
|
['ABC transmembrane type-1 1' 'ABC transporter 1'
'ABC transmembrane type-1 2' 'ABC transporter 2']
|
[]
|
['BIOCARTA_MRP_PATHWAY' 'BIOCARTA_NUCLEARRS_PATHWAY' 'CTIP_DN.V1_DN'
'GOBP_ACID_SECRETION' 'GOBP_AMIDE_TRANSPORT' 'GOBP_BILE_ACID_SECRETION'
'GOBP_CELLULAR_RESPONSE_TO_LIPID'
'GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND'
'GOBP_CERAMIDE_TRANSPORT' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_LIPID_HOMEOSTASIS'
'GOBP_LIPID_LOCALIZATION' 'GOBP_LIPID_METABOLIC_PROCESS'
'GOBP_MEMBRANE_ORGANIZATION' 'GOBP_MONOCARBOXYLIC_ACID_TRANSPORT'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_ORGANIC_ACID_TRANSPORT'
'GOBP_ORGANIC_ANION_TRANSPORT' 'GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT'
'GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT' 'GOBP_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_PHOSPHOLIPID_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_STEROL_TRANSPORT'
'GOBP_POSITIVE_REGULATION_OF_TRANSPORT'
'GOBP_REGULATION_OF_LIPID_LOCALIZATION'
'GOBP_REGULATION_OF_LIPID_TRANSPORT'
'GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION'
'GOBP_REGULATION_OF_PHOSPHOLIPID_TRANSLOCATION'
'GOBP_REGULATION_OF_STEROL_TRANSPORT' 'GOBP_REGULATION_OF_TRANSPORT'
'GOBP_RESPONSE_TO_BILE_ACID' 'GOBP_RESPONSE_TO_ETHER'
'GOBP_RESPONSE_TO_KETONE' 'GOBP_RESPONSE_TO_LIPID'
'GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND' 'GOBP_SECRETION'
'GOBP_SPHINGOLIPID_TRANSLOCATION' 'GOBP_STEROL_TRANSPORT'
'GOBP_TRANSMEMBRANE_TRANSPORT' 'GOCC_ANCHORING_JUNCTION'
'GOCC_APICAL_PART_OF_CELL' 'GOCC_CELL_CELL_JUNCTION'
'GOCC_CELL_SUBSTRATE_JUNCTION' 'GOCC_CLATHRIN_COATED_VESICLE'
'GOCC_COATED_VESICLE' 'GOCC_INTERCELLULAR_CANALICULUS'
'GOCC_MEMBRANE_MICRODOMAIN' 'GOCC_PLASMA_MEMBRANE_REGION'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_FLOPPASE_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_INTRAMEMBRANE_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_LIPID_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_FLOPPASE_ACTIVITY'
'GOMF_PHOSPHATIDYLCHOLINE_TRANSPORTER_ACTIVITY'
'GOMF_PHOSPHOLIPID_TRANSPORTER_ACTIVITY'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_SPHINGOLIPID_TRANSPORTER_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_PEROXISOME' 'JAK2_DN.V1_UP' 'KEGG_ABC_TRANSPORTERS'
'NRL_DN.V1_DN' 'PRC1_BMI_UP.V1_UP'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_METABOLISM_OF_LIPIDS'
'REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES' 'WP_CHOLESTASIS'
'WP_DISORDERS_OF_BILE_ACID_SYNTHESIS_AND_BILIARY_TRANSPORT'
'WP_FARNESOID_X_RECEPTOR_PATHWAY'
'WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY'
'WP_NUCLEAR_RECEPTORS_METAPATHWAY']
|
['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0090554 phosphatidylcholine floppase activity', 'GO:0005548 phospholipid transporter activity']
|
['GO:0032782 bile acid secretion', 'GO:1903413 cellular response to bile acid', 'GO:0055088 lipid homeostasis', 'GO:0006629 lipid metabolic process', 'GO:0045332 phospholipid translocation', 'GO:0032376 positive regulation of cholesterol transport', 'GO:0061092 positive regulation of phospholipid translocation', 'GO:2001140 positive regulation of phospholipid transport', 'GO:1901557 response to fenofibrate', 'GO:0055085 transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0030136 clathrin-coated vesicle', 'GO:0005737 cytoplasm', 'GO:0005829 cytosol', 'GO:0070062 extracellular exosome', 'GO:0005925 focal adhesion', 'GO:0046581 intercellular canaliculus', 'GO:0016020 membrane', 'GO:0045121 membrane raft', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane']
|
ABCB5
|
Q2M3G0
|
ATP-binding cassette sub-family B member 5
|
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity)
|
['ABC transmembrane type-1 1' 'ABC transporter 1'
'ABC transmembrane type-1 2' 'ABC transporter 2']
|
[]
|
['GOBP_REGULATION_OF_MEMBRANE_POTENTIAL' 'GOBP_SENSORY_ORGAN_DEVELOPMENT'
'GOBP_SENSORY_SYSTEM_DEVELOPMENT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_XENOBIOTIC_TRANSPORT' 'GOCC_APICAL_PART_OF_CELL'
'GOCC_PLASMA_MEMBRANE_REGION' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ABC_TYPE_XENOBIOTIC_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY'
'GOMF_XENOBIOTIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'KEGG_ABC_TRANSPORTERS' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0008559 ABC-type xenobiotic transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015562 efflux transmembrane transporter activity']
|
['GO:0030154 cell differentiation', 'GO:0001654 eye development', 'GO:0042391 regulation of membrane potential', 'GO:0055085 transmembrane transport']
|
['GO:0016324 apical plasma membrane', 'GO:0005886 plasma membrane']
|
ABCB6
|
Q9NP58
|
ATP-binding cassette sub-family B member 6
|
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:17661442, PubMed:23792964, PubMed:27507172, PubMed:33007128). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:10837493, PubMed:17006453, PubMed:23792964, PubMed:33007128). May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (PubMed:29940187). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (PubMed:21266531, PubMed:25202056, PubMed:31053883). In addition may play a role in the transition metal homeostasis (By similarity)
|
['ABC transmembrane type-1' 'ABC transporter']
|
[]
|
['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CELLULAR_PIGMENTATION'
'GOBP_CELLULAR_RESPONSE_TO_CADMIUM_ION'
'GOBP_CELLULAR_RESPONSE_TO_METAL_ION'
'GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE'
'GOBP_CENTRAL_NERVOUS_SYSTEM_DEVELOPMENT' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_COPPER_ION_HOMEOSTASIS' 'GOBP_DETOXIFICATION'
'GOBP_DETOXIFICATION_OF_CADMIUM_ION'
'GOBP_DETOXIFICATION_OF_INORGANIC_COMPOUND' 'GOBP_HEAD_DEVELOPMENT'
'GOBP_HEME_B_METABOLIC_PROCESS' 'GOBP_HEME_TRANSPORT'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_INORGANIC_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_COPPER_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_IRON_COORDINATION_ENTITY_TRANSPORT'
'GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT' 'GOBP_IRON_ION_TRANSPORT'
'GOBP_MELANOSOME_ASSEMBLY' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT' 'GOBP_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_NITROGEN_COMPOUND_TRANSPORT'
'GOBP_ORGANELLE_ASSEMBLY' 'GOBP_PIGMENTATION'
'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS' 'GOBP_PIGMENT_GRANULE_ORGANIZATION'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_RESPONSE_TO_CADMIUM_ION' 'GOBP_RESPONSE_TO_METAL_ION'
'GOBP_RESPONSE_TO_TOXIC_SUBSTANCE' 'GOBP_SKIN_DEVELOPMENT'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TRANSITION_METAL_ION_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOBP_VESICLE_ORGANIZATION'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX' 'GOCC_CHITOSOME'
'GOCC_EARLY_ENDOSOME' 'GOCC_EARLY_ENDOSOME_MEMBRANE' 'GOCC_ENDOLYSOSOME'
'GOCC_ENDOLYSOSOME_MEMBRANE' 'GOCC_ENDOSOME' 'GOCC_ENDOSOME_MEMBRANE'
'GOCC_GOLGI_APPARATUS' 'GOCC_GOLGI_MEMBRANE' 'GOCC_LATE_ENDOSOME'
'GOCC_LATE_ENDOSOME_MEMBRANE' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_MULTIVESICULAR_BODY' 'GOCC_MULTIVESICULAR_BODY_MEMBRANE'
'GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_SUBCOMPARTMENT'
'GOCC_OUTER_MEMBRANE' 'GOCC_PIGMENT_GRANULE'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_TRANSPORTER_COMPLEX'
'GOCC_VACUOLAR_MEMBRANE' 'GOCC_VACUOLE' 'GOCC_VESICLE_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_EFFLUX_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TETRAPYRROLE_BINDING' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_GLYCOLYSIS' 'HALLMARK_HEME_METABOLISM' 'KEGG_ABC_TRANSPORTERS'
'NFE2L2.V2' 'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_ABC_TRANSPORTER_DISORDERS'
'REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
|
['GO:0015439 ABC-type heme transporter activity', 'GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0015562 efflux transmembrane transporter activity', 'GO:0020037 heme binding', 'GO:0046906 tetrapyrrole binding']
|
['GO:0007420 brain development', 'GO:0098849 cellular detoxification of cadmium ion', 'GO:0042168 heme metabolic process', 'GO:0035351 heme transmembrane transport', 'GO:0015886 heme transport', 'GO:0006878 intracellular copper ion homeostasis', 'GO:0006879 intracellular iron ion homeostasis', 'GO:1903232 melanosome assembly', 'GO:0006779 porphyrin-containing compound biosynthetic process', 'GO:0006778 porphyrin-containing compound metabolic process', 'GO:0043588 skin development', 'GO:0033013 tetrapyrrole metabolic process', 'GO:0055085 transmembrane transport']
|
['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0005829 cytosol', 'GO:0031901 early endosome membrane', 'GO:0036020 endolysosome membrane', 'GO:0005783 endoplasmic reticulum', 'GO:0005789 endoplasmic reticulum membrane', 'GO:0005768 endosome', 'GO:0070062 extracellular exosome', 'GO:0005794 Golgi apparatus', 'GO:0000139 Golgi membrane', 'GO:0005765 lysosomal membrane', 'GO:0033162 melanosome membrane', 'GO:0005740 mitochondrial envelope', 'GO:0005741 mitochondrial outer membrane', 'GO:0005739 mitochondrion', 'GO:0032585 multivesicular body membrane', 'GO:0005654 nucleoplasm', 'GO:0005886 plasma membrane', 'GO:0097225 sperm midpiece', 'GO:0097228 sperm principal piece', 'GO:0005774 vacuolar membrane']
|
ABCB7
|
O75027
|
Iron-sulfur clusters transporter ABCB7, mitochondrial
|
Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:10196363, PubMed:17192393, PubMed:33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity)
|
['ABC transmembrane type-1' 'ABC transporter']
|
['ABCB7' 'FECH']
|
['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CHEMICAL_HOMEOSTASIS'
'GOBP_HEME_TRANSPORT' 'GOBP_HOMEOSTATIC_PROCESS'
'GOBP_INORGANIC_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_IRON_ION_HOMEOSTASIS'
'GOBP_INTRACELLULAR_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_IRON_COORDINATION_ENTITY_TRANSPORT'
'GOBP_IRON_ION_TRANSMEMBRANE_TRANSPORT' 'GOBP_IRON_ION_TRANSPORT'
'GOBP_METALLO_SULFUR_CLUSTER_ASSEMBLY' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT' 'GOBP_MONOATOMIC_ION_HOMEOSTASIS'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_NITROGEN_COMPOUND_TRANSPORT' 'GOBP_PIGMENT_BIOSYNTHETIC_PROCESS'
'GOBP_PIGMENT_METABOLIC_PROCESS'
'GOBP_PORPHYRIN_CONTAINING_COMPOUND_METABOLIC_PROCESS'
'GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION'
'GOBP_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS'
'GOBP_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS'
'GOBP_REGULATION_OF_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TETRAPYRROLE_BIOSYNTHETIC_PROCESS'
'GOBP_TETRAPYRROLE_METABOLIC_PROCESS'
'GOBP_TRANSITION_METAL_ION_TRANSPORT' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HEME_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_PROTEIN_DIMERIZATION_ACTIVITY'
'GOMF_PROTEIN_HOMODIMERIZATION_ACTIVITY' 'GOMF_TRANSPORTER_ACTIVITY'
'HALLMARK_OXIDATIVE_PHOSPHORYLATION' 'KEGG_ABC_TRANSPORTERS'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_CYTOSOLIC_IRON_SULFUR_CLUSTER_ASSEMBLY'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES'
'WP_IRONSULFUR_CLUSTER_BIOGENESIS']
|
['GO:0140481 ABC-type iron-sulfur cluster transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity', 'GO:0015232 heme transmembrane transporter activity', 'GO:0042802 identical protein binding', 'GO:0042803 protein homodimerization activity']
|
['GO:0006879 intracellular iron ion homeostasis', 'GO:0034755 iron ion transmembrane transport', 'GO:0016226 iron-sulfur cluster assembly', 'GO:0140466 iron-sulfur cluster export from the mitochondrion', 'GO:1903427 negative regulation of reactive oxygen species biosynthetic process', 'GO:0070455 positive regulation of heme biosynthetic process', 'GO:1903331 positive regulation of iron-sulfur cluster assembly', 'GO:0055085 transmembrane transport']
|
['GO:0005743 mitochondrial inner membrane', 'GO:0005739 mitochondrion']
|
ABCB8
|
Q9NUT2
|
Mitochondrial potassium channel ATP-binding subunit
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ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane (PubMed:31435016). An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix (PubMed:31435016). Plays a role in mitochondrial iron transport (PubMed:30623799). Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)
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['ABC transmembrane type-1' 'ABC transporter']
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['CCDC51']
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['GOBP_CELLULAR_HOMEOSTASIS' 'GOBP_CELL_VOLUME_HOMEOSTASIS'
'GOBP_HOMEOSTATIC_PROCESS' 'GOBP_METAL_ION_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSMEMBRANE_TRANSPORT'
'GOBP_MITOCHONDRIAL_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_CATION_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSMEMBRANE_TRANSPORT'
'GOBP_MONOATOMIC_ION_TRANSPORT' 'GOBP_POTASSIUM_ION_TRANSPORT'
'GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE'
'GOBP_REGULATION_OF_CELLULAR_COMPONENT_SIZE'
'GOBP_REGULATION_OF_CELL_SIZE' 'GOBP_TRANSMEMBRANE_TRANSPORT'
'GOCC_ATPASE_DEPENDENT_TRANSMEMBRANE_TRANSPORT_COMPLEX'
'GOCC_ATP_BINDING_CASSETTE_ABC_TRANSPORTER_COMPLEX'
'GOCC_CATION_CHANNEL_COMPLEX' 'GOCC_MEMBRANE_PROTEIN_COMPLEX'
'GOCC_MITOCHONDRIAL_ENVELOPE' 'GOCC_MITOCHONDRION'
'GOCC_MONOATOMIC_ION_CHANNEL_COMPLEX' 'GOCC_NUCLEOLUS'
'GOCC_ORGANELLE_ENVELOPE' 'GOCC_ORGANELLE_INNER_MEMBRANE'
'GOCC_PLASMA_MEMBRANE_PROTEIN_COMPLEX' 'GOCC_POTASSIUM_CHANNEL_COMPLEX'
'GOCC_TRANSPORTER_COMPLEX' 'GOMF_ABC_TYPE_TRANSPORTER_ACTIVITY'
'GOMF_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ADENYL_NUCLEOTIDE_BINDING'
'GOMF_ATPASE_COUPLED_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_ATP_DEPENDENT_ACTIVITY' 'GOMF_ATP_HYDROLYSIS_ACTIVITY'
'GOMF_HYDROLASE_ACTIVITY_ACTING_ON_ACID_ANHYDRIDES'
'GOMF_PRIMARY_ACTIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY'
'GOMF_TRANSPORTER_ACTIVITY' 'HALLMARK_ADIPOGENESIS'
'KEGG_ABC_TRANSPORTERS' 'KRAS.AMP.LUNG_UP.V1_DN' 'PRC2_EED_DN.V1_DN'
'REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT'
'REACTOME_TRANSPORT_OF_SMALL_MOLECULES']
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['GO:0140359 ABC-type transporter activity', 'GO:0005524 ATP binding', 'GO:0016887 ATP hydrolysis activity', 'GO:0042626 ATPase-coupled transmembrane transporter activity']
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['GO:0006884 cell volume homeostasis', 'GO:0140141 mitochondrial potassium ion transmembrane transport', 'GO:0071805 potassium ion transmembrane transport', 'GO:0055085 transmembrane transport']
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['GO:0043190 ATP-binding cassette (ABC) transporter complex', 'GO:0016020 membrane', 'GO:0062157 mitochondrial ATP-gated potassium channel complex', 'GO:0005743 mitochondrial inner membrane', 'GO:0031966 mitochondrial membrane', 'GO:0005739 mitochondrion', 'GO:0005730 nucleolus', 'GO:0005654 nucleoplasm']
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